Results 191 to 200 of about 50,245 (245)
Some of the next articles are maybe not open access.
GnRH Secretion into CSF in Rams Treated With a GnRH Antagonist
Journal of Neuroendocrinology, 1997The equilibrium of the brain‐pituitary‐testicular axis is controlled by negative feedback exerted primarily through changes in the circulating concentrations of gonadal steroids. This is usually studied in gonadectomised animals treated with single large doses or constant low levels of exogenous steroid.
Blache, D. +6 more
openaire +3 more sources
Clinical Obstetrics and Gynecology, 1989
The development of GnRH agonists has had a major impact on the practice of gynecology and reproductive endocrinology. The clinical usefulness of GnRH agonists will increase as modes of administration are improved and indications become better defined. GnRH agonists and, potentially, antagonists will provide a prompt, effective, and reversible method of
openaire +2 more sources
The development of GnRH agonists has had a major impact on the practice of gynecology and reproductive endocrinology. The clinical usefulness of GnRH agonists will increase as modes of administration are improved and indications become better defined. GnRH agonists and, potentially, antagonists will provide a prompt, effective, and reversible method of
openaire +2 more sources
Mitochondrial dysfunction in GnRH neurons impaired GnRH production
Biochemical and Biophysical Research Communications, 2020The onset establishment and maintenance of gonadotropin-releasing hormone (GnRH) secretion is an important phenomenon regulating pubertal development and reproduction. GnRH neurons as well as other neurons in the hypothalamus have high-energy demands and require a constant energy supply from their mitochondria machinery to maintain active functioning ...
Yoshiteru Kagawa +11 more
openaire +2 more sources
Endocrinology
Abstract GnRH is traditionally recognized as the central regulator of reproduction through its pulsatile secretion, which governs the hypothalamic-pituitary-gonadal axis. However, recent evidence has highlighted its broader role in brain development and function, including in cognitive and higher intellectual processes.
Loïc Kacimi, Vincent Prevot
openaire +2 more sources
Abstract GnRH is traditionally recognized as the central regulator of reproduction through its pulsatile secretion, which governs the hypothalamic-pituitary-gonadal axis. However, recent evidence has highlighted its broader role in brain development and function, including in cognitive and higher intellectual processes.
Loïc Kacimi, Vincent Prevot
openaire +2 more sources
GnRH II and type II GnRH receptors
Trends in Endocrinology & Metabolism, 2003Hypothalamic gonadotrophin-releasing hormone (GnRH I), which is of a variable structure in vertebrates, is the central regulator of the reproductive system through its stimulation of gonadotrophin release from the pituitary. A second form of GnRH (GnRH II) is ubiquitous and conserved in structure from fish to humans, suggesting that it has important ...
openaire +2 more sources
GnRH receptors and GnRH endocrine effects on luteoma cells
Endocrine, 1997An ovary implanted into the spleen of an ovariectomized rat develops into a luteinized tumor, growing in response to gonadotrophins. Previously, it was shown that in vivo Buserelin, a gonadotrophin-releasing hormone (GnRH) analog, inhibited tumor growth.
A, Chamson-Reig +3 more
openaire +2 more sources
GnRH and GnRH receptors: distribution, function and evolution
Journal of Fish Biology, 2008Gonadotropin‐releasing hormone (GnRH) was originally identified because of its essential role in regulating reproduction in all vertebrates. Since then, three phylogenetically related GnRH decapeptides have been characterized in vertebrates and invertebrates.
C.‐C. Chen, R. D. Fernald
openaire +1 more source
Frontiers in Bioscience, 2002
Gonadotropin-releasing-hormone (GnRH) analogues are synthetic compounds derived from decapeptide neurohormones (LHRH; LH/FSH-RH). They have a key role in hormone dependent cancer, particularly breast and prostate cancer. GnRH analogues produce an efficient inhibition of gonadotropins and sex steroid hormones.
FLORIO S. +5 more
openaire +5 more sources
Gonadotropin-releasing-hormone (GnRH) analogues are synthetic compounds derived from decapeptide neurohormones (LHRH; LH/FSH-RH). They have a key role in hormone dependent cancer, particularly breast and prostate cancer. GnRH analogues produce an efficient inhibition of gonadotropins and sex steroid hormones.
FLORIO S. +5 more
openaire +5 more sources
Animal Reproduction Science, 2005
Advances in our understanding of the complexity of GnRH actions at the pituitary and the various mechanisms involved in mediating differential LH and FSH biosynthesis and secretion at the gonadotrope, are continually emerging. In this review, we summarise recent studies pertaining to GnRH and GnRH receptor phylogeny, the divergent signalling and ...
Adam J, Pawson, Alan S, McNeilly
openaire +2 more sources
Advances in our understanding of the complexity of GnRH actions at the pituitary and the various mechanisms involved in mediating differential LH and FSH biosynthesis and secretion at the gonadotrope, are continually emerging. In this review, we summarise recent studies pertaining to GnRH and GnRH receptor phylogeny, the divergent signalling and ...
Adam J, Pawson, Alan S, McNeilly
openaire +2 more sources
GnRH analogues for contraception
British Medical Bulletin, 1993The production of chemical analogues of GnRH permits direct suppression of the pituitary-gonadal axis at the level of the gonadotroph. Continuous administration of GnRH agonists desensitizes the gonadotroph and ovulation is uniformly prevented, forming the practical basis for use in contraception. However, long-term treatment is constrained by variable
openaire +2 more sources