Results 91 to 100 of about 157,757 (356)

Magnetically Driven Biofabrication for Tissue Engineering: From Nanoparticle Design to Mag‐ATMP Translation

Advanced Healthcare Materials, EarlyView.
Magnetically responsive nanoparticles enable remote control over biomaterials, cells, and engineered tissues. This review summarizes material design, biological safety, fabrication and actuation strategies, computational validation, and translational pathways that support the development of magnetic tissue‐engineering platforms and future magnetically ...
Konstantinos Ioannidis, Dimitrios Lefas, Maya Guilliams, Jackie Van Grootenbril, Isaak Decoene, Dimitrios Sakellariou, Bart Smeets, Stefanos Mourdikoudis, Ioannis Papantoniou   +8 more
wiley   +1 more source

Cognate Interaction With CD4+ T Cells Instructs Tumor-Associated Macrophages to Acquire M1-Like Phenotype

Frontiers in Immunology, 2019
The immunosuppressive tumor microenvironment (TME) established by tumor cells, stromal cells and inhibitory immune cells counteracts the function of tumor reactive T cells.
David Eisel, David Eisel, David Eisel, Krishna Das, Krishna Das, Krishna Das, Elke Dickes, Rainer König, Wolfram Osen, Stefan B. Eichmüller   +9 more
doaj   +1 more source

Cyclic-di-GMP regulation promotes survival of a slow-replicating subpopulation of intracellular Salmonella Typhimurium

Proceedings of the National Academy of Sciences of the United States of America, 2019
Significance Cyclic di-GMP is a bacterial second messenger that transmits extracellular signals to the intracellular environment via sensor cyclic-di-GMP−metabolizing enzymes.
Erik Petersen, Erez Mills, Samuel I. Miller   +2 more
semanticscholar   +1 more source

A Chemical Framework for Engineering Extracellular Vesicles’ Biointerface to Advance Precision Therapeutics

Advanced Materials, EarlyView.
Extracellular vesicles (EVs) are cell‐derived nanoparticles that mediate intercellular communication through their dynamic biointerfaces. Owing to their intrinsic biological functions, EVs have emerged as promising platforms for biomedical applications.
Leila Pourtalebi Jahromi, Felix Geng, Jan‐Noël Frenzke, Gregor Fuhrmann   +3 more
wiley   +1 more source

First‐In‐Human Application of Human Umbilical Cord‐Derived Extracellular Vesicles in Tethered Spinal Cord Release Surgery

Journal of Extracellular Vesicles
Spina bifida is a congenital neural tube defect that has a high risk of secondary neurological deterioration due to tethering of the spinal cord.
Matthias Krause, Janina Gburek‐Augustat, Daniel Gräfe, Roman Metzger, Marco Ginzel, Christoph J. Griessenauer, Lukas Grassner, Daniel Weghuber, Johann Gradl, Daniela Auer, Tanja Schally, Stefan Rund, Carina Kals, Christina Folie, Elisabeth Bayer, Mario Gimona, Eva Rohde   +16 more
doaj   +1 more source

Cyclic GMP-AMP Containing Mixed Phosphodiester Linkages Is An Endogenous High Affinity Ligand for STING

Molecules and Cells, 2013
The presence of microbial or self DNA in the cytoplasm of mammalian cells is a danger signal detected by the DNA sensor cyclic-GMP-AMP (cGAMP) synthase (cGAS), which catalyzes the production of cGAMP that in turn serves as a second messenger to activate ...
Xu Zhang, Heping Shi, Jiaxi Wu, Xuewu Zhang, Lijun Sun, Chuo Chen, Zhijian J. Chen   +6 more
semanticscholar   +1 more source

Intelligent Micro/Nanorobots for Targeted Interventional Therapy: From Bench to Clinic

Advanced Robotics Research, EarlyView.
Zirui Zhang et al. reviewed the application and challenges of mobile nanomachines in interventional therapy. By converting exogenous energy, including chemical, magnetic, optical, and ultrasonic sources, into mechanical forces, micro/nanorobots (MNRs) enable precise actuation at unprecedented scales. Evolving far beyond traditional drug delivery, these
Zirui Zhang, Yu Dong, Yongsheng Du, Rui Gao, Lin Zhang, Fei Tong   +5 more
wiley   +1 more source

Flagellar Stators Stimulate c-di-GMP Production by Pseudomonas aeruginosa

bioRxiv, 2018
The ability of bacterial cells to control motility during early steps in biofilm formation is critical for the transition to a nonmotile, biofilm lifestyle. Recent studies have clearly demonstrated the ability of c-di-GMP to control motility via a number
Amy E. Baker, Shanice S. Webster, Andreas Diepold, S. Kuchma, Eric Bordeleau, J. Armitage, G. O’Toole   +6 more
semanticscholar   +1 more source

Digital image processing of optical density wave propagation in Dictyostelium discoideum and analysis of the effects of caffeine and ammonia [PDF]

, 1989
Waves of chemotactic movement during the early phase of aggregation in Dictyostelium discoideum were analyzed by digital image processing in a manner that immediately shows the following parameters: wave propagation velocity, period length, wave ...
Siegert, Florian, Weijer, Cornelis J.
core   +1 more source

FleQ, FleN and c-di-GMP coordinately regulate cellulose production in Pseudomonas syringae pv. tomato DC3000

, 2023
The second messenger cyclic di-GMP (c-di-GMP) controls the transition between motility and sessility in many bacterial species by a variety of mechanisms, including the production of multiple exopolysaccharides. Pseudomonas syringae pv.
López-Sánchez, Aroa, Gallegos, María Trinidad, García Alcaide, A., Govantes, Fernando, López Sánchez, Aroa, García-Alcaide, Andrea, Martínez-Rodríguez, Laura   +6 more
core   +1 more source