Results 191 to 200 of about 101,384 (314)

Radiolabeled Coordination Polymer‐Loaded Microneedles for Synergistic Melanoma Brachytherapy–Immunotherapy via STING Activation and Pyroptosis

Exploration, EarlyView.
We developed a dissolvable microneedle patch that locally delivers a radiolabeled coordination polymer designed to simultaneously destroy tumor cells and stimulate antitumor immunity through STING activation and pyroptosis. This strategy significantly inhibited melanoma growth and improved the effectiveness of immune checkpoint therapy, highlighting a ...
Pian Yu, Shijun Xiang, Lu Hao, Jessica C. Hsu, Kaixuan Li, Rongxuan Yan, Ming Zhou, Yongxiang Tang, Ying Peng, Weibo Cai, Cong Peng, Peng Liu, Shuo Hu   +12 more
wiley   +1 more source

A chemical bactericide dioctyldiethylenetriamine (Xinjunan) exerts a non-lethal effect by inhibiting RpfG activity to regulate the quorum sensing system. [PDF]

PLoS Pathog
Jin L, Chen X, Pang C, Huang Y, Ji C, Zhang Y, Liu X, Sun Y, Chen Y.   +8 more
europepmc   +1 more source

Smart Nanodelivery Systems for Immunometabolic Modulation in Osteoarthritis

Exploration, EarlyView.
Smart nanodelivery systems deliver therapeutic payloads across the cartilage matrix to ensure their sustained accumulation within chondrocytes at sites of injury. By targeting specific molecular targets and signaling pathways, these platforms modulate the pathological synovium‐cartilage axis to restore immunometabolic homeostasis and drive tissue ...
Qirui Zhao, Zhewen Mi, Shuya Liu, Shijun Liang, Linjia Peng, Zixuan Gao, Jiaming Li, Xiaoqing Lu, Zhiguang Ren, Yongjie Wan, Shengsheng Cui, Longlong Lu, Xiaoyang Gao, Tao Wang, Hui Liang, Furong Tian, de la Fuente Jesus M, Chong Xiang, Luyi Sun, Lichen Xiang, Daxiang Cui   +20 more
wiley   +1 more source

Structural analyses uncover protease-adhesin interactions and c-di-GMP receptor regulation in sulfate-reducing bacteria. [PDF]

Nat Commun
Font ME, Karbelkar AA, Lormand JD, Mortensen S, García-García MJ, O'Toole GA, Sondermann H.   +6 more
europepmc   +1 more source

Donkwa Enriched With Goron‐Tula (Azanza garckeana) Modulates Sexual Behavior and Activity of Enzymes Linked With Erectile Dysfunction in High‐Fat Diets/ Streptozotocin‐Induced (STZ/HFD) Diabetic Rats

Food Chemistry International, EarlyView.
(A) Mount number, (B) mount latency, (C) intromission number, and (D) intromission latency are the parameters of sexual behavior. Met = metformin. D100 = 100 Donkwa. D90G10 = 90% Donkwa + 10% Goron‐Tula. D85G15 = 85% Donkwa + 15% Goron‐Tula. D80G20 = 80% Donkwa + 20% Goron‐Tula. The mean ± standard error of the mean (SEM) expressed the results. *Values
O. T. Mamukuyomi, O. S. Ijarotimi, A. A. Badejo   +2 more
wiley   +1 more source

Network-level divergence in cyclic di-GMP signalling drives ecological versatility in Acinetobacter baumannii. [PDF]

NPJ Biofilms Microbiomes
de Dios R, Forsyth VS, Harkova LG, Schache KJ, Hsueh BY, Strat H, Riley B, Rubio A, Pérez-Pulido AJ, Waters CM, Mobley HLT, Crépin S, McCarthy RR.   +12 more
europepmc   +1 more source

Beyond Gut Modulation: A Critical Review of the Therapeutic Potential, Safety, and Clinical Prospects of Natural Polysaccharides for IBD

Food Safety and Health, EarlyView.
In this review, we critically summarized the application of natural polysaccharides (NPs) for the treatment of IBD. This approach combines, in a unique way (right), the basic structure–activity relationships of NPs from different origins (left) with their multipronged mode of action, which involves modulation of the gut microbiota and other ...
Felix Danso, A. M. Abd El‐Aty, Kwaku Amoah, Xianghong Ju   +3 more
wiley   +1 more source

A GMP-compliant formulation of regeneratively active polyphosphate for wound healing and skin regeneration.

Biomater Sci
Müller WEG, Neufurth M, La X, Nassabi H, Brösicke M, Dobmeyer R, Muñoz-Espí R, Wu C, Ushijima H, Schröder HC, Wang X.   +10 more
europepmc   +1 more source

A direct, real-time, spectrophotometric assay for measuring ENPP1-catalyzed cGAMP hydrolysis. [PDF]

J Biol Chem
Michalchik MM, Lombardo Z, Braddock DT, Cao W, De La Cruz EM.   +4 more
europepmc   +1 more source

Somatic cell reprogramming for Parkinson's disease treatment

Ibrain, Volume 11, Issue 1, Page 59-73, Spring 2025.
The fundamental purpose of cell reprogramming to treat Parkinson's disease is to generate dopaminergic neurons (DAN) and do transplantation. There are two ways to accomplish this. One method is to induce cells into induced DA neurons (iDAN) directly or to induce cells into induced pluripotent stem cells and ultimately into iDAN in vitro. Another option
Xiaozhuo Li, Kevin Fang, Fengping Wang
wiley   +1 more source