Results 81 to 90 of about 5,472 (195)
The FEBS Journal, Volume 293, Issue 8, Page 2159-2177, April 2026.Genetic rearrangements resulting in the expression of KMT2A fusion alleles can lead to dramatic transcriptional disturbances that contribute to the onset of acute leukaemias. Fortunately, menin inhibition has emerged as a promising new class of targeted therapy.
Lydia Elaine Roets +2 more
wiley +1 more source
Native Mass Spectrometry for the Study of PROTAC GNE‐987‐Containing Ternary Complexes
, 2021 PRO teolysis TA rgeting C himeras (PROTACs) promote the degradation, rather than inhibition, of a drug target as a mechanism for therapeutic treatment.
Miaomiao Liu +9 more
core +1 more source
GlycoChat Uncovers Glycan–Lectin Circuits in the Tumor Microenvironment of Pancreatic Cancer
Advanced Science, Volume 13, Issue 14, 9 March 2026.Aberrant glycosylation drives cancer progression, yet its role in the tumor microenvironment remains unclear. We developed GlycoChat to map glycan–lectin circuits at single‐cell resolution. We discovered that cancer cells induce immunosuppressive macrophage differentiation and impair phagocytosis through interactions with CLEC10A and SIGLEC3 ...
Dinh Xuan Tuan Anh +8 more
wiley +1 more source
Pregnancy in GNE myopathy patients: a nationwide repository survey in Japan
Orphanet Journal of Rare Diseases, 2020 Background GNE myopathy is an autosomal recessive adult-onset distal myopathy. While a few case reports have described the progression of GNE myopathy during pregnancy, to our knowledge, none have examined disease progression after delivery or obstetric ...
Wakako Yoshioka +8 more
doaj +1 more source
USP35 Acts as a Deubiquitinating Enzyme for ID3 to Promote Immune Escape in Colorectal Cancer
Advanced Science, Volume 13, Issue 16, 18 March 2026.USP35 stabilizes ID3 expression by deubiquitinating the K2/K30 site, thereby upregulating PD‐L1 and promoting immune escape in colorectal cancer. IU1, an inhibitor of USP35 enzyme activity, has been shown to inhibit USP35, thereby accelerating ID3 degradation, enhancing CD8+ T cell killing, and reversing the immunosuppressive microenvironment ...
Wenxin Chen +9 more
wiley +1 more source
Identification of biomarkers for GNE myopathy
The FASEB Journal, 2012 GNE‐myopathy is an autosomal recessive disorder characterized by muscle atrophy and weakness, and accumulation of amyloid proteins and rimmed vacuoles in myofibers. This disease is secondary to mutations in the GNE gene, which encodes an essential enzyme in sialic acid biosynthesis. Recently,
May Christine Malicdan +3 more
openaire +1 more source
MedComm, Volume 7, Issue 3, March 2026.Cancer remains the leading cause of mortality worldwide, and drug resistance further underscores the urgent need for innovative therapeutic strategies. Chromatin, a stable yet highly dynamic nucleoprotein complex, serves as the primary carrier of genetic material in eukaryotic cells.
Wentao Xia +4 more
wiley +1 more source
GNEM712T muscles display changes to GM3 levels.
, 2013 GneM712T/M712T (grey) mouse muscle experienced reduced levels of GM3 gangliosides compared with Gne+/+ (white) muscle. HPLC data from a minimum of five replicates are pooled for the Gne+/+ and GneM712T/M712T samples (*, p = 0.008751, Student t test).
Zoé Coulombe (365862) +2 more
core +1 more source
BMC CancerBackground Osteosarcoma (OS) is one of the most common primary malignant tumors of bone in children, which develops from osteoblasts and typically occurs during the rapid growth phase of the bone.
Di Wu +14 more
doaj +1 more source
Estimation of the Internal Temperature of High-Capacity Li-Ion Cells Using Embedded Impedancemetry
IEEE Open Journal of Vehicular TechnologyThe internal temperature of electrochemical accumulators is a crucial parameter that significantly impacts their aging and safety. In particular, the phenomenon of thermal runaway must be detected early due to its rapid progression and potentially ...
Charles Bechara +3 more
doaj +1 more source