Results 171 to 180 of about 50,034 (219)
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Clinical Obstetrics and Gynecology, 1989
The development of GnRH agonists has had a major impact on the practice of gynecology and reproductive endocrinology. The clinical usefulness of GnRH agonists will increase as modes of administration are improved and indications become better defined. GnRH agonists and, potentially, antagonists will provide a prompt, effective, and reversible method of
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The development of GnRH agonists has had a major impact on the practice of gynecology and reproductive endocrinology. The clinical usefulness of GnRH agonists will increase as modes of administration are improved and indications become better defined. GnRH agonists and, potentially, antagonists will provide a prompt, effective, and reversible method of
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Endocrinology
Abstract GnRH is traditionally recognized as the central regulator of reproduction through its pulsatile secretion, which governs the hypothalamic-pituitary-gonadal axis. However, recent evidence has highlighted its broader role in brain development and function, including in cognitive and higher intellectual processes.
Loïc Kacimi, Vincent Prevot
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Abstract GnRH is traditionally recognized as the central regulator of reproduction through its pulsatile secretion, which governs the hypothalamic-pituitary-gonadal axis. However, recent evidence has highlighted its broader role in brain development and function, including in cognitive and higher intellectual processes.
Loïc Kacimi, Vincent Prevot
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GnRH II and type II GnRH receptors
Trends in Endocrinology & Metabolism, 2003Hypothalamic gonadotrophin-releasing hormone (GnRH I), which is of a variable structure in vertebrates, is the central regulator of the reproductive system through its stimulation of gonadotrophin release from the pituitary. A second form of GnRH (GnRH II) is ubiquitous and conserved in structure from fish to humans, suggesting that it has important ...
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GnRH receptors and GnRH endocrine effects on luteoma cells
Endocrine, 1997An ovary implanted into the spleen of an ovariectomized rat develops into a luteinized tumor, growing in response to gonadotrophins. Previously, it was shown that in vivo Buserelin, a gonadotrophin-releasing hormone (GnRH) analog, inhibited tumor growth.
A, Chamson-Reig +3 more
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GnRH and GnRH receptors: distribution, function and evolution
Journal of Fish Biology, 2008Gonadotropin‐releasing hormone (GnRH) was originally identified because of its essential role in regulating reproduction in all vertebrates. Since then, three phylogenetically related GnRH decapeptides have been characterized in vertebrates and invertebrates.
C.‐C. Chen, R. D. Fernald
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Frontiers in Bioscience, 2002
Gonadotropin-releasing-hormone (GnRH) analogues are synthetic compounds derived from decapeptide neurohormones (LHRH; LH/FSH-RH). They have a key role in hormone dependent cancer, particularly breast and prostate cancer. GnRH analogues produce an efficient inhibition of gonadotropins and sex steroid hormones.
FLORIO S. +5 more
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Gonadotropin-releasing-hormone (GnRH) analogues are synthetic compounds derived from decapeptide neurohormones (LHRH; LH/FSH-RH). They have a key role in hormone dependent cancer, particularly breast and prostate cancer. GnRH analogues produce an efficient inhibition of gonadotropins and sex steroid hormones.
FLORIO S. +5 more
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Animal Reproduction Science, 2005
Advances in our understanding of the complexity of GnRH actions at the pituitary and the various mechanisms involved in mediating differential LH and FSH biosynthesis and secretion at the gonadotrope, are continually emerging. In this review, we summarise recent studies pertaining to GnRH and GnRH receptor phylogeny, the divergent signalling and ...
Adam J, Pawson, Alan S, McNeilly
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Advances in our understanding of the complexity of GnRH actions at the pituitary and the various mechanisms involved in mediating differential LH and FSH biosynthesis and secretion at the gonadotrope, are continually emerging. In this review, we summarise recent studies pertaining to GnRH and GnRH receptor phylogeny, the divergent signalling and ...
Adam J, Pawson, Alan S, McNeilly
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GnRH analogues for contraception
British Medical Bulletin, 1993The production of chemical analogues of GnRH permits direct suppression of the pituitary-gonadal axis at the level of the gonadotroph. Continuous administration of GnRH agonists desensitizes the gonadotroph and ovulation is uniformly prevented, forming the practical basis for use in contraception. However, long-term treatment is constrained by variable
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2002
Publisher Summary An inspection of the deduced amino acid sequences from the nine complementary pro-GnRH forms demonstrates several points. All pro-gonadotropin-releasing hormone (GnRH) proteins contain GnRH at their N-termini and the peptide is separated by a putative processing site from GnRH-associated peptide (GAP).
William C, Wetsel, Sudha, Srinivasan
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Publisher Summary An inspection of the deduced amino acid sequences from the nine complementary pro-GnRH forms demonstrates several points. All pro-gonadotropin-releasing hormone (GnRH) proteins contain GnRH at their N-termini and the peptide is separated by a putative processing site from GnRH-associated peptide (GAP).
William C, Wetsel, Sudha, Srinivasan
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GnRH in the invertebrates: an overview
2002Publisher Summary This chapter provides an overview of GnRH in the invertebrates. The gonadotropin-releasing hormone (GnRH), which was previously called luteinizing hormone-releasing hormone (LHRH), represents a pivotal peptide in animal reproduction.
RASTOGI R. K. +4 more
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