Results 51 to 60 of about 6,315 (194)
Loss of GNE Predicts Lymph Node Metastasis in Early Gastric Cancer
Cells, 2022 Endoscopic surgery is increasingly utilized for the treatment of early gastric cancer (EGC) worldwide, whereas lymph node metastasis (LNM) remains a critical risk factor for the relapse of EGC after endoscopic surgery.
Xinying Guo +8 more
doaj +1 more source
GNE-617 reduces NAD levels in sensitive and resistant cell lines.
, 2016 A) Structure of GNE-617 with its biochemical IC50 for NAMPT. B) Correlation between NAMPT protein levels and sensitivity to GNE-617 (IC50) determined in a 4-day viability assay.
Anneleen Daemen (365394) +6 more
core +1 more source
Autophagy in GNE Myopathy [PDF]
, 2013 Muscle diseases represent specific muscle pathology. The characteristic features as hallmarks of diseases have been historically used to diagnose the patients. The “Rimmed vacuole (RV)” (Figures 1) is one of such characteristic features in certain groups of the diseases.
Anna Cho, Satoru Noguchi
openaire +1 more source
Myogenesis defects in a patient-derived iPSC model of hereditary GNE myopathy
npj Regenerative Medicine, 2022 Hereditary muscle diseases are disabling disorders lacking effective treatments. UDP-N-acetylglucosamine-2-epimerase/N-acetylmannosamine kinase (GNE) myopathy (GNEM) is an autosomal recessive distal myopathy with rimmed vacuoles typically manifesting in ...
Rebecca E. Schmitt +8 more
doaj +1 more source
The Anatomical Record, EarlyView.Abstract Extant turtles occupy freshwater, marine, and terrestrial habitats, and their nasal region provides important evidence for the evolution of respiration‐ and sensory‐related cranial morphology. However, developmental data on the turtle nasal capsule remain limited, particularly in Pleurodira.
Kai Ito +5 more
wiley +1 more source
, 2018 The biological functions of the dual bromodomains of human transcription-initiation-factor TFIID subunit 1 (TAF1(1,2)) remain unknown, although TAF1 has been identified as a potential target for oncology research.
Vickie Tsui (1947505) +29 more
core +2 more sources
Journal of Organizational Behavior, EarlyView.ABSTRACT The non‐rationalist view of morality holds that all employees—including “good” apples—are liable to do bad because they are susceptible to moral biases in everyday situational encounters. In contrast, the rationalist or trait view suggests that employees with strong moral character should be resilient against moral biases across situations and
Babatunde Ogunfowora +3 more
wiley +1 more source
Assessment of Lectin Staining Biomarkers for GNE Myopathy Gene Therapy
Muscle &Nerve, EarlyView.ABSTRACT Introduction/Aims GNE myopathy (GNEM) is a rare, autosomal recessive disorder caused by mutations in the UDP‐N‐acetylglucosamine (GlcNAc) 2‐epimerase/N‐acetylmannosamine (ManNAc) kinase (GNE) gene, which encodes a required enzyme for sialic acid (SA) biosynthesis.
Kristina M. Sattler +8 more
wiley +1 more source
The Prostate, EarlyView.ABSTRACT Background For prostate cancer (PCa), early diagnosis and biomarker‐based patient stratification can improve clinical decision‐making and post‐treatment prognosis. PCa biomarkers are best validated in tissue following comprehensive histopathologic review; however, urinary biomarkers can be obtained non‐invasively and are therefore safer and ...
Yuandong Xing +11 more
wiley +1 more source
Gene Editing for Haemophilia—The Next Frontier
Haemophilia, EarlyView.ABSTRACT The recently approved haemophilia A and B gene therapies via adeno‐associated virus (AAV) showed a promising therapeutic response after a single injection, but there are still limitations, including the potential loss of transgene expression and restriction in adults.
Mirko Pinotti +3 more
wiley +1 more source