Results 61 to 70 of about 5,691,306 (287)

Sepsis in pregnancy and early goal-directed therapy [PDF]

Obstetric Medicine, 2009
Sepsis is a major cause of serious morbidity and mortality in pregnant women and their babies. Conventional management has evolved over many years. Improved understanding of the underlying pathophysiology and randomized clinical trials have led to recommendations for the formalization and standardization of the management of severe sepsis in non ...
Julie, Joseph, Aneeta, Sinha, Michael, Paech, Barry N J, Walters   +3 more
openaire   +2 more sources

Overcoming platinum resistance by the disulfiram metabolite CuET in novel preclinical models of human carcinomas

Molecular Oncology, EarlyView.
Cisplatin‐resistant cancer cells survive DNA‐damaging platinum‐based treatment yet remain sensitive to CuET‐induced proteotoxic stress. The distinct mechanism of action allows CuET to overcome and eliminate cisplatin‐resistant tumour cells, unless highly expressed metallothioneins (MTs) interfere with CuET, thereby highlighting MT levels as candidate ...
Stefanos Arampatzis, Tereza Buchtová, Jirina Bartkova, Marie Lund Bay, Christoffer Lynge Halvorsen, Zuzana Machacova, Zdenek Skrott, Martin Mistrik, Ekaterina Dulina, Miguel Andujar‐Sanchez, Estrid Høgdall, Tine Henrichsen Schnack, Claus Høgdall, Berit Jul Mosgaard, Marie Boennelycke, Jacob Brink Laursen, Allan Jensen, Susanne K. Kjær, Tuula Kallunki, Robert Strauss, Jiri Bartek   +20 more
wiley   +1 more source

New progress of goal-directed fluid therapy in enhanced recovery after surgery [PDF]

Jichu yixue yu linchuang, 2020
Goal-directed fluid therapy(GDFT) is an important method to accelerate patients rehabilitation after surgical operation. It can maintain the stability of hemodynamic indexes, balance of oxygen supply and demand, reduce the perioperative inflammatory ...
HE Xiao-yi, ZOU Xue-jun, XING Hao-ran
doaj  

From patient advocacy to patient‐driven research: Building active partnerships beginning at the bench to reach the bedside

FEBS Open Bio, EarlyView.
Research is strongest when conducted alongside patients, not just about them. Patient research organizations help integrate patient perspectives into research priorities, study design, and scientific meetings, leading to meaningful patient outcomes and development of relevant therapies.
Jenica H. Kakadia, Rachel Heilmann, Maximiliano Barrientos, Laura MacNeill, Ingrid Vallee, Sarah K. Schultz, Patrick O'Donoghue, Angelica A. Moresco, Victoria M. Siu, Ilka U. Heinemann   +9 more
wiley   +1 more source

Effect of intraoperative fluid optimisation on renal function in patients undergoing emergency abdominal surgery; a randomised controlled pilot study (ISRCTN 11799696) Fluid optimisation for emergency surgery [PDF]

, 2008
<b>Background:</b> Emergency abdominal surgery carries a high risk of postoperative morbidity and mortality. Goal directed therapy has been advocated to improve outcome in high-risk surgery.
McCreath, B., Kinsella, J., Hay, A., Harten, J., McMillan, D.C., McArdle, C.S., Crozier, J.E.M.   +6 more
core   +1 more source

A nationwide student survey on biochemistry learning resources in Italy

FEBS Open Bio, EarlyView.
We conducted a survey among Italian university students to investigate their preferred study materials for biochemistry. We then analyzed the collected data to identify these materials. This information may be valuable to the Biochemistry educational community. The graphical abstract was created with Claude (Opus 5.5; Anthropic, 2026).
Anna Marabotti, Ivano Eberini, Maria Luisa Genova, Francesca Mensitieri, Francesco Malatesta   +4 more
wiley   +1 more source

Interaction of goal-directed and pavlovian systems in aversive domains [PDF]

, 2011
Recent neuroscientific models of human behavior distinguish between different cognitive controllers: two instrumental systems (goal-directed and habitual) that maximize utility through learned actions, and a so-called Pavlovian system, which implements ...
Pavone, Enea Francesco, Rigoli, Francesco, Pezzulo, Giovanni   +2 more
core  

Goal-directed colloid administration improves the microcirculation of healthy and perianastomotic colon

, 2009
BACKGROUND: The aim of this study was to compare the effects of goal-directed colloid fluid therapy with goal-directed crystalloid and restricted crystalloid fluid therapy on healthy and perianastomotic colon tissue in a pig model of colon anastomosis ...
Hiltebrand, Luzius, Kimberger, Oliver, Arnberger, Michael, Brandt, Sebastian, Plock, Jan, Kurz, Andrea, Sigurdsson, Gisli H, Kimberger O, Plock J, Kurz A, Arnberger M, Brandt S, Sigurdsson GH, Hiltebrand L, Plock, Jan Alexander   +14 more
core   +1 more source

Five‐Year Outcomes of Laparoscopic Sphincter‐Preserving Surgery for Rectal Cancer: A Prospective Study in Elderly Vietnamese Patients

Aging and Cancer, EarlyView.
This prospective study demonstrates that laparoscopic sphincter‐preserving surgery is feasible for elderly patients. While overall survival reaches 70% at 5 years, advanced T‐stage and the omission of neoadjuvant therapy significantly drive recurrence, highlighting the need for personalized geriatric protocols despite logistical challenges.
Huu Duc Ho, Quang Le, Ngoc Thach Tran, Van Viet Ung, Loc Vu   +4 more
wiley   +1 more source

Perioperative Goal Directed Therapy (PGDT) [PDF]

, 2016
Banckground: Currently, there are trends to optimize hemodynamics during anesthesia with the specific goal, or called it “goal directed therapy”. Objective: Perioperative goal directed therapy (PGDT) has been proved to be beneficial to patients during ...
Pisitsak, Chawika
core   +1 more source