Results 171 to 180 of about 117,081 (314)

Long-term stability of the GMP-compliant recombinant BCG vaccine against human RSV under quality control analyses. [PDF]

iScience
Troncoso-Bravo T, Rivera DB, Ramírez MA, Loaiza RA, Reyes A, Pavez V, Kourounis D, Tsatsara KP, Horefti E, Martinez-Gonzalez B, Rabias I, Peñaloza HF, González PA, Bueno SM, Kalergis AM.   +14 more
europepmc   +1 more source

10‐Fold Improvement in Depth Filter Capacity During Integrated Dynamic Bioprocessing (IDB) Purification Through Depth Filter Cycling and Precipitate Control Strategy

Biotechnology and Bioengineering, EarlyView.
ABSTRACT During bsAb1 purification, precipitate was formed during neutralization of the affinity capture product. This precipitate was removed before loading onto the first polishing column in the Integrated Dynamic Bioprocessing (IDB) platform.
David Scherr, Ana Kanazir, Samik Das, Nikunj Sharda, Jan Martinek, David Nellis, Michael Mollet, Jon Coffman   +7 more
wiley   +1 more source

A nutrient-sensing protease DegS suppresses biofilm formation in <i>Vibrio cholerae</i> via the CdgH-c-di-GMP-VpsR axis under nutrient limitation. [PDF]

Biofilm
Huang X, Chen T, Linghu Q, Wang H, Luo S, Zhou H, Min X, Huang J.   +7 more
europepmc   +1 more source

Binding of bacterial secondary messenger molecule c di-GMP is a STING operation

, 2013
Initial skirmishes between the host and pathogen result in spillage of the contents of the bacterial cell. Amongst the spillage, the secondary messenger molecule, cyclic dimeric guanosine monophosphate (c di-GMP), was recently shown to be bound by ...
Ouyang, Songying, Liu, Zhi-jie, Shaw, Neil, Liu, ZJ (reprint author), Chinese Acad Sci, Inst Psychol, Natl Lab Biomacromol, Beijing 100101, Peoples R China.   +3 more
core  

Mitochondria‐endoplasmic reticulum organelle glue as maturation promoter for origination/dimensional dual‐cross cardiomyocytes

BMEMat, EarlyView.
Mitochondria‐endoplasmic reticulum contact sites (MERCS) are areas where the mitochondria and endoplasmic reticulum closely interact. In this study, we utilize synthetic organelle glues to artificially engineer MERCS for regulating cardiomyocyte development, through which the immature and chemo‐plasticity issues of undifferentiated cells are addressed.
Wei Tang, Hao Sun, Chenqi Duan, Jiajia Chang, Yuxing Wang, Ming Zhao, Huiyue Zhao, Shan Lu, Yang Yang, Da Huo   +9 more
wiley   +1 more source

Safety, Feasibility, and Preliminary Efficacy of Allogeneic MSCs to Treat Advanced Femoral Head Osteonecrosis (ALOFEM): A Pilot Study in Young Onco-Hematological Patients

Stem Cells International
Enrique Gómez-Barrena, Norma G. Padilla-Eguiluz, Juan Cabello-Blanco, José Juan Pozo-Kreilinger, Yasmina Mozo-del-Castillo, María E. Martínez-Muñoz, Trinidad Martín-Donaire, Rocío Zafra, Rafael F. Duarte, Ana Velasco-Iglesias, Cristina Avendaño-Solà, Concepción Payares-Herrera   +11 more
doaj   +1 more source

A proposal of good manufacturing practices (GMP) laboratory for CAR T-cell therapy in Latin America and the Caribbean: challenges and opportunities. [PDF]

Front Public Health
Cabrera-Salcedo SC, Parra-Lara LG, Fernandes-Pineda M, Toro-Pedroza A, Hincapie JSV, Rios-Serna LJ, Loukanov A, Ortiz-Guzman J, Garcia-Robledo JE, Cañas CA, Cruz-Suarez GA, Osorio FO, Gustafson MP, Restrepo JG, Mosquera A, Hoyos V, Baena JC.   +16 more
europepmc   +1 more source

From pathogen to “living drug factory” innovative strategies and clinical translation of bacteria as programmable intelligent vectors for cancer therapy

BMEMat, EarlyView.
Engineered bacteria serve as smart, living therapeutics that target tumors, deliver drugs, and remodel immunosuppressive microenvironments. This review highlights their potential to potentiate immunotherapy, radiotherapy, and chemotherapy, offering a promising paradigm for precise and synergistic cancer treatment. Abstract The dynamic interplay between
Haonan Shen, Weichen Zhang, Gaoli Niu, Li Wang, Ruiyan Li, Yueyue Fan, Feixue Lu, Lingling Xu, Xiaoyuan Ji, Yong Kang   +9 more
wiley   +1 more source

The Italian Nanomedicine Platform (INP): national integration within the European nanomedicine ecosystem. [PDF]

Nanomedicine (Lond)
Tosi G, Rossi M, Calzà L, Valenza M, Quaglia F, Cavallaro G, Cauda V, Angeloni L, Bedoni M, Palumbo F, Pasut G.   +10 more
europepmc   +1 more source

Bridging the translational gap in clinical nanomedicine: From rational design to clinical reality

BMEMat, EarlyView.
Nanotechnology offers a multi‐faceted approach to modern healthcare, encompassing high‐sensitivity diagnostic imaging, innovative vaccine delivery, and targeted therapeutics. This review explores how these nanomedicine applications address critical challenges in cancer recurrence and the treatment of neurologic and respiratory diseases to combat rising
Ahmed H. Ghonaim, Marwa Ahmed El‐Naka, Wedad M. Nageeb, Atta Ullah Khan, Noura M. Seleem, Aliaa Abdelghafar, Doaa Zamel, Yang Liu, Qigai He, Wentao Li   +9 more
wiley   +1 more source