Results 71 to 80 of about 4,046 (167)

Antibacterial Activity of Heteropolytungstates Against Proteus mirabilis

open access: yesEuropean Journal of Inorganic Chemistry, Volume 29, Issue 18, 22 June 2026.
We investigated the in vitro antibacterial activity of several heteropolytungstates against P. mirabilis, a drug‐resistant pathogen. All tested polyanions inhibited bacterial growth, with the Preyssler–Pope–Jeannin polyanion P5W30 exhibiting the highest activity (MIC = 0.78 mg/mL).
Nour El Ghouch   +5 more
wiley   +1 more source

Pregnancy in GNE myopathy patients: a nationwide repository survey in Japan

open access: yesOrphanet Journal of Rare Diseases, 2020
Background GNE myopathy is an autosomal recessive adult-onset distal myopathy. While a few case reports have described the progression of GNE myopathy during pregnancy, to our knowledge, none have examined disease progression after delivery or obstetric ...
Wakako Yoshioka   +8 more
doaj   +1 more source

Lactate metabolism and lactylation in female reproductive diseases: From metabolic rewiring to biomarkers and translational therapeutics

open access: yesClinical and Translational Medicine, Volume 16, Issue 6, June 2026.
1. Lactate‐derived histone lactylation links glycolytic reprogramming to epigenetic regulation in female reproductive diseases. 2. In endometriosis, lactylation may promote inflammatory remodelling, immune dysregulation and ferroptosis resistance. 3. In PCOS, lactylation connects metabolic disturbance to granulosa‐cell dysfunction and hyperandrogenism.
Jiajun Qiao   +5 more
wiley   +1 more source

Varnimcabtagene autoleucel (ARI‐0001) in relapsed or refractory mantle cell lymphoma

open access: yesHemaSphere, Volume 10, Issue 5, May 2026.
Abstract Varnimcabtagene autoleucel (var‐cel) is an autologous CD19‐directed chimeric antigen receptor (CAR) T‐cell therapy administered using an adaptive, fractionated dosing strategy. We conducted a multicenter retrospective study to evaluate the safety and efficacy of var‐cel in patients with relapsed or refractory (R/R) mantle cell lymphoma (MCL ...
Nil Albiol   +41 more
wiley   +1 more source

Identification of biomarkers for GNE myopathy

open access: yesThe FASEB Journal, 2012
GNE‐myopathy is an autosomal recessive disorder characterized by muscle atrophy and weakness, and accumulation of amyloid proteins and rimmed vacuoles in myofibers. This disease is secondary to mutations in the GNE gene, which encodes an essential enzyme in sialic acid biosynthesis. Recently,
May Christine Malicdan   +3 more
openaire   +1 more source

The BET PROTAC inhibitor GNE-987 displays anti-tumor effects by targeting super-enhancers regulated gene in osteosarcoma

open access: yesBMC Cancer
Background Osteosarcoma (OS) is one of the most common primary malignant tumors of bone in children, which develops from osteoblasts and typically occurs during the rapid growth phase of the bone.
Di Wu   +14 more
doaj   +1 more source

Estimation of the Internal Temperature of High-Capacity Li-Ion Cells Using Embedded Impedancemetry

open access: yesIEEE Open Journal of Vehicular Technology
The internal temperature of electrochemical accumulators is a crucial parameter that significantly impacts their aging and safety. In particular, the phenomenon of thermal runaway must be detected early due to its rapid progression and potentially ...
Charles Bechara   +3 more
doaj   +1 more source

Supplementation of Nicotinic Acid with NAMPT Inhibitors Results in Loss of In Vivo Efficacy in NAPRT1-Deficient Tumor Models

open access: yesNeoplasia: An International Journal for Oncology Research, 2013
Nicotinamide adenine dinucleotide (NAD) is a metabolite essential for cell survival and generated de novo from tryptophan or recycled from nicotinamide (NAM) through the nicotinamide phosphoribosyltransferase (NAMPT)-dependent salvage pathway ...
Thomas O'Brien   +17 more
doaj   +1 more source

Antitumor Activity of USP7 Inhibitor GNE-6776 in Non-Small Cell Lung Cancer Involves Regulation of Epithelial-Mesenchymal Transition, Cell Cycle, Wnt/β-Catenin, and PI3K/AKT/mTOR Pathways

open access: yesPharmaceuticals
Objective: Non-small cell lung cancer (NSCLC) is a major cause of cancer-related deaths worldwide. This study investigated the effects and mechanisms of the USP7 inhibitor GNE-6776 on human NSCLC A549 and H1299 cells, providing insights for anti-NSCLC ...
Lipeng Wu   +12 more
doaj   +1 more source

Gelatin Nanoemulsion-Based Co-Delivery of Terbinafine and Essential Oils for Treatment of Candida albicans Biofilms

open access: yesMicroorganisms
Fungal infections represent a significant global health challenge. Candida albicans is a particularly widespread pathogen, with both molecular and biofilm-based mechanisms making it resistant to or tolerant of available antifungal drugs.
Muhammad Aamir Hassan   +6 more
doaj   +1 more source

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