Results 91 to 100 of about 5,472 (195)

Differenzierung von Wildtyp und GNE-defizienten murinen embryonalen Stammzellen in „Embryoid bodies“ [PDF]

, 2013
Die UDP-N-Acetylglukosamin-2-Epimerase/N-Acetylmannosamin-Kinase (GNE) ist das Schlüsselenzym im Biosyntheseweg der Sialinsäuren. Bei dem Versuch eine GNE-defiziente Maus zu generieren, zeigte sich, dass murine GNE-defiziente Embryonen am Tag 8.5 ...
Hering, Jessica
core   +1 more source

Die C57BL/6 GNE+/-Maus als Modell für die hereditäre Einschlusskörpermyopathie Typ 2 (h-IBM2) [PDF]

, 2016
Die folgende Arbeit befasst sich mit der Fragestellung, ob das von Schwarzkopf et al. generierte GNE+/- Mausmodell ein Modell für die Einschlusskörpermyopathie (GNE Myoptahie) darstellen kann.
Großmann, Mona
core   +1 more source

Evaluation of the Sialidase Inhibitor Oseltamivir in GNE-associated Thrombocytopenia

, 2021
Background: GNE encodes UDP-N-acetyl-glucosamine-2-epimerase/N-acetylmannosamine kinase, the rate limiting enzyme of sialic acid biosynthesis. Biallelic variants in GNE have recently been associated with severe isolated macrothrombocytopenia, attributed ...
Rossing, Maria, Leinoe, Eva, Zetterberg, Eva, Martin, Myriam, Blom, A.M., Fager Ferrari, Marcus, Ek, Torben, Smolag Klosowska, Karolina   +7 more
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Induction of GNE in Myofibers after Muscle Injury

, 2010
<i>Objective:</i> The aim of the present study was to clarify the expression of uridine diphospho-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase (GNE) protein and mRNA in damaged or regenerating myofibers.
Yasunori Higuchi, Yoshiyuki Tsukamoto, Kenichiro Nakamura, Shigeo Yokoyama, Toshihide Kumamoto, Shinji Yano, Naoki Hijiya, Masatsugu Moriyama   +7 more
core   +1 more source

Supplementation of Nicotinic Acid with NAMPT Inhibitors Results in Loss of In Vivo Efficacy in NAPRT1-Deficient Tumor Models

Neoplasia: An International Journal for Oncology Research, 2013
Nicotinamide adenine dinucleotide (NAD) is a metabolite essential for cell survival and generated de novo from tryptophan or recycled from nicotinamide (NAM) through the nicotinamide phosphoribosyltransferase (NAMPT)-dependent salvage pathway ...
Thomas O'Brien, Jason Oeh, Yang Xiao, Xiaorong Liang, Alexander Vanderbilt, Ann Qin, Lulu Yang, Leslie B. Lee, Justin Ly, Ely Cosino, Jennifer A. LaCap, Annie Ogasawara, Simon Williams, Michelle Nannini, Bianca M. Liederer, Peter Jackson, Peter S. Dragovich, Deepak Sampath   +17 more
doaj   +1 more source

Antitumor Activity of USP7 Inhibitor GNE-6776 in Non-Small Cell Lung Cancer Involves Regulation of Epithelial-Mesenchymal Transition, Cell Cycle, Wnt/β-Catenin, and PI3K/AKT/mTOR Pathways

Pharmaceuticals
Objective: Non-small cell lung cancer (NSCLC) is a major cause of cancer-related deaths worldwide. This study investigated the effects and mechanisms of the USP7 inhibitor GNE-6776 on human NSCLC A549 and H1299 cells, providing insights for anti-NSCLC ...
Lipeng Wu, Long Lin, Meng Yu, Huajian Li, Yuanye Dang, Huosheng Liang, Guangyang Chen, Halimulati Muhetaer, Guodong Zheng, Jingjing Li, Xuejing Jia, Bo Wu, Chuwen Li   +12 more
doaj   +1 more source

Gelatin Nanoemulsion-Based Co-Delivery of Terbinafine and Essential Oils for Treatment of Candida albicans Biofilms

Microorganisms
Fungal infections represent a significant global health challenge. Candida albicans is a particularly widespread pathogen, with both molecular and biofilm-based mechanisms making it resistant to or tolerant of available antifungal drugs.
Muhammad Aamir Hassan, Sadaf Noor, Jungmi Park, Ahmed Nabawy, Maitri Dedhiya, Robin Patel, Vincent M. Rotello   +6 more
doaj   +1 more source

Effects of mutated GNE^M712T on ST3Gal5 mRNA expression.

, 2013
A, Comparison of GNE mRNA levels between Gne+/+ (diamond) and GneM712T/M712T (square) mouse muscle determined by qRT-PCR (absolute values are expressed as the number of GNE mRNA copies/µg of total RNA).
Zoé Coulombe (365862), Jacques P. Tremblay (304709), Thomas Paccalet (222440)   +2 more
core   +1 more source

The Gne M712T Mouse as a Model for Human Glomerulopathy

The American Journal of Pathology, 2012
Pathological glomerular hyposialylation has been implicated in certain unexplained glomerulopathies, including minimal change nephrosis, membranous glomerulonephritis, and IgA nephropathy. We studied our previously established mouse model carrying a homozygous mutation in the key enzyme of sialic acid biosynthesis, N-acetylglucosamine 2-epimerase/N ...
Kakani, Sravan, Yardeni, Tal, Poling, Justin, Ciccone, Carla, Niethamer, Terren, Klootwijk, Enriko D., Manoli, Irini, Darvish, Daniel, Hoogstraten-Miller, Shelley, Zerfas, Patricia, Tian, E., Ten Hagen, Kelly G., Kopp, Jeffrey B., Gahl, William A., Huizing, Marjan   +14 more
openaire   +2 more sources

Comparative data about wild type C57Bl/6 GNE+/+ and heterozygous C57Bl/6 GNE+/− mice.

, 2013
±SD; range in parentheses; n.s., not significant. Data are meanGNE+/+ and C57Bl/6 GNE+/− at 24 weeks and at 80 weeks. There was no statistical difference between the parameters in C57Bl/6
Hans-Jürgen Holzhausen (495614), Joachim Weis (362221), Stephan Zierz (159096), Rüdiger Horstkorte (495616), Frank Hanisch (495610), Wenke Weidemann (495611), Pushpa Raj Joshi (495613), Mona Großmann (495612), Gisela Stoltenburg (495615)   +8 more
core   +1 more source