Mechanistic role of GNE-987 targeting BRD4-HCP5 axis in pediatric T-cell acute lymphoblastic leukemia. [PDF]
J Cell Commun SignalAbstract This study aims to explore the mechanism of action of the Bromodomain‐containing protein 4 (BRD4) inhibitor GNE‐987 in the treatment of pediatric T‐cell Acute Lymphoblastic Leukemia (T‐ALL), focusing on its effect in inhibiting T‐ALL cell proliferation by activating the HLA Complex P5 (HCP5) Super‐enhancer.
Sang X +6 more
europepmc +2 more sources
[<i>GNE</i> gene-related thrombocytopenia: a case report and literature review]. [PDF]
Zhongguo Dang Dai Er Ke Za ZhiLin S, Chen XJ.
europepmc +2 more sources
Inhibitory Effects of Grapefruit Seed Extract and Its Nanoemulsion on Biofilm Formation of Escherichia coli and Staphylococcus aureus [PDF]
Shipin Kexue, 2023 Purpose: To investigate the inhibitory effects of grapefruit seed extract (GSE) and its nanoemulsion (GNE) on biofilm formation of Escherichia coli and Staphylococcus aureus.
WANG Siqi, LIANG Xiaoyun, ZHANG Chen, ZHANG Wendong, CHENG Yu, MI Xiaoyu, ZHAO Wangchen, WANG Longfeng, JIANG Yun
doaj +1 more source
GNE-493 inhibits prostate cancer cell growth via Akt-mTOR-dependent and -independent mechanisms
Cell Death Discovery, 2022 GNE-493 is a novel PI3K/mTOR dual inhibitor with improved metabolic stability, oral bioavailability, and excellent pharmacokinetic parameters. Here GNE-493 potently inhibited viability, proliferation, and migration in different primary and established ...
Lu Jin +5 more
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Ganglioside GM3 levels are altered in a mouse model of HIBM: GM3 as a cellular marker of the disease. [PDF]
PLoS ONE, 2010 ObjectiveHIBM (Hereditary Inclusion Body Myopathy) is a recessive hereditary disease characterized by adult-onset, slowly progressive muscle weakness sparing the quadriceps.
Thomas Paccalet +2 more
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GluN2A NMDA Receptor Enhancement Improves Brain Oscillations, Synchrony, and Cognitive Functions in Dravet Syndrome and Alzheimer's Disease Models. [PDF]
, 2020 NMDA receptors (NMDARs) play subunit-specific roles in synaptic function and are implicated in neuropsychiatric and neurodegenerative disorders. However, the in vivo consequences and therapeutic potential of pharmacologically enhancing NMDAR function via
Chan, Connie +25 more
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GNE is involved in the early development of skeletal and cardiac muscle. [PDF]
PLoS ONE, 2011 UDP-N-acetylglucosamine 2 epimerase/N-acetylmannosamime kinase (GNE) is a bifunctional enzyme which catalyzes the two key sequential steps in the biosynthetic pathway of sialic acid, the most abundant terminal monosaccharide on glycoconjugates of ...
Irit Milman Krentsis +6 more
doaj +1 more source
médecine/sciences, 2017 Malgre un essai de phase II prometteur, l’acide sialique a liberation prolongee n’a pas confirme son efficacite sur une plus large population de patients. Une deception certaine, mais d’autres pistes therapeutiques restent ouvertes comme evoque lors des 23e Journees Neuromusculaires a Marseille les 6 et 7 septembre derniers.
Sylvie Marion +2 more
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Journal of Immunology Research, 2022 Background. AML (acute myeloid leukemia) is a common hematological malignancy in children with poor treatment effects and poor prognosis. Recent studies have shown that as a novel BRD4 (bromodomain containing 4) PROTACs (proteolysis targeting chimeras ...
Xu Sang +22 more
doaj +1 more source
The New PI3K/mTOR Inhibitor GNE-477 Inhibits the Malignant Behavior of Human Glioblastoma Cells
Frontiers in Pharmacology, 2021 The most common primary central nervous system tumor in adults is glioblastoma multiforme (GBM). The high invasiveness of GBM cells is an important factor leading to inevitable tumor recurrence and a poor prognosis of patients. GNE-477, a novel PI3K/mTOR
Yixuan Wang +24 more
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