Results 51 to 60 of about 200,215 (293)

Keberhasilan Early Goal-Directed Therapy dan Faktor Pengganggu pada Pasien Sepsis Berat di Instalasi Gawat Darurat Rumah Sakit Dr. Hasan Sadikin Bandung yang Akan Menjalani Pembedahan

Jurnal Anestesi Perioperatif, 2015
Early goal-directed therapy (EGDT) is conducted to reduce morbidity and mortality in patients with severe sepsis and septic shock. The purpose of this study was to evaluate the success of EGDT in patients with severe sepsis in the emergency room (ER) of ...
Mira Silviana, Doddy Tavianto, Rudi K. Kadarsah   +2 more
doaj   +1 more source

Goal-Directed Fluid Therapy and major postoperative complications in elective craniotomy. A retrospective analysis of a before-after multicentric study

BMC Anesthesiology, 2023
Background Goal-Directed Fluid Therapy (GDFT) is recommended to decrease major postoperative complications. However, data are lacking in intra-cranial neurosurgery. Methods We evaluated the efficacy of a GDFT protocol in a before/after multi-centre study
Morgan Le Guen, Amandine Le Gall-Salaun, Julien Josserand, Augustin Gaudin de Vilaine, Simon Viquesnel, Damien Muller, Bertrand Rozec, Kévin Buffenoir Billet, Raphaël Cinotti, the Société Française d’Anesthésie-Réanimation–SFAR Research Network   +9 more
doaj   +1 more source

Goal-directed colloid administration improves the microcirculation of healthy and perianastomotic colon

, 2009
BACKGROUND: The aim of this study was to compare the effects of goal-directed colloid fluid therapy with goal-directed crystalloid and restricted crystalloid fluid therapy on healthy and perianastomotic colon tissue in a pig model of colon anastomosis ...
Hiltebrand, Luzius, Kimberger, Oliver, Arnberger, Michael, Brandt, Sebastian, Plock, Jan, Kurz, Andrea, Sigurdsson, Gisli H   +6 more
core   +1 more source

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

Efficacy of goal-directed fluid therapy monitored by pulse-pressure variation using a continuous noninvasive arterial pressure monitoring system (the CNAP TM system) during parathyroidectomy in patients with end-stage renal failure – a randomised trial

Archives of Medical Science, 2020
Introduction There are no well-recognised guidelines for intraoperative fluid management in patients with end-stage renal failure (ESRF). Goal-directed fluid therapy (GDFT) is a concept of perioperative fluid management that improves patients’ prognosis.
Jie Song, Xiaofen Liu, Weiwei Jiang, Jiayou Wang, Yun Li, Hong Chen, Ye Zhang   +6 more
doaj   +1 more source

Key components of early goal directed therapy.

, 2019
Key components of early goal directed therapy.
Rujipat Samransamruajkit (6470519), Thansinee Saetae (6470516), Krit Pongpirul (5735576)   +2 more
core   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Early Goal Directed Therapy: Do We Reach the End of Road?

Archives of Anesthesia and Critical Care, 2016
No ...
Ata Mahmoodpoor, Samad EJ Golzari
doaj  

Scoping Review of Goal Directed Therapy for Youth with Cerebral Palsy

, 2023
This scoping review aims to define goal directed therapy for youth with cerebral palsy and summarize the active ingredients of the intervention as it is presented in the literature.
Bridget Barry Thias, Angela Shierk, Aidan O'Brien, Heather Roberts   +3 more
core   +1 more source

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

FEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia, Masahiro Kimura, Daisuke Kurimoto, Atsushi Sato   +3 more
wiley   +1 more source