Results 211 to 220 of about 192,172 (285)

Impaired granulocyte-macrophage colony-stimulating factor bioactivity accelerates surgical recurrence in ileal Crohn’s disease [PDF]

, 2018
Bonkowski, Erin, Chalk, Claudia, Denson, Lee, Gathungu, Grace, Krumsiek, Julia, Li, Ellen, Newberry, Rodney, Nix, Billy, Rowehl, Leahana, Tian, Xinyu, Trapnell, Bruce, Zhang, Yuanhao, Zhu, Wei   +12 more
core   +2 more sources

Glymphatic dysfunction couples with cortical excitation–inhibition imbalance in epilepsy: Evidence from Rasmussen encephalitis

Epilepsia, EarlyView.
Cong Fu et al. demonstrate that glymphatic system dysfunction is linked to enhanced inhibitory cortical activity using diffusion MRI and EEG. These findings highlight a mechanistic link between perivascular fluid dynamics and neuronal activity, suggesting a role for glymphatic function in maintaining cortical stability in epilepsy.
Cong Fu, Yujiao Yang, Pan Gong, Kun Lv, Yilin Liu, Chongyang Tang, Xiongfei Wang, Lixin Cai, Qingzhu Liu, Yuwu Jiang, Taoyun Ji, Guoming Luan   +11 more
wiley   +1 more source

Pharmacokinetics, Safety and Tolerability of Intravenous Lenzilumab, an Anti-GM-CSF Monoclonal Antibody Drug, in Healthy Korean Subjects. [PDF]

Drug Des Devel Ther
Kang J, Bae S, Yu KS, Lee S.
europepmc   +1 more source

White Matter Dysfunction and Neurotransmitter Basis Underlying the Freezing of Gait in Parkinson's Disease

iNew Medicine, EarlyView.
In the freezing of gait in Parkinson's disease, white matter shows decreased local activity but increased functional connectivity. These distinct dysfunctions are uniquely associated with specific neurotransmitter systems (GABA, dopamine, etc.), mapping a new neurochemical basis for this debilitating symptom. ABSTRACT Freezing of gait (FOG) is a severe
Pingping Liu, Jinmei Sun, Lili Hu, Xin Chen, Jinying Han, Liuzhenxiong Yu, Siyu Fan, Rong Ye, Kai Wang, Gong‐Jun Ji, Panpan Hu   +10 more
wiley   +1 more source

Oncolytic HSV-1 expressing GM-CSF and IL-12 enhances anti-tumor efficacy in immunocompetent murine melanoma model. [PDF]

Virol Sin
Xiao H, Yin Q, Liu J, Hu H, Li J, Wang M, Hu Z.   +6 more
europepmc   +1 more source

The Role of Endothelin‐1 in Autoimmune Diseases: Mechanistic Insights and Therapeutic Targets

iNew Medicine, EarlyView.
The Role of Endothelin‐1 in Autoimmune Diseases. NF‐κB: nuclear factor kappa‐B; MAPK: mitogen‐activated protein kinase; PI3K: phosphoinositide 3‐kinase; ROS: reactive oxygen species; CTGF: connective tissue growth factor; TGF‐β: transforming growth factor‐β.
Xun Gong, Zhenyu Wang, Suyin Yang, Kaige Gao, Xin Yang, Min Tang   +5 more
wiley   +1 more source

IL-12 and GM-CSF engineered dendritic cells enhance the enrichment and selection of tumor-reactive T cells for cancer immunotherapy. [PDF]

Front Immunol
Liu Z, Li H, Gao Z, Cheng R, Lu J, Che X, Dong J, Wang Z, Cui Z, Gu J, Bai Y, Li C, Liu Y, Wang C, Deng H.   +14 more
europepmc   +1 more source

Holistic bone developing microenvironment engineered apoptotic extracellular vesicles recapitulate multidimensional developmental signatures in adult and senile bone repair

Interdisciplinary Medicine, EarlyView.
The developing bone was identified as an M2a‐like macrophage driven immune microenvironment with multidimensional developmental signatures. hME‐ApoEVs were successfully fabricated via stimulating the M2a‐like developing microenvironment in vitro and confirmed its recapitulation of developmental features.
Xiaoran Yu, Jieyun Xu, Yuan Zhao, Xinyu Guo, Hongcheng Chen, Junlong Xue, Yong Ao, Linjun Zhang, Xiaomeng Gao, Xueli Mao, Songtao Shi, Zetao Chen   +11 more
wiley   +1 more source

GM-CSF potentiates macrophages to retain an inflammatory feature from their circulating monocyte precursors in rheumatoid arthritis. [PDF]

J Transl Med
Chen J, Zhan M, Zhao Y, Xu H, Feng F, Bai Z, Zhang K, Fu L, Wang F, Cheng Y, Zhang X, Liu Y.   +11 more
europepmc   +1 more source

The Role of Magnetic Resonance Spectroscopy (MRS), Diffusion‐Tensor‐Imaging (DTI) and Structural MRI in the Alzheimer's Disease and Mild Cognitive Impairment Diagnosis: A Review

Journal of Magnetic Resonance Imaging, EarlyView.
ABSTRACT Alzheimer's disease (AD) is one of the most common neurological disorders affecting older adults, with approximately 7.2 million cases only in the United States. This number is projected to increase to 13.8 million in the United States by 2060, leading to increased expenditures for healthcare, long‐term care and hospice services. Consequently,
Valentina Zecca, Gianmauro Palombelli, Nicola Vanacore, Rossella Canese   +3 more
wiley   +1 more source