Results 61 to 70 of about 4,046 (167)

Lysine l‐Lactylation: Bridging Metabolism, Chromatin and Disease

Cell Proliferation, Volume 59, Issue 8, August 2026.
Enzymatic regulation of KL‐la. The enzymatic regulation of KL‐la involves two distinct pathways for L‐lactate accumulation: intracellular production through glycolysis‐derived pyruvate conversion by lactate dehydrogenase (LDH) or direct cellular uptake via monocarboxylate transporters (MCTs). These L‐lactate pools fuel two distinct lactylation pathways—
Anoosha Malik, Muhammad Dilawar, Junguang Liao, Jie Zheng, Qitao Qian, Ming Xu, Sisi Lin, Xiaobo Zhu, Qiuwei Ge, Limin Jin, Guiqian Chen   +10 more
wiley   +1 more source

Long-term inhibition of mutant LRRK2 hyper-kinase activity reduced mouse brain α-synuclein oligomers without adverse effects

npj Parkinson's Disease, 2022
Parkinson’s disease (PD) is characterized by dopaminergic neurodegeneration in nigrostriatal and cortical brain regions associated with pathogenic α-synuclein (αSyn) aggregate/oligomer accumulation.
Philip Wing-Lok Ho, Eunice Eun-Seo Chang, Chi-Ting Leung, Huifang Liu, Yasine Malki, Shirley Yin-Yu Pang, Zoe Yuen-Kiu Choi, Yingmin Liang, Weng Seng Lai, Yuefei Ruan, Kenneth Mei-Yee Leung, Susan Yung, Judith Choi-Wo Mak, Michelle Hiu-Wai Kung, David B. Ramsden, Shu-Leong Ho   +15 more
doaj   +1 more source

Along the Benthic to Holoplanktonic Continuum: Seafloor Affinity Increases Distance‐Decay Rates Among Abyssal Communities

Global Ecology and Biogeography, Volume 35, Issue 8, August 2026.
ABSTRACT Aim Marine species ranges are often large, contributing to relatively high community similarity over space, with decreased ranges expected among taxa that have lower dispersal and/or higher substrate requirements. We tested for a weakening of biogeographic structuring among dispersing abyssal taxa along the benthic to holoplanktonic habitat ...
Gabrielle N. Ellis, Oliver Kersten, Eric Vetter, Craig R. Smith, Jeffrey C. Drazen, Erica Goetze   +5 more
wiley   +1 more source

COMPASS: A Computational Pipeline to Identify Linkers Predicting Ubiquitinable PROTAC‐Induced Ternary Complexes

ChemMedChem, Volume 21, Issue 14, 29 July 2026.
COMPASS enables structure‐based screening of PROTAC linker libraries by jointly evaluating ternary complex formation and ubiquitination competence. The pipeline accurately recovers experimentally observed ternary complex geometries and identifies linkers unlikely to support productive degradation. By eliminating unproductive candidates before synthesis,
Sébastien Sueron, Sayyed Jalil Mahdizadeh, Eric Chevet, Xavier Guillory, François‐Hugues Porée, Leif A. Eriksson   +5 more
wiley   +1 more source

4472 Plasma Neurofilament Light as a Biomarker for Pediatric Patients with Huntington’s Disease

Journal of Clinical and Translational Science, 2020
OBJECTIVES/GOALS: The goal of this study is to compare plasma neurofilament light (NfL) concentrations in asymptomatic children and young adults that carry the gene expansion (GE group) that causes Huntington’s Disease to similar subjects that do not ...
Jordan L Schultz
doaj   +1 more source

Eyes Toward the Clinic: Selective Inhibition and Degradation Approaches to Bromodomain‐Containing Proteins

ChemBioChem, Volume 27, Issue 13, 14 July 2026.
The function of bromodomain‐containing proteins in regulating gene transcription is reviewed here, including the development of chemical probes and targeted protein degradation modalities (e.g., PROTACs). This extends to clinical efforts targeting the BET bromodomain‐containing proteins. Challenges of selectivity, future prospects, and the differential
Cole R. Scholtz, William C. K. Pomerantz
wiley   +1 more source

DNA methylation abnormalities induced by advanced maternal age in villi prime a high-risk state for spontaneous abortion

Clinical Epigenetics, 2023
Background Advanced maternal age (AMA) has increased in many high-income countries in recent decades. AMA is generally associated with a higher risk of various pregnancy complications, and the underlying molecular mechanisms are largely unknown.
Meng Qin, Wei Chen, Lingyue Hua, Yan Meng, Jing Wang, Hanna Li, Rui Yang, Liying Yan, Jie Qiao   +8 more
doaj   +1 more source

Targeting Supramolecular Active Complexes of Nav1.7/Nav1.8 to Relieve Chronic Neuropathic Pain

Advanced Science, Volume 13, Issue 41, 22 July 2026.
In mice and patients with severe chronic neuropathic pain (NP), Nav1.7, Nav1.8, TrkB, and five cytoskeletal proteins form supramolecular active complexes (SMACs) with polygonal lattice structures as noxious signal amplifiers in dorsal root ganglion (DRG) neurons.
Liting Sun, Hang Xian, Yunxin Shi, Taotan Yang, Hongyan Shuai, Wenchao Hu, Siying Fei, Miao Xu, Taoyuan Yang, Ruilong Xia, Ting Wen, Fengting Zhu, Yan Fu, Yang Li, Wei Xia, Ran Qian, Yuanying Liu, Zhicheng Tian, Lamei Li, Qian Zhou, Lize Xiong, Rui Cong, Ceng Luo, Shengxi Wu, Xiafeng Shen, Xin Yu, Rou‐Gang Xie, Changgeng Peng   +27 more
wiley   +1 more source

Novel GNE mutations in three Chinese patients with typical GNE myo-pathy.

JPMA. The Journal of the Pakistan Medical Association, 2021
GNE myopathy is an adult-onset muscle disorder featuring distal muscle atrophy and weakness. Rimmed vacuoles found in the muscle biopsies and gene mutations lead to the diagnosis of GNE myopathy. We collected clinical information, performed muscle biopsies and genetic testing on three patients.
Rui, Ban, Xianghui, Lu, Chuanqiang, Pu, Huifang, Wang, Huaxu, Liu, Yutong, Zhang, Qiang, Shi   +6 more
openaire   +1 more source

Supply Chain Diversification and Industrial Policies to Strengthen Economic Security

Asian Economic Policy Review, Volume 21, Issue 2, Page 147-160, July 2026.
ABSTRACT Recently, global supply chains have been disrupted because of geopolitical factors and industrial policies induced by national security concerns. Under these circumstances, creating supply chain resilience and strengthening economic security are of great interest to researchers, policymakers, and business people.
Yasuyuki Todo
wiley   +1 more source