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GnRHs and GnRH receptors

Animal Reproduction Science, 2005
GnRH is the pivotal hypothalamic hormone regulating reproduction. Over 20 forms of the decapeptide have been identified in which the NH2- and COOH-terminal sequences, which are essential for receptor binding and activation, are conserved. In mammals, there are two forms, GnRH I which regulates gonadotropin and GnRH II which appears to be a ...
Robert P Millar
exaly   +3 more sources

GnRH in pregnancy

Archives of Gynecology and Obstetrics, 1996
Human trophoblast produce GnRH and its precursor, immunologically and chemically identical to those of hypothalamic origin. Placental GnRH stimulates human chorionic gonadotropin secretion by the syncytiotrophoblast. It is known that GnRH analogue has negative effect on early rat pregnancy and may cause abortion through its action on the corpus luteum.
J, Gohar, M, Mazor, J R, Leiberman
openaire   +2 more sources

Evolutionary aspects of GnRHs, GnRH neuronal systems and GnRH receptors in teleost fish

General and Comparative Endocrinology, 2004
Gonadotrophin-releasing hormone (GnRH) was originally believed to be released by a unique set of hypophysiotrophic neurons to stimulate the release of gonadotrophins from the pituitary, therefore acting as a major initiator of the hormonal cascade controlling the reproductive axis.
JOSÉ A Muñoz-Cueto   +2 more
exaly   +5 more sources

GnRH Secretion into CSF in Rams Treated With a GnRH Antagonist

Journal of Neuroendocrinology, 1997
The equilibrium of the brain‐pituitary‐testicular axis is controlled by negative feedback exerted primarily through changes in the circulating concentrations of gonadal steroids. This is usually studied in gonadectomised animals treated with single large doses or constant low levels of exogenous steroid.
Blache, D.   +6 more
openaire   +3 more sources

GnRH and GnRH receptors in metazoa: A historical, comparative, and evolutive perspective

General and Comparative Endocrinology, 2007
About 50years after Harris's first demonstration of its existence, GnRH has strongly stimulated the interest and imagination of scientists, resulting in a high number of studies in an increasing number of species. For the endocrinologist, GnRH, via its actions on the synthesis and release of pituitary gonadotrophins, is first an essential hormone for ...
Olivier Kah   +2 more
exaly   +6 more sources

Mitochondrial dysfunction in GnRH neurons impaired GnRH production

Biochemical and Biophysical Research Communications, 2020
The onset establishment and maintenance of gonadotropin-releasing hormone (GnRH) secretion is an important phenomenon regulating pubertal development and reproduction. GnRH neurons as well as other neurons in the hypothalamus have high-energy demands and require a constant energy supply from their mitochondria machinery to maintain active functioning ...
Yoshiteru Kagawa   +11 more
openaire   +2 more sources

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