Results 81 to 90 of about 157,757 (356)

More than Enzymes That Make or Break Cyclic Di-GMP—Local Signaling in the Interactome of GGDEF/EAL Domain Proteins of Escherichia coli

mBio, 2017
The bacterial second messenger bis-(3′-5′)-cyclic diguanosine monophosphate (c-di-GMP) ubiquitously promotes bacterial biofilm formation. Intracellular pools of c-di-GMP seem to be dynamically negotiated by diguanylate cyclases (DGCs, with GGDEF domains)
Olga Sarenko, Gisela Klauck, F. Wilke, Vanessa Pfiffer, A. M. Richter, S. Herbst, V. Kaever, R. Hengge   +7 more
semanticscholar   +1 more source

On the interaction of cationic compounds with ABC-transporters and lipid membranes [PDF]

, 2012
This thesis aimed at revealing the substrate specificity of the bacterial ABC-transporter, Sav1866. For this purpose the ABC-transporter was reconstituted into model membranes and characterized in terms of basal and drug induced ATPase activity ...
Beck, Andreas
core   +1 more source

From Cell‐Derived Vesicles to Hybrid Nanovectors: Biological Membranes as Functional Blueprints for Gene Delivery

Advanced Healthcare Materials, EarlyView.
Biologically derived and hybrid nonviral nanovectors are examined as distinct but convergent design approaches. Integrating synthetic components with biologically functionalized membranes allows efficient interactions with complex cellular environments.
Clara Baldari, Claudia Leone, Gabriella Leccese, Claudia De Stradis, Alessandra Invidia, Concetta Quintarelli, Biagio De Angelis, Franco Locatelli, Giuseppe Gigli, Gabriele Maiorano, Ilaria Elena Palamà   +10 more
wiley   +1 more source

PROBLEMS OF CONFORMITY OF THE RECORDS INTEGRITY WITH THE REQUIREMENTS OF GOOD MANUFACTURING PRACTICE. REPORT 1. ACTUALITY OF THE RECORDS INTEGRITY CONSERVATION

Разработка и регистрация лекарственных средств, 2019
Integrity of records or data integrity is the most «hot» requirement when assessing documentation systems for compliance with Good Manufacturing Practice (GMP). It's in the center of focus of attention during inspections of pharmaceutical companies. This
I. A. Osmolovskaya, O. V. Zarochinskaya, M. O. Emelianov, D. V. Somov   +3 more
doaj  

Development of Retraining Systems for the Implementation of the Pharmaceutical Quality System at Pharmaceutical Production Enterprises of the EAEU Countries

Разработка и регистрация лекарственных средств, 2021
Introduction. The publication discusses the state and problems of personnel retraining in the implementation of the pharmaceutical quality system at pharmaceutical enter-prises of the Eurasian Union (EU) countries.Aim.
V. A. Smirnov, V. V. Goryachkin, V. N. Shestakov, R. A. Abramovich   +3 more
doaj   +1 more source

Pleiotropic Effects of c-di-GMP Content in Pseudomonas syringae

Applied and Environmental Microbiology, 2019
The present work comprehensively analyzed the transcriptome and phenotypes that were regulated by c-di-GMP in P. syringae. Given that the majority of diguanylate cyclases and phosphodiesterases have not been characterized in P.
Tingting Wang, Zhao Cai, Xiaolong Shao, Weitong Zhang, Yingpeng Xie, Yingchao Zhang, Canfeng Hua, S. Schuster, Liang Yang, Xin Deng   +9 more
semanticscholar   +1 more source

Targeting CD300a Signaling With a Phosphatidylserine‐Presenting Hydrogel Rescues Macrophage Dysfunction and Accelerates Diabetic Wound Healing

Advanced Healthcare Materials, EarlyView.
Schematic illustration of the proposed mechanism: PEG/RGD‐PSLs mimic apoptotic cells to engage PS receptors (notably CD300a), transducing an inhibitory signal that suppresses the MyD88/NF‐κB pathway, leading to global anti‐inflammatory and pro‐reparative effects.
Lele Wu, Xuetong Hao, Yang Zou, Xinglin Chen, Junyan Kong, Chunning Gu, Wenjie Ma, Zhongjun Yang, Huifen Liu, Mengmeng Liu, Xin Tong   +10 more
wiley   +1 more source

Overview of the validation procedures for a vaccine production: from R;D level to the pre-qualification stage

Vaccine Research, 2015
Just like any other process, vaccine manufacturing procedures are defined as a series of interrelated functions and activities using a variety of specified actions and equipment designed to produce a defined product.
H Kaghazian, D Doroud
doaj  

Analisis HACCP Pada UKM Minuman Siap Saji Aloe Vera (ALOJA) Sebagai Sarana Memenuhi Standar Produksi Pangan Yang Baik

Amerta Nutrition, 2020
Background: BPOM stated that in 2017, small and micro food enterprises were responsible for 49,5 % food borne disease in Indonesia. Indonesian government had provided guidance about good handling standard for food product (GMP) by UU No.18 Tahun 2012 ...
Dimas Bayu Pinandoyo, Asriadi Masnar
doaj   +1 more source

Cyclic GMP-AMP Synthase is an Innate Immune Sensor of HIV and Other Retroviruses

Science, 2013
HIV Detection Is a (c)GAS Despite it being one of the most highly studied viruses, there are still many unknowns when it comes to HIV—including how it triggers the innate immune response. Gao et al. (p.
Daxing Gao, Jiaxi Wu, Youtong Wu, Fenghe Du, Chukwuemika Aroh, Nan Yan, Lijun Sun, Zhijian J. Chen   +7 more
semanticscholar   +1 more source