Results 191 to 200 of about 195,338 (284)

Oncolytic HSV-1 expressing GM-CSF and IL-12 enhances anti-tumor efficacy in immunocompetent murine melanoma model. [PDF]

Virol Sin
Xiao H, Yin Q, Liu J, Hu H, Li J, Wang M, Hu Z.   +6 more
europepmc   +1 more source

Assessing transporter‐mediated rifampin–linezolid interaction using physiologically‐based pharmacokinetic modelling

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aims The study aims to develop a physiologically‐based pharmacokinetic (PBPK) model to quantitatively evaluate the role of ATP‐binding cassette sub‐family B member 1 (ABCB1) and ATP‐binding cassette super‐family G member 2 (ABCG2) in the drug–drug interaction (DDI) between rifampin and linezolid and to predict the impact of high‐dose rifampin ...
Hoang Dat Nguyen, Vinh Hoa Pham, Richard M. Hoglund, Joel Tarning, Junjie Ding   +4 more
wiley   +1 more source

IL-12 and GM-CSF engineered dendritic cells enhance the enrichment and selection of tumor-reactive T cells for cancer immunotherapy. [PDF]

Front Immunol
Liu Z, Li H, Gao Z, Cheng R, Lu J, Che X, Dong J, Wang Z, Cui Z, Gu J, Bai Y, Li C, Liu Y, Wang C, Deng H.   +14 more
europepmc   +1 more source

A Michaelis‐Arbuzov‐Type Pathway to a Protected 2ʹ‐Deoxy‐2ʹ‐Selenomethyl‐Adenosine‐3ʹ,5ʹ‐Phosphoroselenolate Guanosine Dinucleotide for Use in Modified m7G Cap Synthesis

Chemistry – A European Journal, EarlyView.
Here we report a synthesis of the dinucleotide 4 for a projected future total synthesis of the m7G cap 1. Highlights of the route include: 1) a 3ʹ‐H‐phosphonate/5ʹ‐selenocyanate Michaelis‐Arbuzov coupling to forge the 3ʹ,5ʹ‐phosphoroselenolate; 2) an Amosova reductive selenomethylation to install the 2ʹ‐SeMe; 3) a solid CPR II 5ʹ‐O‐phosphitylation; and
K. Lawrence E. Hale, Helen O. McCarthy, Mark G. McLaughlin   +2 more
wiley   +1 more source

GM-CSF potentiates macrophages to retain an inflammatory feature from their circulating monocyte precursors in rheumatoid arthritis. [PDF]

J Transl Med
Chen J, Zhan M, Zhao Y, Xu H, Feng F, Bai Z, Zhang K, Fu L, Wang F, Cheng Y, Zhang X, Liu Y.   +11 more
europepmc   +1 more source

Inhaled GM-CSF for Pulmonary Alveolar Proteinosis

New England Journal of Medicine, 2020
Papiris, S.A., Griese, M., Manali, E.D.
openaire   +3 more sources

One‐Pot Transition‐Metal‐Free Methods for the Synthesis of All Three Bonds of the Alkyne's Triple Bond

Chemistry – A European Journal, EarlyView.
One‐pot transition‐metal‐free methods for the synthesis of all three bonds of the alkyne's triple bond are reviewed. After analysis of several named reactions and discussion of improvements, recent advances in the synthesis of alkynes are discussed. Each section contains a proposed reaction mechanism and analysis of the strengths and weaknesses of the ...
Eugene Kim, Yu Wu, Judith N. Currano, Jianyou Mao, Patrick J. Walsh   +4 more
wiley   +1 more source

Early‐Life Clinical Factors Shape Cerebellar Structure in Preterm‐Born Children

Annals of the Child Neurology Society, EarlyView.
ABSTRACT Objective Preterm birth alters typical brain development due to complex exposures related to neonatal illness, pain management, and brain injury. Despite an increased understanding of neonatal brain injury on developmental outcomes, the association of cerebellar maturation with school‐age motor and cognitive function remains incompletely ...
Victoria Rapos, Steven Ufkes, Cecil Chau, Jessie van Dyk, Ting Guo, Ruth E. Grunau, Steven P. Miller   +6 more
wiley   +1 more source

Reprogramming of GM-CSF-dependent alveolar macrophages through GSK3 activity modulation. [PDF]

Elife
Ríos I, Herrero C, Torres-Torresano M, López-Navarro B, Schiaffino MT, Díaz Crespo F, Nieto-Valle A, Samaniego R, Sierra-Palomares Y, Oliver E, Revuelta-Salgado F, García-Luján R, Sánchez-Mateos P, Delgado R, Puig-Kröger A, Corbí AL.   +15 more
europepmc   +1 more source

RORγt‐APCs: The New Masters of Oral Tolerance

Barrier Immunity, EarlyView.
ABSTRACT Oral tolerance is defined by the hypo‐responsiveness of our body to fed antigens, and its failure can lead to immune‐mediated diseases, such as allergy, chronic inflammation and autoimmune diseases. Decades of research have demonstrated that antigen‐presenting cells (APCs) promote oral tolerance by inducing regulatory T cells (Tregs) and/or ...
Thierry Gauthier, WanJun Chen
wiley   +1 more source