Results 71 to 80 of about 15,844 (217)

Amyloid β alters vascular CaV1.2 channel spatiotemporal properties

The Journal of Physiology, EarlyView.
Abstract figure legend Amyloid‐β1‐42 (Aβ1‐42) triggers a male‐specific signalling cascade influencing CaV1.2 spatiotemporal properties in cerebral vascular smooth muscle. The signalling pathway involves NADPH oxidase (NOX)‐derived reactive oxygen species (ROS) activation of protein kinase C (PKC). Aβ1‐42 can also activate protein kinase A (PKA).
Jade L. Taylor, Miguel Martin‐Aragon Baudel, Eric Pereira da Silva, Johannes W. Hell, Madeline Nieves‐Cintron, Manuel F. Navedo   +5 more
wiley   +1 more source

Glyoxal induces DNA-Protein Crosslinking in Cells

Glyoxal (GO) is a small, highly reactive molecule that is produced naturally in cells during normal metabolism and can also come from processed foods and oxidative stress.
Luke Erber, Elijah M Barnes, Krishna C Gurajala   +2 more
core   +1 more source

Intracellular mechanosensation in intestinal smooth muscle: Piezo1 complexes amplify signalling beyond the surface

The Journal of Physiology, EarlyView.
Abstract figure legend Mechanosensation is not confined to the cell surface. In intestinal smooth muscle Piezo1 is predominantly intracellular (86%), where it forms a nanoscale (<40 nm) complex at the sarcoplasmic reticulum (SR)–plasma membrane junction. Within this sensor–amplifier–effector axis intra‐Piezo1 is the sensor that detects force at the SR,
Geoanna M. Bautista, Declan Manning, Emily C. Lieu, Stephanie I. Ugochukwu, Collin Matsumoto, Joshua P. Tulman, Miguel Martin‐Aragon Baudel, Nuria Daghbouche‐Rubio, Steven J. McElroy, Sal A. Baker, Manuel F. Navedo, L. Fernando Santana   +11 more
wiley   +1 more source

Mucosal‐Associated Invariant T Cells in Health and Disease

MedComm, Volume 7, Issue 10, October 2026.
The roles of MAIT cells in health and disease and their therapeutic applications. In healthy individuals, riboflavin metabolites secreted by commensal bacteria at mucosal sites are presented by MR1, leading to the activation of MAIT cells. Activated MAIT cells can maintain the barrier integrity of mucosal tissues in a steady state or migrate to the ...
Yu Zhao, Feng‐Mi Ou, Dan Liang, Yang Gao, Qing‐Qing Li, Yi‐Qun Kuang   +5 more
wiley   +1 more source

Unspecific Peroxygenase‐Based Chemo‐Enzymatic Synthesis of Amino Alcohols for Pharmaceutical Preparation

ChemBioChem, Volume 27, Issue 18, 28 September 2026.
The conversion of amines using nonspecific peroxygenases has always presented a challenge. The use of specific protecting groups, combined with the integration of enzymatic catalysis into conventional chemical methods, opens up new possibilities for the direct and enantioselective synthesis of valuable pharmaceuticals in an innovative, cost‐effective ...
Simon Last, Alina Gazizova, Katharina Wittmann, Niklas Dietz, Martin J. Weissenborn, Jan von Langermann   +5 more
wiley   +1 more source

Significant Aqueous‐Phase Processing of Secondary Aerosols Associated With South Asian Outflow in the Water Vapor Channel of the Southeastern Tibetan Plateau

Geophysical Research Letters, Volume 53, Issue 17, 16 September 2026.
Abstract Ambient aerosols exert growing influences on atmospheric radiative forcing, precipitation, and climate change over the Tibetan Plateau (TP), yet observational constraints on their chemical characteristics remain sparse in this high‐altitude region.
Xinghua Zhang, Jianzhong Xu, Yanqing An, Lixiang Zhai, Miao Zhong, Tong Ren, Siyu Jiang, Bingke Li   +7 more
wiley   +1 more source

From Traditional Spice to Functional Ingredient: Phenolic Profile and Bioactive Properties of Sicilian Rhus coriaria L. Fruit

Chemistry &Biodiversity, Volume 23, Issue 9, September 2026.
The phenolic composition of Rhus coriaria fruits has been comprehensively characterized and linked to a variety of biological activities, including antioxidant, anti‐glycation, enzyme‐inhibitory, and cytoprotective effects. These findings highlight the functional potential of Sicilian sumac as a valuable source of health‐promoting phytochemicals ...
Katia Arena, Donatella Ambroselli, Roberto Laganà Vinci, Luigi Mondello, Luca Santi, Laura Dugo, Paola Dugo   +6 more
wiley   +1 more source

Hydrazone‐Type Ligands for Asymmetric Catalysis

ChemistryEurope, Volume 4, Issue 9, September 2026.
The introduction of trans 2,5‐disubstituted pyrrolidines is the key design element enabling the excellent stereocontrol exerted by hydrazone‐based N‐ligands in a variety of transition metal‐catalyzed transformations, including Diels–Alder cycloadditions, Suzuki/Hiyama/Negishi cross‐couplings, 1,2‐additions to a variety of imines and hydrazones, and ...
Esteban Matador, Saúl Alberca, Rosario Fernández, David Monge, José M. Lassaletta   +4 more
wiley   +1 more source

Wnt Glycation Inhibits Canonical Signaling

Cells, 2019
Glycation occurs as a non-enzymatic reaction between amino and thiol groups of proteins, lipids, and nucleotides with reducing sugars or α-dicarbonyl metabolites.
Zhennan Ye, Sonnhild Mittag, Martin Schmidt, Andreas Simm, Rüdiger Horstkorte, Otmar Huber   +5 more
doaj   +1 more source

Efficient One‐Pot Synthesis of 1,2,4,5‐Tetrasubstituted Imidazoles Using GO@SiO2@[(CH2)3Im][Cl] as a Novel Nanocomposite Under MW Irradiation

ChemistryOpen, Volume 15, Issue 9, September 2026.
This study presents the development of a novel nanocomposite catalyst, GO@SiO2@[(CH2)3Im][Cl], for the efficient one‐pot synthesis of 1,2,4,5‐tetrasubstituted imidazoles under environmentally benign conditions. The catalyst design incorporates graphene oxide, silica, and an imidazolium‐functionalized layer, creating a unique catalytic environment for ...
Mohamed Abu Shuheil, Afaq Mahdi Ali, Mekkanti Manasa Rekha, Subhashree Ray, Talal Aziz Qassem, T. Krithiga, Renu Sharma, Prakhar Tomar, Reza Mohammadi   +8 more
wiley   +1 more source