Results 101 to 110 of about 51,102 (238)

USP35 Acts as a Deubiquitinating Enzyme for ID3 to Promote Immune Escape in Colorectal Cancer

Advanced Science, Volume 13, Issue 16, 18 March 2026.
USP35 stabilizes ID3 expression by deubiquitinating the K2/K30 site, thereby upregulating PD‐L1 and promoting immune escape in colorectal cancer. IU1, an inhibitor of USP35 enzyme activity, has been shown to inhibit USP35, thereby accelerating ID3 degradation, enhancing CD8+ T cell killing, and reversing the immunosuppressive microenvironment ...
Wenxin Chen, Ling Wang, Hongmei Fan, Lisheng Li, Lingyu Zhang, Ruoxin Li, Fang Liu, Fuli Wen, Yunbin Ye, Chuanzhong Huang   +9 more
wiley   +1 more source

Analysis of excited quark propagator effects on neutron charge form factor

, 2019
The charge form factor and charge radius of neutron are investigated in the perturbative chiral quark model (PCQM) with considering both the ground and excited states in the quark propagator.
Khosonthongkee, K., Limphirat, A., Liu, X. Y., Samart, D., Xu, K., Yan, Y.   +5 more
core   +1 more source

Soft Photons in Hadron-Hadron Collisions: Synchrotron Radiation from the QCD Vacuum? [PDF]

, 1994
We discuss the production of soft photons in high energy hadron-hadron collisions. We present a model where quarks and antiquarks in the hadrons emit ``synchrotron light'' when being deflected by the chromomagnetic fields of the QCD vacuum, which we ...
A. Brandenburg, A. Messiah, A.D. Martin, A.I. Vainshtein, A.M. Rossi, A.T. Goshaw, B. Andersson, C.G. Callen Jr., E. Fermi, F. Borkowski, F. Botterweck, F.E. Low, G. Giacomelli, G. Mack, G. W. Botz, G.K. Savvidy, H. Leeb, H.G. Dosch, H.G. Dosch, H.G. Dosch, I. Abt, J. Ambjørn, J. Antos, J. Gasser, J.D. Bjorken, J.D. Jackson, J.D. Jackson, J.J. Aubert, L. Hove Van, M. Bourquin, M.A. Shifman, M.B. Voloshin, N.K. Nielsen, O. Nachtmann, O. Nachtmann, O. Nachtmann, O. Nachtmann, P. Haberl, P. Lichard, P. Lichard, P. Lichard, P.J. Sutton, P.V. Chliapnikow, P.V. Landshoff, Particle Data Group, R.P. Feynman, S. Abatzis, S. Banerjee, S. Platchkov, V. Černý, V.M. Budnev, V.N. Baier, W. Heitler, W.I. Smirnow   +53 more
core   +3 more sources

Analytic continuation of nucleon electromagnetic form factors in the time-like region

, 2015
The possibility to compute nucleon electromagnetic form factors in the time-like region by analytic continuation of their space-like expressions has been explored in the framework of the Skyrme model.
Alberto, Pedro, Drago, Alessandro, Mangoni, Alessio, Moretti, Simone, Pacetti, Simone   +4 more
core   +1 more source

Chromatin Accessibility in Cancer: Biological Functions, Mechanisms, Therapeutic Potential, and Future Directions

MedComm, Volume 7, Issue 3, March 2026.
Cancer remains the leading cause of mortality worldwide, and drug resistance further underscores the urgent need for innovative therapeutic strategies. Chromatin, a stable yet highly dynamic nucleoprotein complex, serves as the primary carrier of genetic material in eukaryotic cells.
Wentao Xia, Min Jiang, Yefei Huang, Kun Ding, Yansu Chen   +4 more
wiley   +1 more source

Novel GNE missense variants impair de novo sialylation and cause defective angiogenesis in the developing brain in mice

Blood Advances
Key Points • A pediatric patient presented with macrothrombocytopenia carrying 2 novel GNE missense variants (C594Y and P735R).• Mice with homozygous P735R mutations exhibited defective angiogenesis and cerebral hemorrhages as early as E11.
Lulu Huang, Yuji Kondo, Lijuan Cao, Jingjing Han, Tianyi Li, B. Zuo, Fei Yang, Yun Li, Zhenni Ma, Xia Bai, Miao Jiang, Changgeng Ruan, Lijun Xia   +12 more
semanticscholar   +1 more source

Protein Lactylation in Cancer: Mechanisms and Therapeutic Targets

MedComm, Volume 7, Issue 3, March 2026.
This schematic illustrates the central role of lactylation, a lactate‐derived posttranslational modification, in linking metabolic reprogramming to cancer progression and therapy resistance. At its core, lactylation modulates proteins, influenced by metabolic shifts and environmental factors.
Qianying Ouyang, Qianyu Hu, Caiqin Wang, Yizi He, Ruolan Zeng, Yajun Li, Chang Su, Guige Lu, Xueting Zhu, Ling Xiao, Hui Zhou   +10 more
wiley   +1 more source

Pregnancy in GNE myopathy patients: a nationwide repository survey in Japan

Orphanet Journal of Rare Diseases, 2020
Background GNE myopathy is an autosomal recessive adult-onset distal myopathy. While a few case reports have described the progression of GNE myopathy during pregnancy, to our knowledge, none have examined disease progression after delivery or obstetric ...
Wakako Yoshioka, Naoyuki Miyasaka, Ryo Okubo, Reiko Shimizu, Yuji Takahashi, Yuriko Oda, Ichizo Nishino, Harumasa Nakamura, Madoka Mori-Yoshimura   +8 more
doaj   +1 more source

GNE Myopathy: Genotype – Phenotype Correlation and Disease Progression in an Indian Cohort

Journal of Neuromuscular Diseases
Introduction: GNE myopathy is a rare slowly progressive adult-onset distal myopathy with autosomal recessive inheritance. It has distinctive features of quadriceps sparing with preferential anterior tibial involvement.
Dipti Baskar, Nishanth Reddy, V. Preethish-Kumar, K. Polavarapu, Vikas Nishadham, S. Vengalil, S. Nashi, S. B. Sanka, Mainak Bardhan, Akshata Huddar, G. Unnikrishnan, G. Harikrishna, S. Gunasekaran, Priya Treesa Thomas, M. Keerthipriya, M. Girija, G. Arunachal, R. Anjanappa, Ichizo Nishino, O. Pogoryelova, H. Lochmuller, A. Nalini   +21 more
semanticscholar   +1 more source

Proton and neutron electromagnetic form factors and uncertainties

, 2017
We determine the nucleon electromagnetic form factors and their uncertainties from world electron scattering data. The analysis incorporates two-photon exchange corrections, constraints on the low-Q2 and high-Q2 behavior, and additional uncertainties to ...
Arrington, John, Hill, Richard J., Lee, Gabriel, Ye, Zhihong   +3 more
core   +3 more sources