Results 51 to 60 of about 1,222 (163)

Generalized Modules for Membrane Antigens as Carrier for Polysaccharides: Impact of Sugar Length, Density, and Attachment Site on the Immune Response Elicited in Animal Models

Frontiers in Immunology, 2021
Nanoparticle systems are being explored for the display of carbohydrate antigens, characterized by multimeric presentation of glycan epitopes and special chemico-physical properties of nano-sized particles.
Francesca Micoli, Renzo Alfini, Roberta Di Benedetto, Francesca Necchi, Fabiola Schiavo, Francesca Mancini, Martina Carducci, Davide Oldrini, Olimpia Pitirollo, Gianmarco Gasperini, Cristiana Balocchi, Nicoletta Bechi, Brunella Brunelli, Diego Piccioli, Roberto Adamo   +14 more
doaj   +1 more source

A Decade of the Global STI Vaccine Roadmap: Progress, Gaps and Challenges. [PDF]

J Int AIDS Soc
Journal of the International AIDS Society, Volume 29, Issue S2, July 2026.
Peters RPH, Delany-Moretlwe S, Seib KL, Giersing B, Gottlieb SL.   +4 more
europepmc   +2 more sources

Stability of Outer Membrane Vesicles-Based Vaccines, Identifying the Most Appropriate Methods to Detect Changes in Vaccine Potency

Vaccines, 2021
Ensuring the stability of vaccines is crucial to successfully performing global immunization programs. Outer Membrane Vesicles (OMV) are receiving great attention as vaccine platforms.
Elena Palmieri, Vanessa Arato, Davide Oldrini, Beatrice Ricchetti, Maria Grazia Aruta, Werner Pansegrau, Sara Marchi, Fabiola Giusti, Ilaria Ferlenghi, Omar Rossi, Renzo Alfini, Carlo Giannelli, Gianmarco Gasperini, Francesca Necchi, Francesca Micoli   +14 more
doaj   +1 more source

Damage Modelling of Compressed Earth Blocks Stabilised with Cement

Advances in Civil Engineering, 2022
This work aims at studying the mechanical behaviour of compressed Earth blocks (CEBs) and compressed stabilised Earth blocks (CSEBs) with 4% and 8% in weight cement stabilisation.
Janvier Goutsaya, Guy Edgar Ntamack, Saâd Charif d’Ouazzane   +2 more
doaj   +1 more source

Using Synthetic Glycans to Investigate Anti-Glycan Antibodies and Explore Their Medical Potential. [PDF]

Angew Chem Int Ed Engl
Anti‐glycan antibodies are essential in health and disease. Access to novel glycan structures paves the way for progress in antibody profiling for biomarker discovery, antibody development, and vaccine design. We summarize the strategies to synthesize and utilize synthetic glycans for the development and application of anti‐glycan antibodies in basic ...
Weber F, Valenti A, Ledvinka J, Moscovitz O, Seeberger PH.   +4 more
europepmc   +2 more sources

Theoretical Investigation of Fast Neutron and Gamma Radiation Properties of Polycarbonate-Bismuth Oxide Composites Using Geant4

Nanomaterials, 2022
The gamma mass (µm) and linear (µ) attenuation coefficients of polycarbonate-bismuth oxide composites (PC-Bi2O3) with different bismuth oxide weight factors were investigated theoretically using EpiXS and a Monte Carlo simulation-based toolkit and Geant4
Hanan Akhdar
doaj   +1 more source

Safety and immunogenicity of the iNTS-GMMA vaccine

, 2023
Invasive non-typhoidal Salmonella (iNTS) is a common cause of bacteraemia in sub-Saharan Africa, where it particularly affects children under five. In this thesis, I outline SALVO (Salmonella Vaccine Study in Oxford), a first-in-human phase I randomised placebo-controlled trial investigating the safety and immunogenicity of the iNTS-GMMA vaccine at two
openaire   +2 more sources

Outer membrane vesicles: moving within the intricate labyrinth of assays that can predict risks of reactogenicity in humans

Human Vaccines & Immunotherapeutics, 2021
Outer membrane vesicles (OMV) are exosomes naturally released from the surface of Gram-negative bacteria. Since the ’80s, OMVs have been proposed as powerful vaccine platforms due to their intrinsic self-adjuvanticity and ability to present multiple ...
Omar Rossi, Francesco Citiulo, Francesca Mancini   +2 more
doaj   +1 more source

Efficacy, safety, and immunogenicity of the Shigella sonnei 1790GAHB GMMA candidate vaccine: Results from a phase 2b randomized, placebo-controlled challenge study in adults

EClinicalMedicine, 2021
Background Shigellosis accounts for substantial morbidity and mortality worldwide and is the second most common cause of moderate and severe diarrhoea in children. Methods This phase 2b study (NCT03527173), conducted between August 2018 and November 2019,
R. Frenck, V. Conti, P. Ferruzzi, Augustin G. W. Ndiaye, Susan Parker, M. McNeal, M. Dickey, J. Granada, Giulia Luna Cilio, Iris De Ryck, Francesca Necchi, Akamol E Suvarnapunya, O. Rossi, A. Acquaviva, L. Chandrasekaran, Kristen A. Clarkson, Joachim Auerbach, E. Marchetti, Robert W. Kaminski, F. Micoli, R. Rappuoli, A. Saul, Laura B. Martin, A. Podda   +23 more
semanticscholar   +1 more source

Complement-mediated serum bactericidal activity of antibodies elicited by the Shigella sonnei GMMA vaccine in adults from a shigellosis-endemic country: Exploratory analysis of a Phase 2a randomized study

Frontiers in Immunology, 2022
Shigella is associated with a significant burden of disease worldwide among individuals of all ages and is the major cause of moderate and severe diarrhea in children under five years of age in low- and middle-income countries. Several candidate vaccines
M. Kapulu, U. Nakakana, A. S. Sciré, Eleanna Sarakinou, V. Conti, O. Rossi, A. Acquaviva, Francesca Necchi, Christina W. Obiero, Laura B. Martin, Philip Bejon, P. Njuguna, F. Micoli, A. Podda   +13 more
semanticscholar   +1 more source