Results 131 to 140 of about 117,081 (314)

Sustainable Hydrogel‐Forming Microneedle‐Reservoir Patches for Transdermal Delivery of Hydrophilic Macromolecules: Biopolymers, Green Manufacturing and Translation

Advanced Science, EarlyView.
Hydrogel‐forming microneedle (HFMN)‐reservoir patches provide a modular route for controlled transdermal delivery of hydrophilic biomacromolecules. The platform integrates skin‐barrier penetration, sustainable biopolymers, scalable green manufacturing, hydration‐driven transport, model‐cargo validation, and translational quality requirements.
Siddharth Mohanty, Mehmet Onur Aydogdu, Sijia Kang, Xinbo Li, Mohan Edirisinghe   +4 more
wiley   +1 more source

A Dual‐Functional Nanoplatform Targeting the dsDNA–cGAS Axis to Mitigate Disc Degeneration and Aberrant Innervation

Advanced Science, EarlyView.
RU@PEI‐ZIF integrates dsDNA scavenging with local cGAS inhibition to suppress the dsDNA–cGAS–STING/Netrin‐1 axis in intervertebral disc degeneration. By attenuating nucleus pulposus cell senescence, inflammatory and matrix‐catabolic responses, and pathological sensory innervation, this dual‐functional nanoplatform preserves disc integrity and reduces ...
Zhaojun He, Tianyu Chen, Zezheng Liu, Xinlin Huang, Ruitangbin Jiang, Yihao Liu, Baojing Xu, Yuxiang Li, Kangning Zhao, Huibo Yan, Lei Zhou, Can Liu, Qingchu Li   +12 more
wiley   +1 more source

Specific binding of validated ORFs to c-di-GMP.

, 2015
1 Binding and enzymatic activity is deemed positive if activity has been demonstrated for the purified protein or if mutation of residues required for c-di-GMP binding or enyzmatic activity regulate a c-di-GMP dependent phenotype.(+) = c-di-GMP binding ...
Kevin G. Roelofs (818861), Sarah R. Helman (818862), Christopher J. Jones (531373), Xiaoran Shang (818863), Jonathan R. Goodson (159318), Michael Y. Galperin (67366), Fitnat H. Yildiz (162562), Vincent T. Lee (42515), Mona W. Orr (818864)   +8 more
core   +1 more source

A Biomimetic cRGDyk‐Engineered Platelet Nanoplatform for ACAD11 Delivery to Trigger Pyroptosis in Hepatocellular Carcinoma

Advanced Science, EarlyView.
A biomimetic platelet nanoplatform (OE‐ACAD11@R‐PLT) is developed for targeted hepatocellular carcinoma immunotherapy. By selectively delivering therapeutic plasmids, this system induces mitochondrial dysfunction and triggers robust NLRP3/Caspase‐1/GSDMD‐mediated pyroptosis in tumor cells.
Hongyi Bao, Wei Feng, Wei Zong, Yi Li, Xinyue Qin, Xinyue Wang, Yubo Yang, Guanhua Chen, Yiting Hou, Xuan Tan, Lin Chen, Ming Zhang, Feng Wang   +12 more
wiley   +1 more source

Multifactor Evaluation of Good Manufacturing Practices Implementation on Cuttlefish Products in Cold Storage PPN Brondong, Lamongan

Grouper
This study aims to evaluate the main components of Good Manufacturing Practices (GMP) in the processing of cuttlefish products at the Cold Storage facility of PPN Brondong, Lamongan.
Hikmah Farinsyah, Wahyu Santoso, Gyska Indah Harya   +2 more
doaj   +1 more source

A cyclic GMP-dependent signalling pathway regulates bacterial phytopathogenesis

, 2013
Cyclic guanosine 3',5'-monophosphate (cyclic GMP) is a second messenger whose role in bacterial signalling is poorly understood. A genetic screen in the plant pathogen Xanthomonas campestris (Xcc) identified that XC_0250, which encodes a protein with a ...
Maxwell Dow, J., Yang, Jauo-Guey, Liu, Chung-Liang, An, Shi-Qi, Jauo-Guey Yang, Shan-Ho Chou, Dow, J. Maxwell, Chou, Shan-Ho, Ryan, Robert P., David Swarbreck, An, Shi Qi, Swarbreck, David, Jauo‐Guey Yang, Robert P Ryan, Chou, Shan Ho, J Maxwell Dow, Jane Rogers, Liu, Chung Liang, Shi‐Qi An, Yang, Jauo Guey, Yvonne McCarthy, McCarthy, Yvonne, Chin, Ko-Hsin, Shan‐Ho Chou, Melanie Febrer, Ko‐Hsin Chin, Chung-Liang Liu, Chin, Ko Hsin, Rogers, Jane, Ryan, Robert P, Shi-Qi An, Febrer, Melanie, Chung‐Liang Liu, Ko-Hsin Chin   +33 more
core   +1 more source

Precision Nanomedicine for Traumatic Neural Injury: Functional Paradigms and Translational Frameworks

Advanced Science, EarlyView.
This review presents a pathology‐driven framework unifying nanomedicine across TBI, SCI, and PNI. Epidemiological evidence and comparative single‐cell transcriptomic reanalysis define shared pathological modules, injury‐specific effectors, and therapeutic bottlenecks. Six functional paradigms connect nanomaterial structure and biological fate to injury‐
Mouyuan Sun, Shuangyang Li, Zhixu He, Jingyi Xie, Yaxian Luo, Xuankai Fan, Jingyu Zhang, Luying Qin, Lianjie Peng, Tao Qiu, Tian Zhang, Huiming Wang, Mengfei Yu   +12 more
wiley   +1 more source

Mitochondrial Quality Control in Degenerative Musculoskeletal Diseases: Signaling Networks and Therapeutic Landscapes

Advanced Science, EarlyView.
Mitochondrial quality control (MQC) collapse redefines osteoarthritis, intervertebral disc degeneration, and osteoporosis as disorders of organelle dysfunction. Damaged mitochondria leak mtDNA and metabolites, driving cGAS‐STING inflammation, epigenetic reprogramming, and metabolic memory.
Haiyang Gao, Zhangrong Cheng, Xianglong Chen, Wenbo Wu, Wang Wu, Zimu Yu, Cao Yang, Yukun Zhang   +7 more
wiley   +1 more source

Comparative Analysis Of Integer Factorization Algorithms Using Cpu And Gpu

MANAS: Journal of Engineering, 2017
In this work we have evaluated the running time of four integer factorization algorithms, namely, trial division algorithm, Fermat algorithm, Pollard rho and Brent algorithms.
Rita Ismailova, Rayimbek Sultanov, Gulida Kimsanova   +2 more
doaj  

Long‐Term Expandable Periosteal Organoids Reconstruct a Functional Regenerative Niche That Support Hematopoietic Stem Cell Maintenance and Bone Repair

Advanced Science, EarlyView.
A robust periosteal organoid system enables long‐term expansion while preserving native cellular heterogeneity. These organoids recapitulate functional niche environments, support hematopoietic stem cell maintenance, and attenuate aging‐associated decline ex vivo.
Jia Qing, Lanxin Gu, Lipeng Fu, Xin Gao, Zechuan Li, Hui Zhang, Wenpeng Song, Huixin Lv, Yongsheng Zhou, Ping Zhang   +9 more
wiley   +1 more source