Archives of Medical Science, 2020 Introduction There are no well-recognised guidelines for intraoperative fluid management in patients with end-stage renal failure (ESRF). Goal-directed fluid therapy (GDFT) is a concept of perioperative fluid management that improves patients’ prognosis.
Jie Song +6 more
doaj +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Early Goal Directed Therapy: Do We Reach the End of Road?
Archives of Anesthesia and Critical Care, 2016 No ...
Ata Mahmoodpoor, Samad EJ Golzari
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Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
The Scientific World Journal, 2014 Increasing evidence shows that goal-directed hemodynamic management can improve outcomes in surgical and intensive care settings. Arterial waveform analysis is one of the different techniques used for guiding goal-directed therapy.
Neil Mehta +2 more
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Clinics, 2013 OBJECTIVES: This pilot study was designed to utilize stroke volume variation and cardiac index to ensure fluid optimization during one-lung ventilation in patients undergoing thoracoscopic lobectomies.
Jian Zhang +4 more
doaj +1 more source
Intra-Operative Fluid Management in Adult Neurosurgical Patients Undergoing Intracranial Tumour Surgery: Randomised Control Trial Comparing Pulse Pressure Variance (PPV) and Central Venous Pressure (CVP) [PDF]
Journal of Clinical and Diagnostic Research, 2016 Introduction: Fluid management in neurosurgery presents specific challenges to the anaesthesiologist. Dynamic parameters like Pulse Pressure Variation (PPV) have been used successfully to guide fluid management.
Shalini Cynthia Sundaram +3 more
doaj +1 more source
The impact of leukocyte‐associated RNA retention on platelet RNA‐based cancer detection
Molecular Oncology, EarlyView.Platelets carry RNA signals that may help detect cancer, but platelet samples can also retain RNA from white blood cells. We found that this retained white blood cell signal did not significantly affect machine learning cancer classification, suggesting that the cancer‐related RNA signal in platelets is largely independent of leukocyte‐associated RNA ...
Michał Sieczczyński +12 more
wiley +1 more source
Dreams and nightmares of the goal-directed therapy concept in anesthesia and intensive care
, 2014 Considerations on the appropriateness of goal-directed therapy concept evaluating the results of different ...
L. Gattinoni
core +2 more sources
Goal-directed fluid therapy optimizes hemodynamics on the elderly patients undergoing lumbar decompressive surgery and reduces postoperative complications [PDF]
Jichu yixue yu linchuang, 2021 Objective To explore the impact of goal-directed fluid therapy(GDT) management strategy on the perioperative complications of elderly patients undergoing lumbar spine surgery.
XIA Di, XU Li, LI Xu, HUANG Yu-guang
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