Results 141 to 150 of about 117,081 (314)

GMP Cytokines

We offer a large variety of GMP-grade cytokines. ActoFactor™ GMP cytokines are manufactured and tested in compliance with relevant GMP guidelines. ActoFactor™ GMP Cytokines combine quality and safety with regular production and quality control. Furthermore, these products are widely used in the field of cell therapy, pre-clinical research and drug ...
openaire   +2 more sources

Large Oncosomes Induce Pro‐Metastatic Stromal‐Myeloid Reprogramming

Advanced Science, EarlyView.
Large oncosomes systemically reprogram bone marrow mesenchymal stem cells through innate nucleic acid sensing, driving inflammatory and immunosuppressive remodeling that supports a metastasis‐permissive bone marrow environment, revealing a novel tumor‐host communication axis in cancer. ABSTRACT Bone metastasis can be facilitated by systemic remodeling,
Taylon Felipe Silva, Virginia Marcia Concato‐Lopes, Fatima Bedier, Lauren Newman, Diana Kitka, Jamelle Brown, Blandine Victor, Minhyung Kim, Tatyana Vagner, Catherine Grasso, Dmitriy Sheyn, Sungyong You, Michael R. Freeman, Fayyaz S. Sutterwala, Helen S. Goodridge, Caroline Jefferies, Paola de Candia, Jlenia Guarnerio, Dolores Di Vizio   +18 more
wiley   +1 more source

BRCA1 Mutation‐Recognizing Tetrahedral Framework Nucleic Acid Nanoplatform Enables Coordinated PARP/WEE1 Inhibition and STING‐Associated Antitumor Immunity in Ovarian Cancer

Advanced Science, EarlyView.
BRCA1 mutation‐responsive FBOA‐tFNA selectively recognizes mutant transcripts and coordinates reduction‐responsive intracellular delivery of olaparib and adavosertib, amplifying DNA damage and weakening G2/M checkpoint protection. These effects are accompanied by STING‐associated immune activation and stronger antitumor immunity, while sequential anti ...
Chenyi Wang, Mengying Yao, Jinhui Xie, Dingjie Wang, Yashi Shi, Xiaodan Mao, Chunhua Lu, Pengming Sun   +7 more
wiley   +1 more source

A Robust Deep Temporal Causal Discovery Platform for Single‐Cell Gene Regulatory Network Reconstruction

Advanced Intelligent Discovery, EarlyView.
scTIGER2.0 is a deep‐learning framework that infers gene regulatory networks from single‐cell RNA sequencing data. By integrating correlation, pseudotime ordering, deep learning and bootstrap‐based significance testing, it reduces false positives and reveals directional gene interactions.
Nishi Gupta, Madison Dautle, Shaoqiang Zhang, Yong Chen   +3 more
wiley   +1 more source

Engineering Intelligent iPSC Biomanufacturing: Integrating Robotic Automation, AI, and Process Control

Advanced Intelligent Systems, EarlyView.
This review highlights recent advances in automated iPSC culture systems integrating robotics, advanced imaging, artificial intelligence, and process control. These technologies improve reproducibility, scalability, and quality in cell expansion, differentiation, and real‐time monitoring, while emerging AI‐enabled and closed‐loop approaches offer new ...
Hyoryong Lee, Roma Desai, Byunggik Kim, Deok‐Ho Kim   +3 more
wiley   +1 more source

SOME ASPECTS OF CONDUCTING GMP INSPECTIONS IN RUSSIA

Сеченовский вестник, 2018
Development of pharmaceutical industry in Russia requires for a common approach to the qualification and standardization of manufacturing process for drug products.
G. N. Gildeeva, V. I. Yurkov
doaj  

Biomimetic Nanomedicine for Aging‐Impaired Bone Regeneration: From Microenvironmental Dysfunction to Precision Therapeutics

Advanced NanoBiomed Research, EarlyView.
Aging disrupts the cellular, immune, vascular, and neural processes required for bone regeneration. This review connects these pathological barriers with biomimetic nanomedicine design, highlighting strategies for cellular rejuvenation, immune modulation, vascular regeneration, and neuro–bone coupling.
Zeyu Wang, He Zhang, Simo Liu, Rui Wang, Yiran Wei, Kailu Zheng, Yanming Guo, Min Li, Dian Yuan, Yuxin Liu, Lifang Feng, Yongping Ma, Yan Liu   +12 more
wiley   +1 more source

Unraveling ovarian histology: The key morphological aspects that spur the development of the Fossa ovarii in equine

The Anatomical Record, EarlyView.
Abstract The equine ovary exhibits unique structural and developmental features that distinguish it from those of other domestic species, including the presence of an ovulation fossa and an inversion of cortical and medullary layers. This study aimed to investigate the morphostructural development of the equine fetal ovary, with particular emphasis on ...
Laura Ver Goltz, Silvio Pires Gomes, Bruno Cesar Schimming, Fabio Cesar Magioli Abdala, Maria Angélica Miglino, Tais Harumi de Castro Sasahara   +5 more
wiley   +1 more source

Comparative analysis of cytoarchitectonic and neurochemical aspects of the globus pallidus in the rock cavy (Kerodon rupestris) and the common marmoset (Callithrix jacchus)

The Anatomical Record, EarlyView.
Abstract The globus pallidus (GP), a subcortical structure within the basal ganglia, plays a crucial role in modulating cortico‐subcortical circuits related to motor control and associative/limbic functions. However, the cytoarchitectonic and neurochemical organization of this structure remains poorly characterized in naturally existing wild‐type ...
Lavínnya Yáskara de Aquino Matoso, Yasmin Pinto Fernandes Albuquerque, Karina Maia Paiva, Rodrigo Freire Oliveira, Nelyane Nayara Martins de Santana, Expedito Silva do Nascimento‐Júnior, Rovena Clara G. J. Engelberth, Jeferson de Souza Cavalcante, Adhil Bhagwandin, Paulo Leonardo Araújo de Góis Morais, José Rodolfo Lopes de Paiva Cavalcanti   +10 more
wiley   +1 more source

The Role of miRNAs in Chicken Immune Regulation and Prospects for Disease‐Resistant Breeding

Animal Research and One Health, EarlyView.
A schematic workflow illustrating the screening of disease‐resistant miRNAs and the generation of miRNA‐based disease‐resistant chickens via PGC‐mediated germline genome editing. ABSTRACT MicroRNAs (miRNAs) are emerging as pivotal regulators of the immune system, playing a decisive role in shaping disease resistance in chicken.
Qiangzhou Wang, Weiran Wu, Qingqing Cai, Jiaxing Wang, Qi Gao, Muhammad Iftikhar, Yulin Bi, Hao Bai, Lihong Gu, Guobin Chang, Shihao Chen   +10 more
wiley   +1 more source