Results 81 to 90 of about 117,081 (314)

Versatile Co‐Engineering of Immunogenic Cell Death‐Primed Dead Tumor Cell Bodies With Tumor‐Activated MnO2 for cGAS‐STING‐Potentiated Personalized Immunotherapy

Advanced Science, EarlyView.
DTBEI@CS@MnO2, fabricated via modular electrostatic co‐engineering and photothermal/photodynamic immunogenic cell death, specifically responds to the acidic and GSH‐rich tumor microenvironment. This triggers the release of DTBEI that provides tumor antigens, DNA, and DAMPs, as well as the generation of Mn2+, thereby synergistically potentiating cGAS ...
Bolun Xu, Xuan Lu, Yuquan Wang, Haihua Ji, Ying Zhang, Yiqun Wan, Hao Wan   +6 more
wiley   +1 more source

Legal and Regulatory Aspects of Compounding Radiopharmaceutical Medicinal Products in Healthcare Organizations of the Republic of Kazakhstan

Регуляторные исследования и экспертиза лекарственных средств
INTRODUCTION. The current regulatory framework of the Republic of Kazakhstan does not provide for a special legal regime governing the compounding and circulation of radiopharmaceutical medicinal products (RMPs) in healthcare organizations.
A. N. Gurin, G. E. Kodina, Y. T. Chakrova, I. K. Tleulessova, N. V. Pyatigorskaya, M. G. Grinin   +5 more
doaj   +1 more source

Real-time PCR for traceability and quantification of genetically modified seeds in lots of non-transgenic soybean

Bioscience Journal, 2017
The constant presence of genetically modified (GM) soybean in conventional seed lots has become a growing problem for international seed trade. In this context, seed companies have prompted the development of routine tests for accurate genetically ...
Joelma Leão-Buchir, Gilberto Vinícius Melo Pereira, André Luís Lopes da Silva, Silvana Alban, Maria Carolina Rocha, Jossimara Polettini, Vanete Thomaz-Soccol, Carlos Ricardo Soccol   +7 more
doaj   +1 more source

O efeito trófico dos derivados da guanina em culturas de astrócitos e neurônios cerebelares [PDF]

, 2006
Dissertação (mestrado) - Universidade Federal de Santa Catarina. Centro de Ciências Biológicas. Programa de Pós-Graduação em Neurociências.Neste estudo foi avaliado o efeito de GMP ou Guanosina em três diferentes situações: o efeito trófico sobre ...
Decker, Helena
core  

Iron‐Tannic Acid Hydrogel Mediated Mild Photothermal Therapy Combined With Ferroptosis Enhances Anti‐Tumor Immunity in Colorectal Cancer

Advanced Science, EarlyView.
An injectable gelatin‐based tannic acid–iron hydrogel with mild photothermal therapy could not only induce immunogenic cell death, but also elicit ferroptosis of both tumor cells and tumor‐associated macrophages, resulting in DC maturation, T‐cell infiltration and down‐regulation of ferroptosis‐sensitive M2‐type TAMs levels.
Yuan Zhu, Xi Yu, Tao Wang, Wanyi Liu, Chang Lu, Jiani Zhong, Yujie He, Wei Li, Kunxi Zhang, Peihao Yin, Zeting Yuan   +10 more
wiley   +1 more source

Assessing the Correlation Between GMP Deviations and Potential Quality Defects of Medicinal Products: the Result of the Survey of Qualified Persons

Разработка и регистрация лекарственных средств, 2020
Introduction. One of the key issues in the field of assessing the conformity of drug manufacturers with the requirements of good manufacturing practice (GMP) is a systematic methodology for classifying revealed deficiencies (deviations, non-conformities)
V. A. Orlov, V. N. Shestakov
doaj   +1 more source

Image1_FleQ, FleN and c-di-GMP coordinately regulate cellulose production in Pseudomonas syringae pv. tomato DC3000.TIF

, 2023
The second messenger cyclic di-GMP (c-di-GMP) controls the transition between motility and sessility in many bacterial species by a variety of mechanisms, including the production of multiple exopolysaccharides. Pseudomonas syringae pv.
María-Trinidad Gallegos (535322), Andrea García-Alcaide (14843236), López-Sánchez, Aroa, Fernando Govantes (3124044), Gallegos, María Trinidad, Aroa López-Sánchez (3124047), García Alcaide, A., Govantes, Fernando, Laura Martínez-Rodríguez (819714), Martínez-Rodríguez, Laura   +9 more
core   +1 more source

SR‐A3 Promotes USP18‐Mediated deISGylation of STING to Protect Against Myocardial Ischemia‐Reperfusion Injury

Advanced Science, EarlyView.
MI/RI is a major clinical challenge with high morbidity and mortality. This study demonstrates that SR‐A3 expression is downregulated in MI/RI, and its deletion exacerbates damage via the USP18/ISG15/STING axis, revealing SR‐A3 as a potential therapeutic target.
Yufei Han, Guolin Miao, Yinqi Zhao, Zhiyong Du, Kaikai Lu, Changqi Xiao, Aiden Xian, Jiaxin Duanmu, Zihao Zhou, Jinxuan Chen, Lianxin Zhang, Chao Zhai, Yitong Xu, Zhaoling Li, Xianqin Shen, Sijing Shi, Jingxuan Chen, Si Mei, Yuan Fang, Liwen Zheng, Ling Zhang, Yuhui Wang, Wei Huang, Erdan Dong, Xunde Xian   +24 more
wiley   +1 more source

ROS‐Responsive Eye Drop for Controlled Release of 20‐Deoxyingenol Improves Diabetic Corneal Healing by Activating Macrophage Autophagy and Metabolic Reprogramming

Advanced Science, EarlyView.
Schematic illustration of ROS‐responsive TSPBA‐PVA microspheres loaded with 20‐deoxyingenol (TP/20‐DOI) for diabetic corneal wound healing: (a) fabrication and ROS‐triggered release; (b) autophagy activation and metabolic reprogramming in macrophages; (c) suppression of macrophage‐derived CXCL3/CXCL5, attenuation of neutrophil infiltration, and ...
Jiaxin Wu, Wanying Chen, Haijiang Qiu, Weihan Zheng, Ying Jiao, Jingheng Du, Zhudan Zhuang, Xing Hua, Jingyi Gu, Yuheng Liu, Zhaojin Li, Jingbin Xie, Hanxiao Sun, Huifei Lan, Xin Sun, Yunxia Xue, Ting Fu, Zhijie Li, Guobing Chen, Shiyu Li, Jun Liu   +20 more
wiley   +1 more source

Factors of quality management system influencing organizational performance: A study of pharmaceutical factories getting GMP certificate in Vietnam

Ho Chi Minh City Open University Journal of Science - Economics and Business Administration, 2016
A study objective is to identify key factors of QMS (Quality Management System) influencing the organizational performance in pharmaceutical factories getting GMP (Good Manufacturing Practices) certificate.
Nguyen Thuy Quynh Loan
doaj   +1 more source