Results 171 to 180 of about 157,757 (356)

Fluorescent cAMP Analogs: Enzymatic Synthesis, Unexpected Photophysical Behavior and Protein Kinase A Recognition

open access: yesAngewandte Chemie, EarlyView.
Cyclic adenosine monophosphate (cAMP) is a key cellular second messenger. Adenylyl cyclase converts emissive isomorphic nucleoside triphosphates into fluorescent cAMPs. cthAMP displays unusually high brightness compared to thATP, its precursor, enabling real‐time monitoring of enzymatic reactions.
Deyuan Cong   +3 more
wiley   +2 more sources

Precision Oncology via Radiotherapy‐Triggered Drug Delivery: Mechanisms, Molecular Engineering, and Clinical Translation

open access: yesAdvanced Science, EarlyView.
This review redefines radiotherapy‐triggered drug delivery systems through structural disassembly and molecular actuation, proposing a translation‐oriented framework for dose‐correlated activation to advance clinically integrated precision oncology. ABSTRACT Radiotherapy‐triggered drug delivery systems (RDDS) promise to integrate the spatial precision ...
Jianv Jiang   +3 more
wiley   +1 more source

Cyclic di-GMP: the First 25 Years of a Universal Bacterial Second Messenger

open access: yesMicrobiology and Molecular Reviews, 2013
U. Römling   +2 more
semanticscholar   +1 more source

CAR‐Engineered Cell Therapies Beyond Cancer: Reprogramming Fibrosis and Immune‐Mediated Inflammation

open access: yesAdvanced Science, EarlyView.
CAR‐engineered cell therapies are expanding beyond cancer toward immune resetting, pathological‐cell clearance, matrix remodeling, and microenvironmental reprogramming in autoimmune, inflammatory, and fibrotic diseases. This Review compares CAR‐T, CAR‐macrophage, and CAR‐NK platforms and proposes controllable spatiotemporal reprogramming to align ...
Peng Jun Xu   +6 more
wiley   +1 more source

Comparative Analysis Of Integer Factorization Algorithms Using Cpu And Gpu

open access: yesMANAS: Journal of Engineering, 2017
In this work we have evaluated the running time of four integer factorization algorithms, namely, trial division algorithm, Fermat algorithm, Pollard rho and Brent algorithms.
Rita Ismailova   +2 more
doaj  

Non‐Invasively Quantitative Raman Imaging for Calculation of Lymphatic Transport Kinetics of Micelles in Mice

open access: yesAdvanced Science, EarlyView.
Non‐invasively quantitative Raman imaging with stacking‐induced charge transfer‐enhanced Raman scattering (SICTERS) enables accurate measurement of concentrations and pharmacokinetic modeling of lymphatic transport of micelles in mice. This platform allows dynamic analysis of nanoparticle transport and underpins the design of effective lymph node ...
Yunlu Li   +6 more
wiley   +1 more source

GMP Cytokines

open access: yes
We offer a large variety of GMP-grade cytokines. ActoFactor™ GMP cytokines are manufactured and tested in compliance with relevant GMP guidelines. ActoFactor™ GMP Cytokines combine quality and safety with regular production and quality control. Furthermore, these products are widely used in the field of cell therapy, pre-clinical research and drug ...
openaire   +2 more sources

A Robust Deep Temporal Causal Discovery Platform for Single‐Cell Gene Regulatory Network Reconstruction

open access: yesAdvanced Intelligent Discovery, EarlyView.
scTIGER2.0 is a deep‐learning framework that infers gene regulatory networks from single‐cell RNA sequencing data. By integrating correlation, pseudotime ordering, deep learning and bootstrap‐based significance testing, it reduces false positives and reveals directional gene interactions.
Nishi Gupta   +3 more
wiley   +1 more source

Rewriting Tumor Immunity With Bacterial Membrane Vesicles: A Versatile and Potent Therapeutic Strategy

open access: yesAdvanced NanoBiomed Research, EarlyView.
Bacterial membrane vesicles (BMVs) emerge as promising platforms for cancer immunotherapy owing to their intrinsic adjuvant properties and tunable cargo delivery capabilities. Their ability to modulate the tumor microenvironment, enhance antitumor immune responses, and support personalized therapeutic strategies highlights their growing potential as ...
Md Sifat Rahi   +6 more
wiley   +1 more source

Регламентація і документування системи управління якістю підприємства з виробництва лікарських засобів

open access: yes, 2015
Методичні рекомендації призначені для надання методичної допомоги виробникам ЛЗ щодо організації робіт з проектування, формування, впровадження та постійного удосконалення СУЯ згідно із вимогами GMP та ISO 9001.
Котвіцька, А. А.   +5 more
core  

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