Results 71 to 80 of about 5,472 (195)

Glucose Metabolism Regulating Colorectal Cancer Initiation and Progression

Cancer Science, Volume 117, Issue 5, Page 1199-1208, May 2026.
Drugs and compounds targeting glycolysis in CRC and the mechanisms by which these drugs inhibit their respective targets. ABSTRACT Colorectal cancer (CRC) is one of the most common types of invasive cancer worldwide, which has the characteristics of poor curative effect and poor prognosis. Increasing evidence suggests that hyperactivated glucose uptake
Meiyi Lin, Junpeng Cui
wiley   +1 more source

Sialidase Neu3 Induced Sialic Acid Disorder and Promoted Vascular Endothelial Injury Through Transcription Factor SP3

Journal of Cellular and Molecular Medicine, Volume 30, Issue 9, May 2026.
ABSTRACT Atherosclerotic cardiovascular disease is still a major cause for the increasing mortality worldwide. The elevated metabolite N‐acetylneuraminic acid (Neu5Ac) was considered one of the important risk factors responsible for the initiation of endothelial impairment, then participated in atherosclerosis progression.
Yining Lu, Peng Xiang, Qingqiu Chen, Xianmin Wang, Le Chen, Tongchuan Wang, Rong Hu, Limei Ma, Chao Yu   +8 more
wiley   +1 more source

Immunoblotting of muscle of Gne^+/+ and Gne^M712T/M712T mice.

, 2013
Immunoblots of muscle extracts from Gne+/+ and GneM712T/M712T showed no apparent difference in GNE protein expression (upper band, arrow, 79 kDa) in GneM712T/M712T mice compared with Gne+/+ littermates.
Zoé Coulombe (365862), Jacques P. Tremblay (304709), Thomas Paccalet (222440)   +2 more
core   +1 more source

DataSheet1_Generation and characterization of a novel gne Knockout Model in Zebrafish.docx

, 2022
GNE Myopathy is a rare, recessively inherited neuromuscular worldwide disorder, caused by a spectrum of bi-allelic mutations in the human GNE gene. GNE encodes a bi-functional enzyme responsible for the rate-limiting step of sialic acid biosynthesis ...
Tom Avital (13999905), Stella Mitrani-Rosenbaum (216109), Hagay Livne (13999902), Shmuel Ruppo (13999908), Avi Harazi (13999911), Alon Daya (13999914)   +5 more
core   +1 more source

4472 Plasma Neurofilament Light as a Biomarker for Pediatric Patients with Huntington’s Disease

Journal of Clinical and Translational Science, 2020
OBJECTIVES/GOALS: The goal of this study is to compare plasma neurofilament light (NfL) concentrations in asymptomatic children and young adults that carry the gene expansion (GE group) that causes Huntington’s Disease to similar subjects that do not ...
Jordan L Schultz
doaj   +1 more source

Introducing needs‐based epilepsy follow‐up: Patient satisfaction compared to standard of care follow‐up

Epileptic Disorders, Volume 28, Issue 2, Page 470-481, April 2026.
Abstract Background People with epilepsy have diverse healthcare needs, but limited resources make tailored management challenging. To allocate resources where they are most urgently required, we developed an openly available needs‐based follow‐up model.
Isak Birkeland, Eline Dahl‐Hansen, Marte Roa Syvertsen, Eivind Kolstad, Yvonne Myrtvedt Wollertsen, Atle Lillebø, Solveig Øvrebø, Elin Ese, Amund Leinaas, Nils Erik Gilhus, Marte Helene Bjørk   +10 more
wiley   +1 more source

DNA methylation abnormalities induced by advanced maternal age in villi prime a high-risk state for spontaneous abortion

Clinical Epigenetics, 2023
Background Advanced maternal age (AMA) has increased in many high-income countries in recent decades. AMA is generally associated with a higher risk of various pregnancy complications, and the underlying molecular mechanisms are largely unknown.
Meng Qin, Wei Chen, Lingyue Hua, Yan Meng, Jing Wang, Hanna Li, Rui Yang, Liying Yan, Jie Qiao   +8 more
doaj   +1 more source

Novel GNE mutations in three Chinese patients with typical GNE myo-pathy.

JPMA. The Journal of the Pakistan Medical Association, 2021
GNE myopathy is an adult-onset muscle disorder featuring distal muscle atrophy and weakness. Rimmed vacuoles found in the muscle biopsies and gene mutations lead to the diagnosis of GNE myopathy. We collected clinical information, performed muscle biopsies and genetic testing on three patients.
Rui, Ban, Xianghui, Lu, Chuanqiang, Pu, Huifang, Wang, Huaxu, Liu, Yutong, Zhang, Qiang, Shi   +6 more
openaire   +1 more source

Effects of Immunoadsorption on Markers of Iron Metabolism: A Case Series

Journal of Clinical Apheresis, Volume 41, Issue 2, April 2026.
ABSTRACT Immunoadsorption selectively eliminates circulating antibodies in antibody‐mediated diseases. Iron deficiency is the most common cause of anemia; however, the potential role of immunoadsorption in contributing to iron depletion remains insufficiently established.
Noemi E. Ginthör, Tobias Niedrist, Gerold Schwantzer, Alexander H. Kirsch, Werner Ribitsch, Andras Deak, Michael Kolland, Daniel Leitinger, Kathrin Eller, Alexander R. Rosenkranz, Katharina Artinger   +10 more
wiley   +1 more source

Supervised Swin Transformer‐Based Predictive Lithological Mapping and Uncertainty Quantification Using Aeromagnetic and Gravity Data

Journal of Geophysical Research: Machine Learning and Computation, Volume 3, Issue 2, April 2026.
Abstract Lithological mapping is essential for the exploration of critical minerals supporting energy transition and national defense. Although recent advancements have incorporated multi‐source data sets and leveraged machine learning and deep learning (DL) methods, lithological mapping continues to face significant challenges, such as data imbalance,
Liang Ding, Gilles Bellefleur, Olivier Boulanger, Phuong Vo   +3 more
wiley   +1 more source