Results 181 to 190 of about 157,757 (356)

SOME ASPECTS OF CONDUCTING GMP INSPECTIONS IN RUSSIA

Сеченовский вестник, 2018
Development of pharmaceutical industry in Russia requires for a common approach to the qualification and standardization of manufacturing process for drug products.
G. N. Gildeeva, V. I. Yurkov
doaj  

Unraveling ovarian histology: The key morphological aspects that spur the development of the Fossa ovarii in equine

The Anatomical Record, EarlyView.
Abstract The equine ovary exhibits unique structural and developmental features that distinguish it from those of other domestic species, including the presence of an ovulation fossa and an inversion of cortical and medullary layers. This study aimed to investigate the morphostructural development of the equine fetal ovary, with particular emphasis on ...
Laura Ver Goltz, Silvio Pires Gomes, Bruno Cesar Schimming, Fabio Cesar Magioli Abdala, Maria Angélica Miglino, Tais Harumi de Castro Sasahara   +5 more
wiley   +1 more source

Comparative analysis of cytoarchitectonic and neurochemical aspects of the globus pallidus in the rock cavy (Kerodon rupestris) and the common marmoset (Callithrix jacchus)

The Anatomical Record, EarlyView.
Abstract The globus pallidus (GP), a subcortical structure within the basal ganglia, plays a crucial role in modulating cortico‐subcortical circuits related to motor control and associative/limbic functions. However, the cytoarchitectonic and neurochemical organization of this structure remains poorly characterized in naturally existing wild‐type ...
Lavínnya Yáskara de Aquino Matoso, Yasmin Pinto Fernandes Albuquerque, Karina Maia Paiva, Rodrigo Freire Oliveira, Nelyane Nayara Martins de Santana, Expedito Silva do Nascimento‐Júnior, Rovena Clara G. J. Engelberth, Jeferson de Souza Cavalcante, Adhil Bhagwandin, Paulo Leonardo Araújo de Góis Morais, José Rodolfo Lopes de Paiva Cavalcanti   +10 more
wiley   +1 more source

High-Performance Multi-Precision Tool for Floating-Point Computations [PDF]

Radioengineering
This paper presents a MATLAB toolbox for multiple-precision arithmetic, enabling high-precision numerical computations beyond the standard double-precision format. The development step and functionality of the toolbox are described, and how it integrates
L. Leitold, M. Alrwashdeh, Z. Kollar
doaj  

Soft Law with Hard Consequences: The De Facto Binding Nature of Regulatory Notifications in Japanese Pharmaceutical Governance

Administrative notifications issued by the Japanese Ministry of Health, Labour and Welfare (MHLW) are formally classified as non-binding soft law.
Practitioner GMP
core   +1 more source

The Role of miRNAs in Chicken Immune Regulation and Prospects for Disease‐Resistant Breeding

Animal Research and One Health, EarlyView.
A schematic workflow illustrating the screening of disease‐resistant miRNAs and the generation of miRNA‐based disease‐resistant chickens via PGC‐mediated germline genome editing. ABSTRACT MicroRNAs (miRNAs) are emerging as pivotal regulators of the immune system, playing a decisive role in shaping disease resistance in chicken.
Qiangzhou Wang, Weiran Wu, Qingqing Cai, Jiaxing Wang, Qi Gao, Muhammad Iftikhar, Yulin Bi, Hao Bai, Lihong Gu, Guobin Chang, Shihao Chen   +10 more
wiley   +1 more source

Cyclic di-GMP directly reprograms the multidrug resistance machinery via UspG-mediated sequestration of RamR in Klebsiella. [PDF]

PLoS Pathog
Liu X, Wang M, Fu Y, Zhu X, Du M, Wen Y, Liao Y, Zhao Y, Deng Y, Gu B.   +9 more
europepmc   +1 more source

The sRNA vvrr1 Modulates the VarS/VarA‐Csr System via LeuO to Regulate Biofilm Formation and Virulence in Vibrio alginolyticus

Animal Research and One Health, EarlyView.
vvrr1, a small RNA, post‐transcriptionally represses the transcriptional regulator LeuO, which directly inhibits the VarS/VarA two‐component system. This triggers a Csr cascade that relieves LuxO repression, ultimately modulating exopolysaccharide production to control biofilm formation and virulence in Vibrio alginolyticus.
Theerakamol Pengsakul, Lei Wen, Lingmin Zhao, Bei Huang, Jiang Zheng, Binfu Xu, Lixing Huang   +6 more
wiley   +1 more source

A proposal of good manufacturing practices (GMP) laboratory for CAR T-cell therapy in Latin America and the Caribbean: challenges and opportunities. [PDF]

Front Public Health
Cabrera-Salcedo SC, Parra-Lara LG, Fernandes-Pineda M, Toro-Pedroza A, Hincapie JSV, Rios-Serna LJ, Loukanov A, Ortiz-Guzman J, Garcia-Robledo JE, Cañas CA, Cruz-Suarez GA, Osorio FO, Gustafson MP, Restrepo JG, Mosquera A, Hoyos V, Baena JC.   +16 more
europepmc   +1 more source

Regulatory harmonization: Evolution, globalization and future directions

British Journal of Clinical Pharmacology, EarlyView.
Regulatory harmonization has become an increasingly important and accepted approach to streamline regulatory review processes and expedite access to safe, effective and high‐quality medicines globally. This review explores the evolution and current status of regulatory harmonization, convergence and reliance initiatives.
Orin Chisholm, Elaine Y. L. Blair, Christine Y. Lu   +2 more
wiley   +1 more source