Results 61 to 70 of about 195,338 (284)

GM-CSF Inhibits c-Kit and SCF Expression by Bone Marrow-Derived Dendritic Cells. [PDF]

, 2017
Stem cell factor (SCF), the ligand of c-kit, is a key cytokine for hematopoiesis. Hematopoietic precursors express c-kit, whereas differentiated cells of hematopoietic lineage are negative for this receptor, with the exception of NK cells, mast cells ...
Adachi, Alloatti, Ashman, Balan, Banchereau, Bar-On, Barnden, Bonetti, Borg, Breton, Broudy, Broz, Burgdorf, Cavanagh, Cebrian, Di Rosa, Dubois, Eash, Filippi, Gallucci, Guilliams, Haniffa, Heinrich, Helft, Hogquist, Hotchkiss, Huang, Inaba, Kassianos, Kingston, Krishnamoorthy, Lacombe, Lennartsson, Li, Liu, Liu, Lundberg, Lundberg, Lutz, Mensen, Merad, Merad, Mildner, Miller, Nagase, Nair, Oriss, Palucka, Parretta, Pastille, Politikos, Ponzetta, Quinci, Reber, Reith, Ricart, Roskoski, Russell, Saft, Sallusto, Sallusto, Sapoznikov, Sathe, Shortman, Sozzani, Sozzani, Szyska, Testa, van de Laar, von Bonin, Vremec, Wang, Waskow, Welham, Welker, Yang, Yen, Zanoni, Zelenay, Zou   +79 more
core   +2 more sources

Insights Into the Antigenic Repertoire of Unclassified Synaptic Antibodies

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective We sought to characterize the sixth most common finding in our neuroimmunological laboratory practice (tissue assay‐observed unclassified neural antibodies [UNAs]), combining protein microarray and phage immunoprecipitation sequencing (PhIP‐Seq). Methods Patient specimens (258; 133 serums; 125 CSF) meeting UNA criteria were profiled;
Michael Gilligan, John R. Mills, Paulina Vargas, Naveen K. Paramasivan, Connie E. Lesnick, Eati Basal, Surendra Dasari, James P. Fryer, Shannon R. Hinson, Joseph Laporta, Amy Espinal, Dennis Fitzgerald, Carolina Garcia, Anna E. Morenkova, Paola Pergami, Anna Shah, Andrew Knight, Reghann LaFrance Corey, Vanda A. Lennon, Anastasia Zekeridou, Sean J. Pittock, Divyanshu Dubey, Andrew McKeon   +22 more
wiley   +1 more source

CREB regulates TNF-α-induced GM-CSF secretion via p38 MAPK in human lung fibroblasts

Allergology International, 2016
Background: Granulocyte-macrophage colony-stimulating factor (GM-CSF) is a cytokine that mediates eosinophilic differentiation, migration and survival, causing respiratory tract inflammation.
Yasuhiko Koga, Takeshi Hisada, Tamotsu Ishizuka, Mitsuyoshi Utsugi, Akihiro Ono, Masakiyo Yatomi, Yosuke Kamide, Haruka Aoki-Saito, Hiroaki Tsurumaki, Kunio Dobashi, Masanobu Yamada   +10 more
doaj   +1 more source

Sca-1+ cardiac fibroblasts promote development of heart failure [PDF]

, 2018
The causative effect of GM-CSF produced by cardiac fibroblasts to development of heart failure has not been shown. We identified the pathological GM-CSF-producing cardiac fibroblast subset and the specific deletion of IL-17A signaling to these cells ...
Bracamonte-Baran, William, Chen, Guobao, Conway, Simon J., Davogustto, Giovanni, Diny, Nicola L., Frazier, O. Howard, Fu, Kai, Hou, Xuezhou, Liu, Yue, Taegtmeyer, Heinrich, Talor, Monica V., Vasquez, Hernan, Waisman, Ari, Wan, Fengyi, Čiháková, Daniela   +14 more
core   +1 more source

Spinal Cord Infarction Versus Idiopathic Transverse Myelitis: Clinical, Radiological, and Functional Insights From a Retrospective Cohort Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Introduction Spinal cord infarction (SCI) is a rare but devastating myelopathy, characterized by a high disability rate and an unfavorable prognosis. It has often been underdiagnosed and misdiagnosed as idiopathic transverse myelitis (ITM). This study aimed to describe the clinical features, radiological biomarkers, treatments, and functional ...
Zeqiang Ji, Jianlong Zhang, Yiming Shi, Shiyu Shan, Yang Du, Guangshuo Li, Ying Jin, Yani Zhang, Chuanying Wang, Yijun Lin, Yuhao Guo, Decai Tian, Xingquan Zhao, Tian Song   +13 more
wiley   +1 more source

Rituximab therapy in pulmonary alveolar proteinosis improves alveolar macrophage lipid homeostasis [PDF]

, 2012
Rationale Pulmonary Alveolar Proteinosis (PAP) patients exhibit an acquired deficiency of biologically active granulocyte-macrophage colony stimulating factor (GM-CSF) attributable to GM-CSF specific autoantibodies. PAP alveolar macrophages are foamy,
Barna, Barbara P, Huizar, Isham, Karnekar, Reema, Kavuru, Mani S, Malur, Anagha, Marshall, Irene, NC DOCKS at East Carolina University, Thomassen, Mary Jane   +7 more
core   +3 more sources

The Cloning of GM-CSF [PDF]

The Journal of Immunology, 2017
With the cloning of the cDNA encoding murine GM-CSF in 1984, Dunn and colleagues ([1][1]) ushered the power of recombinant DNA technology into the exploration of the biology of this multifaceted cytokine.
openaire   +2 more sources

Meningovascular Inflammation in Cerebral Amyloid Angiopathy‐Related Cortical Superficial Siderosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT The role of inflammation in cortical superficial siderosis (cSS), a marker of cerebral amyloid angiopathy (CAA) linked to high hemorrhage risk, is unclear. We examined 15 patients with cSS using 3 T post‐contrast vessel wall MRI (VWI) and CSF analysis.
Philipp Arndt, Eya Khadhraoui, Sebastian J. Müller, Katja Neumann, Hendrik Mattern, Sven G. Meuth, Valentina Perosa, Andreas Charidimou, Stefanie Schreiber   +8 more
wiley   +1 more source

Increased IL-2 and Reduced TGF-β Upon T-Cell Stimulation are Associated with GM-CSF Upregulation in Multiple Immune Cell Types in Multiple Sclerosis

Biomedicines, 2020
Granulocyte macrophage colony stimulating factor (GM-CSF) is a pro-inflammatory cytokine produced by immune cells. Recent evidence suggests that GM-CSF plays an important role in multiple sclerosis (MS) pathogenesis.
Jehan Aram, Nanci Frakich, Elena Morandi, Mohammed Alrouji, Amal Samaraweera, David Onion, Ian Spendlove, Sergio L. Colombo, Radu Tanasescu, Bruno Gran, Cris S. Constantinescu   +10 more
doaj   +1 more source

An exploratory study investigating biomarkers associated with autoimmune pulmonary alveolar proteinosis (aPAP)

Scientific Reports, 2022
Autoimmune pulmonary alveolar proteinosis (aPAP) is a rare lung disorder involving production of autoantibodies against endogenous granulocyte–macrophage colony-stimulating factor (GM-CSF).
Ilaria Campo, Federica Meloni, Martina Gahlemann, Wiebke Sauter, Carina Ittrich, Corinna Schoelch, Bruce C. Trapnell, Abhya Gupta   +7 more
doaj   +1 more source