Results 141 to 150 of about 157,757 (356)
, 2015 Tisztatéri terek anyag és személy forgalmát biztosító” GMP konform” zsilipezési rendszerrel kapcsolatos tervek elkészítése.gjVillamosmérnökBSc ...
Kovács, Péter
core
Cyclic GMP System in Epidermis: II. Histamine Stimulates Cyclic GMP Formation [PDF]
, 1979 In search of hormones and drugs which might elevate the intracellular level of cyclic GMP in pig epidermis, we have tested the effects of carbachol, concanavalin A, prostaglandin F2α, insulin, epinephrine, Vitamin A acid and histamine. Only histamine was
Adachi, Kenji +4 more
core +1 more source
Advanced Science, EarlyView.This study revealed that a PEAR1/HIF‐1α/ glycolysis/lactate/H3K18la positive feedback loop in PMVECs that drives the development of S‐ALI. Mechanistically, PEAR1 mediates the binding of HIF‐1α to AARS1, leading to the lactylation of HIF‐1α, the primary lactylation site of which is K172.
Shuai Li +15 more
wiley +1 more source
Advanced Science, EarlyView.Conceptual illustration of a Global Ecosystem Methane Observing System (GEM‐OS) integrating satellites, aircraft, atmospheric networks, and ecosystem measurements to quantify methane emissions from anthropogenic and natural sources. The multi‐scale observing framework improves source attribution, reduces uncertainty in regional methane budgets, and ...
P. Ciais +32 more
wiley +1 more source
Comparative analysis of integer factorization algorithms
MANAS: Journal of Engineering, 2015 Integer factorization problem, which is used as the basis in many public key cryptosystem, is generally thought to be hard problem even on a modern computers.
G. Kimsanova, R. Ismailova, R. Sultanov
doaj
Engineering‐Modulated Molybdenum Enzymes Strategy for Tumor‐Specific Metabolic‐Immunotherapy
Advanced Science, EarlyView.Biodegradable molybdenum sulfide nanoparticles were synthesized via a one‐pot strategy to increase molybdenum enzyme activity and thus effectively potentiate anti‐tumor immunity by integrating molybdenum‐based metalloimmunotherapy with hydrogen sulfide gas therapy.
Xiaoxiao Pan +14 more
wiley +1 more source
Good Manufacturing Practice (GMP) - Training
, 2023 Die Qualitätsanforderungen, die die (bio)-pharmazeutische Industrie an ihre Lieferanten stellt, sind im Allgemeinen hoch und werden von regulatorischer Seite strikt eingefordert. Lieferanten und Dienstleister müssen daher einen erheblichen Aufwand sowohl
Schröder, Christa (Prof. Dr.) +1 more
core +1 more source
AI Designed Conformation Locking Peptides Target STING to Restore Diabetic Wound Healing
Advanced Science, EarlyView.A generative AI pipeline identifies SCP‐1, a conformation‐locking peptide that stabilizes inactive STING. Incorporated into a dual‐responsive hydrogel for localized, MMP‐9‐triggered release, SCP‐1 suppresses inflammation, promotes reparative macrophage polarization, and accelerates diabetic wound healing.
Xinyu Li +8 more
wiley +1 more source
OVERVIEW OF GMP INSPECTIONS RESULTS OF FOREIGN MANUFACTURING SITES IN 2017
Разработка и регистрация лекарственных средств, 2019 The matter presents the analysis of results for GMP inspections of foreign manufacturing sites in 2017 and gives the comparison of them with the results from 2016. Statistical evaluation of the results obtained is also given.
V. A. Orlov
doaj
BCG HSP70 Reprograms Macrophages via Central Trained Immunity to Suppress Prostate Cancer
Advanced Science, EarlyView.BCG‐derived HSP70 (Dnak) safely induces central trained immunity via epigenetic, metabolic, and O‐GlcNAcylation reprogramming of bone marrow progenitors, driving tumor‐associated macrophages toward an M1‐like phenotype to suppress prostate cancer. ABSTRACT Trained immunity offers a promising yet clinically challenging strategy for cancer immunotherapy,
Peng Liu +12 more
wiley +1 more source