Results 91 to 100 of about 117,081 (314)

Natural‐Inspired Engineered Microalgae With Selenium Enrichment Enabled Potent Anti‐Tumor Immunity

Advanced Science, EarlyView.
Se‐Ssp was engineered as a potent immunomodulator for activating innate immunity via the TLR and cGAS‐STING pathways, therefore converting “cold” tumors into “hot” tumors to achieve high efficacy and long‐term therapeutic outcomes. ABSTRACT Immunotherapy has shed light on clinical oncology for several decades.
Yuqi Yang, Xiaowei Cai, Xiaoyan Zhong, Tian Qiu, Qinwei Lu, Jiahao Qin, Fei Gong, Yecheng Huang, Chenyu Jiang, Youdong Chen, Yuan Cheng, Liang Cheng   +11 more
wiley   +1 more source

Targeting β2‐Adrenergic Receptor Stability With Lycorine Reveals a Host‐Directed Pathway for Antiviral Defense Against Poxviruses

Advanced Science, EarlyView.
Chronic stress drives autophagy‐mediated β2‐AR degradation, impairing antiviral immunity and promoting poxvirus lethality. Lycorine directly stabilizes β2‐AR to restore host defense, suppress excessive inflammation and improve survival. ABSTRACT Psychological stress is a pervasive yet poorly understood modulator of infectious disease outcomes. Here, we
Xin Zhang, Shuqin Xu, Zixuan Zhang, Chenwen Wan, Xiaoqin Wang, Peihua Wang, Huini Yang, Tianxiao Huang, Yijia Yuan, Faiza Atique, Rui Yang, Yingli He, Zhijun Liu   +12 more
wiley   +1 more source

gmp in China [PDF]

, 2016
GMP IN CHINA Baunetzwoche (Rights reserved) (-) Ausgabe 451.2016 gmp in China (Rights reserved) (-

core  

Aplikasi GMP dalam Produksi Garam Konsumsi Beryodium [PDF]

, 2016
The main  objective  of  Good  Manufacturing  Practise  (GMP) implementation  is products with quality, nutrition and  for all consumers. GMP implementation  is guided by the regulation of health minister (SK. Menteri   Kesehatan   No.
Lestari, Nami, Nami Lestari
core   +1 more source

KLF5 Downregulation Links Impaired BNIP3‐Mediated Mitophagy to Inflammatory Valve Remodeling in Calcific Aortic Valve Disease

Advanced Science, EarlyView.
In human CAVD, KLF5 is reduced in VIC‐rich regions and remodeling/stress‐associated VIC states. In VICs, KLF5 sustains BNIP3 promoter activity and BNIP3‐mediated mitophagy, thereby limiting cytosolic mtDNA accumulation. KLF5 loss weakens mitochondrial quality control and enhances mtDNA‐sensitive STING/NF‐κB/NLRP3 inflammatory signaling under osteogenic
Jin‐Hui Bian, Jia‐Xi Gu, Zhang Yue, Chun‐Ze Yuan, Hai‐Bin Ji, Ao Li, Yu Zhong, Xiu‐Fan Xu, Yu‐Qiu He, Ye‐Fan Jiang, Hong‐Shan Chen, Xiang Chen, Meng‐Lin Chao, Yong‐Feng Shao   +13 more
wiley   +1 more source

Macrophage RSAD2 Couples mtDNA Synthesis With a Self‐Amplifying Inflammatory Circuit to Orchestrate Tissue Repair

Advanced Science, EarlyView.
Macrophage RSAD2 dually regulates CMPK2—the rate‐limiting enzyme for mitochondrial DNA synthesis—by suppressing its ubiquitination and promoting its phosphorylation via Csnk2a2 recruitment. This amplifies mtDNA production, which simultaneously activates a cGAS‐STING‐IRF3‐RSAD2 feedforward loop and the NLRP3 inflammasome, driving a self‐sustaining ...
Haomiao Yuan, Shukui Du, Chunfei Li, Xinjie Li, Shuyang Mu, Anran Qu, Hengxu Yan, Chongchong Xu, Jinnong Yang, Jingkai Sun, Yijun Wang, Jiayang Xiao, Fuyuan Zhang, Linlin Wang, Tiegang Li, Rui Zhao, Dawei Guan   +16 more
wiley   +1 more source

Processing Performance and Economic Feasibility Profile of Jambal Roti Salted Fish in Pangandaran, West Java

Grouper
Pangandaran's abundant fishery resources require proper processing to prevent rapid spoilage, making preservation through jambal roti salted fish production crucial for both food security and local livelihoods.
Ananda Dwi Septian, Iwang Gumilar, Nora Akbarsyah, Ine Maulina   +3 more
doaj   +1 more source

Fish commercialization in the main market places in Monteria, Colombia

Temas Agrarios, 2014
Fish commercialization in Colombia has increased in the last few years, due to benefits associated to its consumption. In Monteria city, most of the fish is sold in public market places, where currently the state of its commercialization is unknown.
Elvira Durán, Robinson R. Rosado, Oscar D. Ballesteros, David E. Lerma   +3 more
doaj   +1 more source

The First FRET-Based RNA Aptamer NanoKit for Sensitively and Specifically Detecting c‑di-GMP

An effective method to identify c-di-GMP may significantly facilitate the exploration of its signaling pathways and bacterial pathogenesis. Herein, we have developed the first conjugated polymer-amplified RNA aptamer NanoKit with a unique core–shell ...
Xinghai Ning (1372887), Yanyan Li (345271), Ya Gao (526722), Yuhang Liu (507131), Xiaotong Wu (5216231), Kerong Chen (4794003), Desheng Kong (40291), Yurui Xu (3777769), Xuli Feng (2405239)   +8 more
core   +1 more source

Design and Application of Nanozymes: Current Trends and Cutting‐Edge Breakthroughs

Advanced Science, EarlyView.
Kelong Fan, Hui Wei, Xiyun Yan
wiley   +1 more source