Results 211 to 220 of about 332,782 (345)

First‐in‐human, phase I, randomized, safety, pharmacokinetic, food‐effect and pharmacodynamic study of a tyrosine kinase 2/Janus kinase 1 inhibitor, SDC‐1801

British Journal of Clinical Pharmacology, EarlyView.
Aim The purpose of this study is to evaluate safety, tolerability, pharmacokinetics (PK), food‐effect (FE) and pharmacodynamics (PD) of an oral tyrosine kinase‐2 (TYK2)/Janus kinase‐1 (JAK1) inhibitor, SDC‐1801, in healthy adult participants. Methods This first‐in‐human study randomized 95 male and female participants.
Chris Brearley, Sam Francis, John Reader, Judi Proctor   +3 more
wiley   +1 more source

GM-CSF and IL-1α secreted by cryopreserved porcine skin promote angiogenesis in burn wounds by activating the JAK2/STAT3 pathway. [PDF]

Am J Transl Res
Liu Y, Zuo H, Shao Y, Gao C, Liu X, Song G.   +5 more
europepmc   +1 more source

Severe Adverse Immunologic Reaction in a Patient with Glioblastoma Receiving Autologous Dendritic Cell Vaccines Combined with GM-CSF and Dose-Intensified Temozolomide [PDF]

, 2014
Duane A. Mitchell, Elias Sayour, Elizabeth A. Reap, Robert J. Schmittling, Gabriel DeLeon, Pamela K. Norberg, Annick Desjardins, Allan H. Friedman, Henry S. Friedman, Gary E. Archer, John H. Sampson   +10 more
openalex   +1 more source

A nanoplatform that induces dual‐amino acid deprivation to reverse tumor immunosuppression and enhance metabolic immunotherapy

BMEMat, EarlyView.
ZIF‐8‐based nanoparticles co‐delivering CB‐839 (glutaminase inhibitor) and 1‐MT (IDO1 inhibitor), dual‐targeting glutamine/tryptophan metabolism to induce immunogenic cell death, activate STING, block kynurenine production, reverse immunosuppression, and enhance cancer immunotherapy to suppress primary/distant tumors.
Wenli Ning, Yunhan Sun, Mingyang Li, Shilu Liu, Fangjie Yi, Hongfei Wang, Ruibing Bai, Dongdong Liu, Fen Zhao, Guiqiang Zhang, Xiao Fu   +10 more
wiley   +1 more source

Neurovascular coupling in bone regeneration: Mechanisms, advanced biomaterials and challenges

BMEMat, EarlyView.
This figure illustrates various material strategies for neurovascularized bone regeneration, including electroactive scaffolds, ion‐loaded materials, drug delivery systems, surface modifications, cells/cell products, growth factors, and peptides. These approaches aim to synergistically promote the regeneration of neural, vascular, and bone tissues ...
Yixin Ma, Nan Jiang, Liyuan Chen, He Zhang, Xinjia Cai, Karan Gulati, Danqing He, Zhigang Cai, Yan Liu   +8 more
wiley   +1 more source

<i>Mycobacterium tuberculosis</i> Impairs Human Memory CD4 T Cell Recognition of Macrophages Differentiated Using M-CSF But Not GM-CSF

, 2023
Daniel P. Gail, Vinicius G. Suzart, Weinan Du, Avinaash K. Sandhu, Jessica Jarvela, Mary Nantongo, Ivan Mwebaza, Soumya Panigrahi, Michael L. Freeman, David H. Canaday, W. Henry Boom, Richard F. Silver, Stephen M. Carpenter   +12 more
openalex   +1 more source

GM-CSF⁺ Th: a central player in autoimmunity. [PDF]

Theranostics
Fan SS, Xu X, Luo YB, Meng XY, Liu Y.
europepmc   +1 more source

The Role of Glycan Structures in Modulating GM-CSF Bioactivity: Insights from Glycoengineering

Ece Çağdaş, Sarah Line Skovbakke, Judit Pina Agullet, Leo Alexander Dworkin, Giulia Scapin, Hooman Hefzi, Karoline Schousboe Fremming, Sanne Schoffhelen, Natalia Putkaradze, Björn G. Voldborg, Lise Marie Grav, Nielsen Lk, Steffen Goletz, Nathan E. Lewis   +13 more
openalex   +1 more source

Dual‐targeted nanomedicine delivering doxorubicin and nitric oxide for tumor immunomodulation and synergistic therapy

BMEMat, EarlyView.
The mechanism of HA‐DS@PLGA nanoparticles co‐delivering DOX and SNAP (an NO donor) to suppress tumor growth, remodel the tumor microenvironment, and enhance antitumor immune responses for effective combinatorial cancer therapy. Abstract Cancer therapeutic efficacy is significantly influenced by tumor immunosuppressive environment possibly induced by ...
Xingzhou Peng, Wei Chen, Shuyu Li, Xiaomin Ma, Yanfeng Dai, Yan Wang, Changqiang Xie, Yazhe Xiao, Hesong Han, Yumiao Zhang, Junjie Wang   +10 more
wiley   +1 more source

Oncolytic Virus VV-GMCSF-Lact and Human GM-CSF Against GL261 Glioma in Immunocompetent Mice. [PDF]

Pharmaceuticals (Basel)
Ageenko AB, Vasileva NS, Chesnokova AS, Semenov DV, Byvakina AA, Dymova MA, Sen'kova AV, Nushtaeva AA, Leonteva AA, Savinovskaya YI, Kochneva GV, Richter VA, Kuligina EV.   +12 more
europepmc   +1 more source