Results 81 to 90 of about 492,815 (298)

Parkinson's disease: autoimmunity and neuroinflammation [PDF]

, 2016
Parkinson's disease is a neurodegenerative disease that causes the death of dopaminergic neurons in the substantia nigra. The resulting dopamine deficiency in the basal ganglia leads to a movement disorder that is characterized by classical parkinsonian ...
CINIGLIO APPIANI, MARIO, CONTE, MICHELA, DE VINCENTIIS, Marco, DE VIRGILIO, ARMANDO, FABBRINI, Giovanni, GALLO, Andrea, GRECO, Antonio, INGHILLERI, Maurizio, RIZZO, MARIA IDA, ROSATO, CHIARA   +9 more
core   +1 more source

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

Aging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu, Latif Adams, Eunice Ampem‐Danso, Justice Kumi, Abigail Aning, Fatima Hamidu, Mustapha Abdul Mumin Mohammed, Ayuba Nii Darku Ankrah, Seth Kwabena Amponsah   +8 more
wiley   +1 more source

Initial Emergency Department Diagnosis and Management of Adult Patients with Severe Sepsis and Septic Shock

Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine, 2012
Severe sepsis is a medical emergency affecting up to 18 million individuals world wide, with an annual incidence of 750,000 in North America alone. Mortality ranges between 28-50% of those individuals stricken by severe sepsis.
Perman Sarah M, Goyal Munish, Gaieski David F   +2 more
doaj   +1 more source

Enhancing Nervous System Recovery through Neurobiologics, Neural Interface Training, and Neurorehabilitation. [PDF]

, 2016
After an initial period of recovery, human neurological injury has long been thought to be static. In order to improve quality of life for those suffering from stroke, spinal cord injury, or traumatic brain injury, researchers have been working to ...
Edgerton, V Reggie, Krucoff, Max O, Rahimpour, Shervin, Slutzky, Marc W, Turner, Dennis A   +4 more
core   +1 more source

Validity of a Wearable Digital Insole for Assessing Gait ON and OFF in Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Gait impairment is a distinctive symptom of Parkinson's disease that negatively impact mobility. We assessed the validity of wearable digital insoles against a validated reference gait analysis system for measuring select gait characteristics in patients with Parkinson's disease. Methods A comparative analysis between digital insoles
Deborah A. Hall, Kimberly Kwei, Rolando J. Acosta, Bharatkumar Koyani, Erin Robertson, Pratyush Rai, Roland Barge, Emily Timm, Nicollette L. Purcell, Natasha Desai, Dhanesh Patel, Ana‐Maria Visoiu‐Knapp, Samuel Stuart, Rinol Alaj, Matthew F. Wipperman, Oren Levy, Joan A. O'Keefe   +16 more
wiley   +1 more source

Sex Differences in Spatial Accuracy Relate to the Neural Activation of Antagonistic Muscles in Young Adults [PDF]

, 2017
Sex is an important physiological variable of behavior, but its effect on motor control remains poorly understood. Some evidence suggests that women exhibit greater variability during constant contractions and poorer accuracy during goal-directed tasks ...
Casamento-Moran, Agostina, Chen, Yen-Ting, Christou, Evangelos A., Fox, Emily J., Hunter, Sandra, Kwon, Min-Hyuk, Yacoubi, Basma   +6 more
core   +1 more source

Dynamic and volumetric variables reliably predict fluid responsiveness in a porcine model with pleural effusion [PDF]

, 2013
Background: The ability of stroke volume variation (SVV), pulse pressure variation (PPV) and global end-diastolic volume (GEDV) for prediction of fluid responsiveness in presence of pleural effusion is unknown.
A Kumar, A Peris, A Rhodes, Berthold Bein, Cordula M. Stover, D De Backer, D De Backer, D Osman, D Talmor, D Talmor, DA Reuter, E Azoulay, EE de Waal, F Michard, F Michard, G Dechman, J Graf, J Mayer, J Renner, J Renner, J Sagrista-Sauleda, Jan Schöttler, Jochen Renner, K Vaska, Katharina Heß, M Balik, M Cannesson, M Cannesson, M Hadian, Markus Steinfath, Matthias Gruenewald, MR Lopes, MR Pinsky, O Broch, O Nishida, Ole Broch, P Pelosi, Patrick Meybohm, PE Marik, R Jacob, R Pearse, RJ Trof, S Heenen, S Magder, S Rex, S Rex, SG Sakka, SH Loring   +47 more
core   +2 more sources

Goal-directed Therapy [PDF]

Anesthesiology, 2020
Kamal, Maheshwari, Daniel I, Sessler
openaire   +2 more sources

Sex Representation in US Stroke Clinical Trials: A Decade of Trends and Challenges

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Stroke remains a major cause of disability and mortality in the US, with significant sex‐based disparities, and females remain underrepresented in stroke clinical trials. We aimed to examine sex representation in US‐based stroke clinical trials, identify trial characteristics associated with higher female enrollment (≥ 50%), and ...
Chaitali Dagli, Mudasir Andrabi, Tova Cohen, Pranali G. Patel, Tapasya Katta, Chen Lin   +5 more
wiley   +1 more source

The magnetofection method: Using magnetic force to enhance gene delivery [PDF]

, 2003
In order to enhance and target gene delivery we have previously established a novel method, termed magnetofection, which uses magnetic force acting on gene vectors that are associated with magnetic particles.
Alexiou C., Beason R., Chen C. A., Fischer A., Grimm S., Kass-Eisler A., Lübbe A. S., Lübbe A. S., Meyer K. B., Plank C., Weissleder R.   +10 more
core   +4 more sources