Results 131 to 140 of about 157,757 (356)

HpoR, a novel c-di-GMP effective transcription factor, links the second messenger’s regulatory function to the mycobacterial antioxidant defense

Nucleic Acids Research, 2018
Cyclic di-GMP (c-di-GMP) is a global signaling molecule that widely modulates diverse cellular processes. However, whether or not the c-di-GMP signal participates in regulation of bacterial antioxidant defense is unclear, and the involved regulators ...
Weihui Li, M. Li, Li-hua Hu, Jing-jing Zhu, Zhiwei Xie, Jiarui Chen, Zheng-Guo He   +6 more
semanticscholar   +1 more source

The First FRET-Based RNA Aptamer NanoKit for Sensitively and Specifically Detecting c‑di-GMP

An effective method to identify c-di-GMP may significantly facilitate the exploration of its signaling pathways and bacterial pathogenesis. Herein, we have developed the first conjugated polymer-amplified RNA aptamer NanoKit with a unique core–shell ...
Xinghai Ning (1372887), Yanyan Li (345271), Ya Gao (526722), Yuhang Liu (507131), Xiaotong Wu (5216231), Kerong Chen (4794003), Desheng Kong (40291), Yurui Xu (3777769), Xuli Feng (2405239)   +8 more
core   +1 more source

EphB1‐Mediated Transient Blood‐Brain Barrier Opening Facilitates a Ferritin‐Based Nanotherapeutic for Alzheimer's Disease

Advanced Science, EarlyView.
We constructed a brain‐targeted AFn‐DPZ nanodrug delivery system and identified EphB1 as its receptor on the blood‐brain barrier (BBB). This system facilitates drug transport across the BBB and thereby ameliorates cognitive impairment in Alzheimer's disease.
Shilin Wen, Jingjing Gao, Zhixian Wang, Qiumin Ma, Xiao‐Ling Xu, Jianer Chen   +5 more
wiley   +1 more source

EAEU Development and Production of Radiopharmaceuticals: Major Achievements, Growth Vectors, and Prospects

Регуляторные исследования и экспертиза лекарственных средств
A seven-year development plan of Russian pharmaceutical industry (Pharma 2030) includes all the tools that would allow Russia to implement technological self-sufficiency in pharmaceutical industry, in particular in development, research, and production ...
D. A. Rozhdestvensky
doaj   +1 more source

Genetic tools to study c-di-GMP-dependent signaling in Pseudomonas aeruginosa.

, 2017
Pseudomonas aeruginosa infections are often difficult or impossible to treat, mainly due to its ability to form antibiotic-resistant biofilms. Since c-di-GMP signaling strongly influences P.
Livia Leoni, Sarika Vishnu Pawar, Giordano Rampioni   +2 more
core   +1 more source

Microenvironment‐Responsive Nanomedicine Enables Vertical Modulation of Mitochondrial Pathological Networks in Myocardial Ischemia–Reperfusion Injury

Advanced Science, EarlyView.
A mitochondria‐targeted, microenvironment‐responsive nanoplatform enables pH/ROS‐triggered co‐delivery of berberine and isoliensinine to orchestrate ROS scavenging, inflammation suppression, and apoptosis inhibition. This vertical modulation of mitochondrial pathological networks preserves mitochondrial function and effectively mitigates myocardial ...
Jue Wang, Jia Zhou, Wenqin Yuan, Tianjiao Zhao, Yunying Huang, Yingci Xia, Yuting Lin, Fei Li, Qiong Huang, Chong Liu, Kelong Ai, Qun Qin   +11 more
wiley   +1 more source

Estudo da morte celular induzida por glutamato e sua modulação por guanosina-5'-monofosfato em fatias de hipocampo de ratos [PDF]

, 2003
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas. Programa de Pós-Graduação em Neurociências.O objetivo deste estudo foi avaliar o tipo de morte celular (apoptose ou necrose) induzida por glutamato em fatias ...
Molz, Simone
core  

Membrane‐Active Peptide Protects Against Inflammation by Targeting NLRP3 Activation at the Trans‐Golgi Network

Advanced Science, EarlyView.
The membrane‐active peptide Pep19‐2.5 reduces harmful inflammation by blocking activation of the NLRP3 inflammasome at trans‐Golgi network membranes. By targeting key membrane interactions, Pep19‐2.5 suppresses inflammatory IL‐1β production and alleviates allergic airway inflammation in mice, leading to reduced immune cell infiltration and improved ...
Jonas Engelhardt, Nico Kirsch, Aileen Kerfin, Lars P. Lunding, Dominic Ferber, Hannes Buthmann, Ilka Schreier, Carlotta Bosio, Ann‐Kathrin Dobbelstein, Anna Klawonn, Rebecca C. Coll, Lena Bauernhofer, Sandro Keller, Matthias Geyer, Michael Wegmann, Andra B. Schromm, Günther Weindl   +16 more
wiley   +1 more source

FUNGICIDE SENSITIVITY OF XYLARIA ISOLATES ASSOCIATED WITH ROOT AND BASAL STEM ROT OF SUGARCANE

Jurnal Agrotek Tropika
Root and basal stem rot is one of important diseases in sugarcane plantations in South Sumatra and Lampung. This disease is caused by Xylaria sp. The study is aimed to determine the fungicides sensitivity of Xylaria sp.
Rosa Indriani, Tri Maryono, Rusdi Evizal, Joko Prasetyo, Heru Pranata, Saefudin Saefudin   +5 more
doaj   +1 more source

VpsR and cyclic di-GMP together drive transcription initiation to activate biofilm formation in Vibrio cholerae

Nucleic Acids Research, 2018
The small molecule cyclic di-GMP (c-di-GMP) is known to affect bacterial gene expression in myriad ways. In Vibrio cholerae in vivo, the presence of c-di-GMP together with the response regulator VpsR results in transcription from PvpsL, a promoter of ...
M. Hsieh, D. Hinton, C. Waters
semanticscholar   +1 more source