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Advanced Science, EarlyView.A biomimetic ultrasound‐responsive piRNA delivery nanoparticle platform (piR‐NPs) enables targeted delivery and ultrasound (US)‐triggered release of piR‐1873 in infarcted myocardium. The released piR‐1873 suppresses Usp2‐mediated RIP1/RIP3/MLKL necroptosis, reduces myocardial injury and fibrosis, and promotes cardiac functional recovery, providing a ...
Yajun Zhang +10 more
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Goal-Directed Therapy for Cardiac Surgery
Critical Care Clinics, 2020Goal-directed therapy couples therapeutic interventions with physiologic and metabolic targets to mitigate a patient's modifiable risks for death and complications. Goal-directed therapy attempts to improve quality-of-care metrics, including length of stay, rate of readmission, and cost per case.
Subhasis Chatterjee +2 more
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Perioperative goal-directed therapy – What is the evidence? [PDF]
Best Practice & Research Clinical Anaesthesiology, 2019 Perioperative goal-directed therapy aims at optimizing global hemodynamics during the perioperative period by titrating fluids, vasopressors, and/or inotropes to predefined hemodynamic goals. There is evidence on the benefit of perioperative goal-directed therapy, but its adoption into clinical practice is slow and incomprehensive.
Thomas, Kaufmann +2 more
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Current Pharmaceutical Design, 2012
The cornerstone of treating patients with shock remains as it has for decades, intravenous fluids. Surprisingly, dosing intravenous fluid during resuscitation of shock remains largely empirical. Recent data suggests that early aggressive resuscitation of critically ill patients may limit and/or reverse tissue hypoxia, progression to organ failure and ...
Paul E, Marik, Himanshu, Desai
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The cornerstone of treating patients with shock remains as it has for decades, intravenous fluids. Surprisingly, dosing intravenous fluid during resuscitation of shock remains largely empirical. Recent data suggests that early aggressive resuscitation of critically ill patients may limit and/or reverse tissue hypoxia, progression to organ failure and ...
Paul E, Marik, Himanshu, Desai
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2021
Since the publication of the landmark paper by Dr. Emanuel Rivers in The New England Journal of Medicine in 2001, the world of critical care massively adopted his protocol for the resuscitation of severe sepsis and/or septic shock—which was named “early goal-directed therapy” [1].
Pasquale Nardelli +2 more
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Since the publication of the landmark paper by Dr. Emanuel Rivers in The New England Journal of Medicine in 2001, the world of critical care massively adopted his protocol for the resuscitation of severe sepsis and/or septic shock—which was named “early goal-directed therapy” [1].
Pasquale Nardelli +2 more
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Goal-directed Therapy and Postcystectomy Ileus: Comment
Anesthesiology, 2021info:eu-repo/semantics ...
Wüthrich, Patrick Yves +2 more
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Goal-directed therapy to maintain haemostasis
Best Practice & Research Clinical Anaesthesiology, 2016Perioperative goal-directed therapy typically involves the use of haemodynamic targets to optimise oxygen delivery. Common goals include stroke volume, cardiac output and arterial blood pressure, although future protocols may also incorporate an assessment of vascular tone and the microcirculation.
C, Oscier, M, Cecconi
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Early goal-directed therapy versus “early”, “goal-directed” therapy
Intensive Care Medicine, 2015Dear Editor, I read with great interest the systematic review and meta-analysis by the ARISE, ProCESS and ProMISe investigators [1] that showed no difference in mortality between early goal-directed therapy (EGDT) and usual care in resuscitating patients with septic shock. I admire their work and this is a great opportunity to speak directly with them.
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