Results 121 to 130 of about 157,757 (356)

Fatty Acid Binding Protein 5 Mediates Astrocytic Pyroptosis and Neuroinflammation in Epilepsy via cGAS/STING Pathway

Advanced Science, EarlyView.
Astrocytic FABP5 promotes mitochondrial stress, cGAS‐STING pathway activation, pyroptosis, and neuroinflammation in epilepsy, contributing to seizure pathology. Genetic targeting of FABP5 or pharmacological inhibition of STING alleviates epileptic phenotypes, highlighting a potential therapeutic strategy for epilepsy.
Chen Chen, Yao Zhao, Yangye Lian, Yifei Hou, Lifen Gong, Tingting Wu, Yulin Yang, Jiaqi Zhu, Xin Wang, Kaihua Zhang, Jing Ding   +10 more
wiley   +1 more source

O efeito trófico dos derivados da guanina em culturas de astrócitos e neurônios cerebelares [PDF]

, 2006
Dissertação (mestrado) - Universidade Federal de Santa Catarina. Centro de Ciências Biológicas. Programa de Pós-Graduação em Neurociências.Neste estudo foi avaliado o efeito de GMP ou Guanosina em três diferentes situações: o efeito trófico sobre ...
Decker, Helena
core  

Gene Correction Enhances Dopaminergic Cell Therapy in a Nonhuman Primate Model of Parkinson's Disease

Advanced Science, EarlyView.
LRRK2‐mutant induced pluripotent stem cells (iPSCs) were derived from a patient with Parkinson's disease (PD). Using CRISPR/Cas9–mediated gene editing, the pathogenic LRRK2 mutations were precisely corrected, and isogenic dopaminergic neural progenitor cells (DA‐NPCs) were subsequently generated.
Qing Yan, Chongchong Xu, Jiangmei Gao, Pu Wang, Qingling Wu, Ying Jin, Binyan Lu, Mu Li, Mingting Shao, Bihai Li, Zhenghui Su, Yijng Zhang, Jianhuan Chen, Haojie An, Mengyao Huang, Xiaoji Zhuang, Yuhui Shen, Fenglin Wang, Nana Xu, Yiyan Liu, Lei Tang, Xiuling Zhong, Minyan Zhong, Jiecong Chen, Zhenhuang Wang, Xingrong Luo, Sheng Liu, RuiFeng Liu, Ling Zhang, Junhua Rao   +29 more
wiley   +1 more source

Reduced Intracellular c-di-GMP Content Increases Expression of Quorum Sensing-Regulated Genes in Pseudomonas aeruginosa

Frontiers in Cellular and Infection Microbiology, 2017
Cyclic-di-GMP (c-di-GMP) is an intracellular secondary messenger which controls the biofilm life cycle in many bacterial species. High intracellular c-di-GMP content enhances biofilm formation via the reduction of motility and production of biofilm ...
Song Lin Chua, Yang Liu, Yingying Li, Hui Jun Ting, G. Kohli, Zhao Cai, Pipob Suwanchaikasem, Kelvin Kau Kit Goh, Sean Pin Ng, T. Tolker-Nielsen, Liang Yang, M. Givskov   +11 more
semanticscholar   +1 more source

Pseudomonas aeruginosa PAO1 preferentially grows as aggregates in liquid batch cultures and disperses upon starvation [PDF]

, 2009
In both natural and artificial environments, bacteria predominantly grow in biofilms, and bacteria often disperse from biofilms as freely suspended single-cells.
Klebensberger Janosch, Diane McDougald, Barraud, N, Kjelleberg Staffan, Rice Scott A., Webb, Jeremy S., Rice, Scott A., Kjelleberg, Staffan, Rice, SA, Ausubel, Frederick M., Nicolas Barraud, Klebensberger, J, Schleheck, D, Klebensberger, Janosch, David Schleheck, Schleheck, David, Kjelleberg, S, McDougald Diane, Staffan Kjelleberg, Barraud Nicolas, Webb Jeremy S., Jeremy S Webb, Barraud, Nicolas, Scott A Rice, Schleheck David, McDougald, Diane, McDougald, D, Webb, JS, Janosch Klebensberger   +28 more
core   +1 more source

Cerium Nanoparticle‐Mediated Inhibition of the NSUN2/m5C Axis Suppresses Synovial Aggression in Rheumatoid Arthritis

Advanced Science, EarlyView.
A novel epitranscriptomic mechanism in rheumatoid arthritis is uncovered: NSUN2 promotes disease via m5C‐dependent stabilization of ICMT mRNA, fueling the migration and invasion of pathogenic RA FLS. Targeting this axis with engineered nanoparticles (Ce/SAA NPs) effectively inhibits disease progression, presenting a precise therapeutic strategy ...
Ruiru Li, Simin Chen, Huijuan Hu, Shiyao Wu, Jingnan Wang, Kai Sun, Chenxi Peng, Suling Liu, Shuoyang Zhang, Yu Kuang, Wei Chen, Qian Qiu, Liuqin Liang, Yu Wen, Hanshi Xu, Youjun Xiao   +15 more
wiley   +1 more source

Fish commercialization in the main market places in Monteria, Colombia

Temas Agrarios, 2014
Fish commercialization in Colombia has increased in the last few years, due to benefits associated to its consumption. In Monteria city, most of the fish is sold in public market places, where currently the state of its commercialization is unknown.
Elvira Durán, Robinson R. Rosado, Oscar D. Ballesteros, David E. Lerma   +3 more
doaj   +1 more source

BrlR from Pseudomonas aeruginosa is a receptor for both cyclic di-GMP and pyocyanin

Nature Communications, 2018
The virulence factor pyocyanin and the intracellular second messenger cyclic diguanylate monophosphate (c-di-GMP) play key roles in regulating biofilm formation and multi-drug efflux pump expression in Pseudomonas aeruginosa.
Feng Wang, Qing He, Jia Yin, Sujuan Xu, Wei Hu, L. Gu   +5 more
semanticscholar   +1 more source

LRRC4 Orchestrates AP2A1‐Containing Clathrin‐Coated Vesicles to Disrupt Mitochondrial Cristae and Restrict Glioblastoma Progression

Advanced Science, EarlyView.
LRRC4 suppresses GBM by regulating AP2A1‐containing Golgi‐derived clathrin‐coated vesicles. Low LRRC4 allows cytoplasmic AP2A1 to maintain mitochondrial fission‐fusion, MICOS integrity, and OXPHOS, promoting proliferation and invasion. High LRRC4 redirects AP2A1‐containing Golgi‐derived clathrin‐coated vesicles to mitochondria, disrupts MICOS, enhances
Yang Li, Cheng Huang, Liangqi Jiang, Zhen Li, Qing Liu, Minghua Wu   +5 more
wiley   +1 more source

Processing Performance and Economic Feasibility Profile of Jambal Roti Salted Fish in Pangandaran, West Java

Grouper
Pangandaran's abundant fishery resources require proper processing to prevent rapid spoilage, making preservation through jambal roti salted fish production crucial for both food security and local livelihoods.
Ananda Dwi Septian, Iwang Gumilar, Nora Akbarsyah, Ine Maulina   +3 more
doaj   +1 more source