Results 151 to 160 of about 117,081 (314)

High-Performance Multi-Precision Tool for Floating-Point Computations [PDF]

Radioengineering
This paper presents a MATLAB toolbox for multiple-precision arithmetic, enabling high-precision numerical computations beyond the standard double-precision format. The development step and functionality of the toolbox are described, and how it integrates
L. Leitold, M. Alrwashdeh, Z. Kollar
doaj  

The sRNA vvrr1 Modulates the VarS/VarA‐Csr System via LeuO to Regulate Biofilm Formation and Virulence in Vibrio alginolyticus

Animal Research and One Health, EarlyView.
vvrr1, a small RNA, post‐transcriptionally represses the transcriptional regulator LeuO, which directly inhibits the VarS/VarA two‐component system. This triggers a Csr cascade that relieves LuxO repression, ultimately modulating exopolysaccharide production to control biofilm formation and virulence in Vibrio alginolyticus.
Theerakamol Pengsakul, Lei Wen, Lingmin Zhao, Bei Huang, Jiang Zheng, Binfu Xu, Lixing Huang   +6 more
wiley   +1 more source

Visual and refractive evaluation of two diffractive trifocal intraocular lens platforms with distant and near dominant light energy distributions. [PDF]

Int J Ophthalmol
Son HS, Yu SH, Koh K, Auffarth GU, Łabuz G.   +4 more
europepmc   +1 more source

Regulatory harmonization: Evolution, globalization and future directions

British Journal of Clinical Pharmacology, EarlyView.
Regulatory harmonization has become an increasingly important and accepted approach to streamline regulatory review processes and expedite access to safe, effective and high‐quality medicines globally. This review explores the evolution and current status of regulatory harmonization, convergence and reliance initiatives.
Orin Chisholm, Elaine Y. L. Blair, Christine Y. Lu   +2 more
wiley   +1 more source

Operationalization of the African Medicines Agency: Retrospective evaluation of the continental centralized pilot procedure timelines to recommendation and national registrations

British Journal of Clinical Pharmacology, EarlyView.
Aims Regulatory inconsistency across Africa causes duplicative assessments, prolonged approvals, and delayed medical access. To inform the African Medicines Agency (AMA), the African Medicines Regulatory Harmonisation (AMRH) piloted Africa's first continental scientific evaluation of human medicinal products.
Alex Juma Ismail, Lerato Moeti, Delese Mimi Darko, Stuart Walker, Sam Salek   +4 more
wiley   +1 more source

Linking the second messenger cyclic di-GMP signaling with the regulatory activity of the small RNA ErsA in Pseudomonas aeruginosa. [PDF]

Nucleic Acids Res
Ferrara S, Brignoli T, Santoro S, Mastrangelo E, Bertoni G.   +4 more
europepmc   +1 more source

Safety and pharmacokinetics of inhaled aloxistatin: A first‐in‐human phase 1 dose escalation trial

British Journal of Clinical Pharmacology, EarlyView.
Aims Aloxistatin (E64d) is a membrane‐permeable cysteine protease inhibitor prodrug that is converted by esterases to the active metabolite E64c (loxistatin). This first‐in‐human study evaluated the safety, tolerability and pharmacokinetics of single ascending doses of inhaled E64d in healthy volunteers.
Sebastian Fähndrich, Franziska Friedrich, Daniel Soriano, Jona Gjeloshi, Björn C. Frye, Xuan Phuoc Nguyen, Lydia Herbstritt, Caroline von Spee‐Mayer, Britta Lang, Fabrice Nollevaux, Andreas Hoheisel, Dorothee Winterberg, Armin Braun, Thomas Epting, Christine Contini, Karl Winkler, Thomas Reinheckel, Franziska C. Trudzinski, Gernot Rohde, Daiana Stolz, Robert Bals, Martin J. Hug, Sebastian Wirtz, Christoph Peters, Carolin Jenkner   +24 more
wiley   +1 more source

Identification of Molecular Pathways Underlying Mn(II) Oxidation in Pseudomonas resinovorans. [PDF]

Environ Microbiol
Piazza A, Parra L, Gaffuri M, Malone JG, Ottado J, Gottig N.   +5 more
europepmc   +1 more source

GMP [PDF]

, 2019
openaire   +1 more source

Global Meeting Plus (GMP)

, 2007
Global Meeting Plus (GMP) is a Web-based collaborative GroupWare application, which consists of chat-channel, whiteboard, database, communication security, and pillow-talking.
Polina Galkin, Sanzheng Qiao, Dan Yan
core