Results 41 to 50 of about 5,472 (195)
Microbiology Spectrum, 2023 Replication of influenza A virus (IAV) is highly reliant on host cell function, and to identify the key host factor required in the influenza A virus life cycle, a genome-wide CRISPR/Cas9 knockout (KO) screen was conducted in A549 cells infected by H1N1 ...
Tianxin Ma +17 more
doaj +1 more source
Sialylation and muscle performance: sialic acid is a marker of muscle ageing.
PLoS ONE, 2013 Sialic acids (Sia) are widely expressed as terminal monosaccharides on eukaryotic glycoconjugates. They are involved in many cellular functions, such as cell-cell interaction and signal recognition.
Frank Hanisch +8 more
doaj +1 more source
Altered Actin Dynamics in Cell Migration of GNE Mutant Cells
Frontiers in Cell and Developmental Biology, 2021 Cell migration is an essential cellular process that requires coordination of cytoskeletal dynamics, reorganization, and signal transduction. The actin cytoskeleton is central in maintaining the cellular structure as well as regulating the mechanisms of ...
Shamulailatpam Shreedarshanee Devi +2 more
doaj +1 more source
A novel mutation in GNE gene: clinical characteristics and bioinformatics analysis
Chinese Journal of Contemporary Neurology and Neurosurgery, 2018 Objective To report and summarize clinical phenotype and genotype characteristics in a patient with GNE myopathy, and to extend mutation spectrum of GNE gene.
Liang WANG +7 more
doaj +1 more source
Fighting the Cause of Alzheimer’s and GNE Myopathy [PDF]
Frontiers in Neuroscience, 2018 Age is the common risk factor for both neurodegenerative and neuromuscular diseases. Alzheimer disease (AD), a neurodegenerative disorder, causes dementia with age progression while GNE myopathy (GNEM), a neuromuscular disorder, causes muscle degeneration and loss of muscle motor movement with age.
Shreedarshanee Devi +3 more
openaire +3 more sources
Dissecting role of founder mutation p.V727M in GNE in Indian HIBM cohort
Open Medicine, 2021 GNE gene-specific c.2179G>A(p.V727M) is a key alteration reported in patients with hereditary inclusion body myopathy (HIBM) and represents an ethnic founder mutation in the Indian cohort.
Attri Shivangi +4 more
doaj +1 more source
Loss of GNE Predicts Lymph Node Metastasis in Early Gastric Cancer
Cells, 2022 Endoscopic surgery is increasingly utilized for the treatment of early gastric cancer (EGC) worldwide, whereas lymph node metastasis (LNM) remains a critical risk factor for the relapse of EGC after endoscopic surgery.
Xinying Guo +8 more
doaj +1 more source
IEEE AccessRailway systems are increasingly digitalized and interconnected, making cybersecurity a safety-relevant concern in safety-critical cyber–physical operations.
Yasmine Benghename +2 more
doaj +1 more source
GNE-617 reduces NAD levels in sensitive and resistant cell lines.
, 2016 A) Structure of GNE-617 with its biochemical IC50 for NAMPT. B) Correlation between NAMPT protein levels and sensitivity to GNE-617 (IC50) determined in a 4-day viability assay.
Anneleen Daemen (365394) +6 more
core +1 more source
Myogenesis defects in a patient-derived iPSC model of hereditary GNE myopathy
npj Regenerative Medicine, 2022 Hereditary muscle diseases are disabling disorders lacking effective treatments. UDP-N-acetylglucosamine-2-epimerase/N-acetylmannosamine kinase (GNE) myopathy (GNEM) is an autosomal recessive distal myopathy with rimmed vacuoles typically manifesting in ...
Rebecca E. Schmitt +8 more
doaj +1 more source