Results 111 to 120 of about 51,102 (238)
Aromatic emission from the ionised mane of the Horsehead nebula [PDF]
We study the evolution of the Aromatic Infrared Bands (AIBs) emitters across the illuminated edge of the Horsehead nebula and especially their survival and properties in the HII region.
Abergel, A. +7 more
core +2 more sources
Non‐Histone Lactylation: A New Frontier in Cerebral Ischemia‐Reperfusion Injury
ABSTRACT Reperfusion therapy is the mainstay of treatment for ischemic stroke (IS) but frequently exacerbates secondary injury. Following cerebral ischemia and hypoxia, lactate accumulates markedly. Traditionally regarded as a metabolic byproduct, lactate has gained new significance with the discovery of protein lactylation. In addition to experimental
Minghui Tang +13 more
wiley +1 more source
Ageing acts as a double‐edged sword in cancer. In the elderly, open chromatin, immunosenescence, and chronic inflammation drive SASP (IL‐6, MMPs), MDSC accumulation and T‐cell suppression, fostering tumor‐promoting microenvironments and limited therapeutic benefit.
Qi Wang +7 more
wiley +1 more source
Molecular Glue Degraders Redefining Targeted Therapies From Discovery to Therapeutic Applications
Molecular glue degraders (MGDs) constitute an emerging class of therapeutic agents poised to revolutionize the paradigm of targeted drug discovery. By reprogramming E3 ubiquitin ligases to degrade proteins of interest (POI) via a transient formation of a ternary complex mediated by protein–protein interactions, MGDs surpass the intrinsic limitations of
Jinfeng Wen +3 more
wiley +1 more source
Experience with the Jungfrau‐1M detector at Diamond Light Source
A Jungfrau‐1M integrating detector was characterized at Diamond Light Source and found to be effective for recording macromolecular crystallography diffraction patterns. Parameters for operation and data collection were explored and characterized. The Diamond facility will be upgraded and integrating detectors, such as Jungfrau, will be used more ...
John Matheson +20 more
wiley +1 more source
Optimal energy management of water networks under quality conditions
Abstract In the context of sustainability, which has become fundamental today, we aim to optimize (reduce) the energy consumption due to the use of pumps that bring water from all the different reservoirs to the nodes of the distribution network. The proposed model allows us, thanks to the use of smart meters and new 5G technologies, to determine the ...
Gabriella Colajanni +2 more
wiley +1 more source
Estimation of the Internal Temperature of High-Capacity Li-Ion Cells Using Embedded Impedancemetry
The internal temperature of electrochemical accumulators is a crucial parameter that significantly impacts their aging and safety. In particular, the phenomenon of thermal runaway must be detected early due to its rapid progression and potentially ...
Charles Bechara +3 more
doaj +1 more source
The "Solar Model Problem" Solved by the Abundance of Neon in Stars of the Local Cosmos
The interior structure of the Sun can be studied with great accuracy using observations of its oscillations, similar to seismology of the Earth. Precise agreement between helioseismological measurements and predictions of theoretical solar models has ...
CR Canizares +29 more
core +1 more source
Measurement of the Neutral Weak Form Factors of the Proton
We have measured the parity-violating electroweak asymmetry in the elastic scattering of polarized electrons from the proton. The kinematic point (theta_lab = 12.3 degrees and Q^2=0.48 (GeV/c)^2) is chosen to provide sensitivity, at a level that is of ...
Aniol, K. A. +3 more
core +1 more source
Dust processing in photodissociation regions - Mid-IR emission modelling
Mid-infrared spectroscopy of dense illuminated ridges (or photodissociation regions, PDRs) suggests dust evolution. Such evolution must be reflected in the gas physical properties through processes like photo-electric heating or H_2 formation.
A. Abergel +89 more
core +1 more source

