Results 201 to 210 of about 189,721 (306)

Plant Extracts Target Biofilms to Alleviate Nutritional and Metabolic Disorders in Animals. [PDF]

Vet Sci
Wang Y, Song S, Gao S, Zhang X, Wang Y, Liu B.   +5 more
europepmc   +1 more source

Multi‐Targeting Ligands as Prospective Therapeutics for Alzheimer's Disease, a Prevalent Neurodegenerative Disorder: Mechanistic Insights, Emerging Targets and Drug Discovery Campaigns

Medicinal Research Reviews, EarlyView.
ABSTRACT Alzheimer's disease (AD) is a debilitating neurodegenerative condition characterized by progressive cognitive impairment, memory deterioration, and neuronal dysfunction. Its complex pathophysiology involves multiple interlinked processes, including amyloid‐β (Aβ) aggregation, tau hyperphosphorylation, oxidative stress, neuroinflammation ...
Amandeep Thakur, Mandeep Rana, Sakshi Vanjani, Kei‐Chi Liou, Rajeev Taliyan, Kunal Nepali, Chih‐Hao Yang   +6 more
wiley   +1 more source

Adoption of international good manufacturing practices in the Nigerian pharmaceutical industry: promising results from a decade of investment. [PDF]

J Pharm Policy Pract
Adeyeye M, Ekwunife O, Esuga M, Njoku N, Boateng K, Ezeoke U, Monemeh F, Ekundayo O, Sambo A, Ogwuche E, Longe A, Ukwuru J, Nwokike J.   +12 more
europepmc   +1 more source

The Expanding Landscape of Microbiota Medicine: Indications, Therapeutic Modalities, and the Path Towards Integrative Microbiome‐Targeting Healthcare

Microbiota Medicine Research, EarlyView.
ABSTRACT The growing recognition of the microbiome's role in human health has propelled the emergence of microbiota medicine—a new discipline integrating microbiology, multi‐omics, and clinical science. Advances in sequencing, data integration, and interventions such as fecal microbiota transplantation (FMT) have transitioned the field from ...
Min Dai, Yisha Lin, Renyou Gan, Xiaotao Shen, Shin Young Park, Sunjae Lee, Qi Su   +6 more
wiley   +1 more source

Genetic diversification of <i>Pseudomonas fluorescens</i> maintained by multi-niche selection within biofilms. [PDF]

Appl Environ Microbiol
Matela AM, Siatkowski CW, Yan C, Thiagarajan S, Nawrocki EM, Cooper VS.   +5 more
europepmc   +1 more source

Depletion of microglial compensation in glial network: Disease‐associated response dynamics in the revised amyloid hypothesis

Neuroprotection, EarlyView.
The critical transition from amyloid pathology to irreversible neuronal loss in Alzheimer's disease hinges on the microglial response. This review aims to systematize the patterns of how microglia react within the glial context. Abstract Microglia mount coordinated, stage‐dependent compensatory programs in response to early amyloid β (Aβ) accumulation ...
Songtao Lei, Zixuan Huang, Wen Wang, Yan Meng   +3 more
wiley   +1 more source

Virulence Regulation and Lifestyle Transitions: The Role of c-di-GMP and Two-Component Systems in Erwinia amylovora and Their Evolutionary Context Within Enterobacterales. [PDF]

Mol Plant Pathol
Niroula D, Bhandari K, Sundin GW, Joshi JR.   +3 more
europepmc   +1 more source

Energy expenditure and cellular activity underlie antibiotic tolerance of <i>Pseudomonas aeruginosa</i>. [PDF]

mBio
Gates MF, Lewis K.
europepmc   +1 more source

Endoplasmic reticulum stress and the unfolded protein response in lung diseases: molecular pathways and therapeutic interventions

The Journal of Pathology, EarlyView.
Abstract Endoplasmic reticulum stress (ERS) occurs when the protein‐folding capacity of the endoplasmic reticulum (ER) is overwhelmed, triggering the unfolded protein response (UPR) to restore homeostasis. However, severe or persistent ERS can shift the UPR toward pro‐inflammatory, apoptotic, and fibrotic signaling, thereby exacerbating tissue injury ...
Lanlan Song, Yichen Liu, Chen Xu, Yaochen Zhang, Kaiming Xu, Dan Yao, Xiaoying Huang   +6 more
wiley   +1 more source

Distinct PlzC mechanisms integrate chemotaxis and c-di-GMP signaling to regulate <i>Vibrio cholerae</i> motility and biofilm formation. [PDF]

Proc Natl Acad Sci U S A
Park JH, Kennedy EN, Tripathi S, Romp AB, Rubin SM, Bourret RB, Yildiz FH.   +6 more
europepmc   +1 more source