Results 111 to 120 of about 101,384 (314)

The First FRET-Based RNA Aptamer NanoKit for Sensitively and Specifically Detecting c‑di-GMP

An effective method to identify c-di-GMP may significantly facilitate the exploration of its signaling pathways and bacterial pathogenesis. Herein, we have developed the first conjugated polymer-amplified RNA aptamer NanoKit with a unique core–shell ...
Xinghai Ning (1372887), Yanyan Li (345271), Ya Gao (526722), Yuhang Liu (507131), Xiaotong Wu (5216231), Kerong Chen (4794003), Desheng Kong (40291), Yurui Xu (3777769), Xuli Feng (2405239)   +8 more
core   +1 more source

Regulation of poly-GlcNAc expression and fimbriation in uropathogenic "E. coli" [PDF]

, 2013
The transition of planktonic to sessile lifestyles in bacteria rests upon a tightly controlled program that gets triggered by the environmental composition and whose implementation requires multiple feedback controls. Uropathogenic E.
Hosch, Lucie
core   +1 more source

PIEZO1 is Required for Acute Myeloid Leukemia Progression and Leukemia Stem Cell Maintenance via HIF1A‐SLC7A11 Axis‐Mediated Ferroptosis Defense

Advanced Science, EarlyView.
This study identifies the mechanosensor PIEZO1 as a key factor in promoting acute myeloid leukemia progression and uncovers a ferroptosis defense system mediated by PIEZO1‐HIF1A‐SLC7A11 axis that is essential for leukemia stem cell maintenance. This ferroptotic defense system may represent a unique vulnerability for leukemia stem cells, providing a ...
Tiantian Zhang, Ziyan Cao, Kexin Gao, Shuxin Yao, Yanbing Zheng, Manman Cui, Rong Yin, Guoqiang Han, Jin Hu, Chengyi Wang, Haojian Zhang   +10 more
wiley   +1 more source

FUNGICIDE SENSITIVITY OF XYLARIA ISOLATES ASSOCIATED WITH ROOT AND BASAL STEM ROT OF SUGARCANE

Jurnal Agrotek Tropika
Root and basal stem rot is one of important diseases in sugarcane plantations in South Sumatra and Lampung. This disease is caused by Xylaria sp. The study is aimed to determine the fungicides sensitivity of Xylaria sp.
Rosa Indriani, Tri Maryono, Rusdi Evizal, Joko Prasetyo, Heru Pranata, Saefudin Saefudin   +5 more
doaj   +1 more source

Genetic tools to study c-di-GMP-dependent signaling in Pseudomonas aeruginosa.

, 2017
Pseudomonas aeruginosa infections are often difficult or impossible to treat, mainly due to its ability to form antibiotic-resistant biofilms. Since c-di-GMP signaling strongly influences P.
Livia Leoni, Sarika Vishnu Pawar, Giordano Rampioni   +2 more
core   +1 more source

Nucleic Acid Therapeutics for “Undruggable” Cancer Targets: Mechanisms, Challenges, and Prospects

Advanced Science, EarlyView.
Nucleic acid therapeutics bypass the structural limitations of conventional drugs by targeting mRNA rather than proteins. This review examines how antisense oligonucleotides, siRNAs, miRNAs, aptamers, and mRNA vaccines intervene against historically undruggable oncoproteins including Ras, MYC, and p53, highlighting mechanistic advances, delivery ...
Feng Xu, Ke Wang, Kaizhong Lu, Tianlun Hou, Yuan Chen, Xian Wang, Hongchuan Jin   +6 more
wiley   +1 more source

Pseudomonas aeruginosa PAO1 preferentially grows as aggregates in liquid batch cultures and disperses upon starvation [PDF]

, 2009
In both natural and artificial environments, bacteria predominantly grow in biofilms, and bacteria often disperse from biofilms as freely suspended single-cells.
Klebensberger Janosch, Diane McDougald, Barraud, N, Kjelleberg Staffan, Rice Scott A., Webb, Jeremy S., Rice, Scott A., Kjelleberg, Staffan, Rice, SA, Ausubel, Frederick M., Nicolas Barraud, Klebensberger, J, Schleheck, D, Klebensberger, Janosch, David Schleheck, Schleheck, David, Kjelleberg, S, McDougald Diane, Staffan Kjelleberg, Barraud Nicolas, Webb Jeremy S., Jeremy S Webb, Barraud, Nicolas, Scott A Rice, Schleheck David, McDougald, Diane, McDougald, D, Webb, JS, Janosch Klebensberger   +28 more
core   +1 more source

gmp antibody production

, 2023
Non-GMP Antibody ...
Smith, Bella
core   +1 more source

Targeting KDM3B Elicits Anti‐tumor Immunity by Alleviating SHP1–mediated STING Suppression in Triple–Negative Breast Cancer

Advanced Science, EarlyView.
P3FI–90 treatment targets KDM3B, reshapes the epigenetic landscape, and suppresses SHP1 expression, thereby activating STING–TBK1–IRF3–type I IFN signaling pathway. Consequently, CD8+ T cells are recruited to the tumor site and activated to produce IFN–γ and GZMB, leading to the killing of TNBC cells.
Xiaolong Wang, Wenhao Li, Yifei Wang, Ning Zhang, Bing Chen, Wenjing Zhao, Lijuan Wang, Dan Luo, Qifeng Yang   +8 more
wiley   +1 more source

Comparative analysis of integer factorization algorithms

MANAS: Journal of Engineering, 2015
Integer factorization problem, which is used as the basis in many public key cryptosystem, is generally thought to be hard problem even on a modern computers.
G. Kimsanova, R. Ismailova, R. Sultanov
doaj