Results 81 to 90 of about 6,315 (194)

Evolution of Endoscopic and Histologic Assessment of Eosinophilic Esophagitis in Europe and Evolution of the Diagnostic Delay: Data From the EUREOS EoE CONNECT Registry

United European Gastroenterology Journal, Volume 14, Issue 7, September 2026.
ABSTRACT Background Endoscopy with histopathological assessment of esophageal biopsies is the cornerstone for the diagnosis and phenotypic characterization of eosinophilic esophagitis (EoE). Objective To evaluate temporal trends in endoscopic assessment and biopsy sampling practices for EoE in a large European cohort and their association with temporal
E. Grueso‐Navarro, E. Dilaghi, J. Fernández‐Pacheco, E. Amorena, E. V. Savarino, L. Blas‐Jhon, I. Pérez‐Martínez, A. Granja‐Navacerrada, D. Guagnozzi, L. Martín‐Asenjo, G. Pellegatta, M. Coletta, C. García‐Suárez, S. de la Riva, L. de la Peña‐Negro, E. Betoré, A. L. Krarup, J. Barrio, M. Votto, L. Bujanda, S. Fernández‐Fernández, J. E. Naves, A. González‐Almeida, R. Honrubia‐López, S. Carrión, S. Oliva, C. Caño‐Cerdán, M. L. Masiques‐Mas, S. Espina‐Cadena, J. González‐Cervera, S. Casabona‐Francés, J. Nicolay‐Maneru, V. Úbeda‐Vargas, M. Ghisa, P. Romo‐de Arriba, C. Donado, A. Benagues, V. Martín‐Domínguez, O. Nantes‐Castillejo, L. Arias‐González, D. Maniero, H. Moreira‐González, I. Maray, J. Barrio‐Torres, M. T. Pérez‐Fernández, M. Ostiz‐Llanos, L. Rodríguez‐Alcolado, A. M. Cabrera‐Martínez, E. J. Laserna‐Mendieta, C. Santander, A. J. Lucendo   +50 more
wiley   +1 more source

Identification of biomarkers for GNE myopathy

The FASEB Journal, 2012
GNE‐myopathy is an autosomal recessive disorder characterized by muscle atrophy and weakness, and accumulation of amyloid proteins and rimmed vacuoles in myofibers. This disease is secondary to mutations in the GNE gene, which encodes an essential enzyme in sialic acid biosynthesis. Recently,
May Christine Malicdan, Kazunari Momma, Ichizo Nishino, Satoru Noguchi   +3 more
openaire   +1 more source

GNE myopathy with premature ovarian failure: Case report and review of the literature

Molecular Genetics and Metabolism Reports
GNE myopathy (GNE-M) is an ultra-rare disease characterized by muscle weakness in the extremities. The main etiology is that a pathogenic variation in the GNE gene leads to a reduction in sialic acid synthesis.
Shangyi Yang, Jine Yang
doaj   +1 more source

Product heterogeneity, price index bias, and their link to provincial urban size: Evidence from urban China's beverage market

Canadian Journal of Agricultural Economics/Revue canadienne d'agroeconomie, Volume 74, Issue 3, Page 196-226, September 2026.
Abstract Conventional price indexes partially address product heterogeneity. This paper considers the variety and quality of products in each market, the combination of region and year, and constructs panel price indexes using household scanner data on non‐alcoholic beverages in urban China.
Soye Shin
wiley   +1 more source

Prmt6 Deficiency Drives Osteoblast Senescence Promoting Age‐Related Osteoporosis via Epigenetic Remodelling of the H3R2me2a/Sting/Ifitm3 Pathway

Journal of Cellular and Molecular Medicine, Volume 30, Issue 18, September 2026.
ABSTRACT Protein arginine methyltransferase 6 (Prmt6), an epigenetic regulator, plays an unclear role in bone homeostasis and osteoblast senescence. In this study, we employed Western blot, qPCR, immunofluorescence, SA‐β‐Gal staining, and RNA‐seq to systematically investigate the regulatory mechanism of the Prmt6/H3R2me2a/Sting/Ifitm3 axis in ...
Yuxue Wang, Xiaoyong Ge, Shengjie Chang, Diankai Wang, Ke Xu, Haowei Xu, Xiaowei Liu, Shanjin Wang   +7 more
wiley   +1 more source

DataSheet1_Generation and characterization of a novel gne Knockout Model in Zebrafish.docx

, 2022
GNE Myopathy is a rare, recessively inherited neuromuscular worldwide disorder, caused by a spectrum of bi-allelic mutations in the human GNE gene. GNE encodes a bi-functional enzyme responsible for the rate-limiting step of sialic acid biosynthesis ...
Tom Avital (13999905), Stella Mitrani-Rosenbaum (216109), Hagay Livne (13999902), Shmuel Ruppo (13999908), Avi Harazi (13999911), Alon Daya (13999914)   +5 more
core   +1 more source

Synthesis of Ethyl Methyl Carbonate: Past, Present, and Future

Advanced Synthesis &Catalysis, Volume 368, Issue 15, 1 August 2026.
Ethyl methyl carbonate (EMC) is the simplest asymmetric organic carbonate, with properties between dimethyl (DMC) and diethyl (DEC) carbonate, considered a unique green liquid organic compound for lithium batteries (electrolyte) and gasoline blending (octane enhancer additive), among other uses. In accordance, the chemical production of EMC is expected
Belén Lerma‐Berlanga, Antonio Leyva‐Pérez   +1 more
wiley   +1 more source

Antibody–Drug Conjugates and Peptide–Drug Conjugates: Current Understandings and Future Perspectives

MedComm, Volume 7, Issue 8, August 2026.
The graphic summarizes the design principles, intracellular trafficking, clinical progress, challenges, and future directions of antibody–drug conjugates (ADCs) and peptide–drug conjugates (PDCs). ADCs consist of a tumor‐targeting antibody, a chemical linker, and a potent payload, whereas PDCs use peptide ligands to deliver cytotoxic, radionuclide, or ...
Ruxi Zheng, Shuiquan Li, Zhigang Zhang, Mengke Niu, Jing Fei, Jiaojiao Zhang, Jianwei Zhou, Kongming Wu, Ming Yi, Tianye Li   +9 more
wiley   +1 more source

The BET PROTAC inhibitor GNE-987 displays anti-tumor effects by targeting super-enhancers regulated gene in osteosarcoma

BMC Cancer
Background Osteosarcoma (OS) is one of the most common primary malignant tumors of bone in children, which develops from osteoblasts and typically occurs during the rapid growth phase of the bone.
Di Wu, Hongli Yin, Chun Yang, Zimu Zhang, Fang Fang, Jianwei Wang, Xiaolu Li, Yi Xie, Xiaohan Hu, Ran Zhuo, Yanling Chen, Juanjuan Yu, Tiandan Li, Gen Li, Jian Pan   +14 more
doaj   +1 more source

Estimation of the Internal Temperature of High-Capacity Li-Ion Cells Using Embedded Impedancemetry

IEEE Open Journal of Vehicular Technology
The internal temperature of electrochemical accumulators is a crucial parameter that significantly impacts their aging and safety. In particular, the phenomenon of thermal runaway must be detected early due to its rapid progression and potentially ...
Charles Bechara, Guy Friedrich, Christophe Forgez, Samuel Cregut   +3 more
doaj   +1 more source