Results 51 to 60 of about 140,487 (297)
A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner
Molecular Oncology, EarlyView.We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp +13 more
wiley +1 more source
Indian Journal of Animal Sciences, 2016 Male Barbari kids (56), 7 to 8 months of age and weighing19.2± 2.9 kg were randomly divided into 4 equal groups to assess the effect of source (inorganic or organic) and level of Zn, Cu, Co and Mn on intake and growth performance.
U B CHAUDHARY +5 more
doaj +1 more source
Role of certain growth factors and hormones in folliculogenesis
Indian Journal of Animal Sciences, 2020 Folliculogenesis is an inextricable process associated with female fertility and infertility cases. This process involves many events at cellular and molecular level in a highly orchestrated fashion which culminates with ovulation.
SURESH DINKAR KHARCHE +4 more
doaj +1 more source
Molecular Oncology, EarlyView.Overexpression of CHRDL2 in colon cancer cells makes them more stem‐like and resistant to chemo‐ and radiotherapy. CHRDL2‐high cells have upregulation of the WNT pathway, genes involved in the DNA damage response (DDR) pathway and epithelial‐to‐mesenchymal transition (EMT). This leads to quicker repair of damaged DNA and more cell migration.
Eloise Clarkson, Annabelle Lewis
wiley +1 more source
InDel and CNV within the AKAP13 Gene Revealing Strong Associations with Growth Traits in Goat
Animals, 2023 A-kinase-anchoring protein 13 (AKAP13) is a member of the AKAP protein family that has been found to be associated with bone formation. Thus, we investigated the AKAP13 gene as a potential candidate gene for molecular-marker-assisted selection (MAS) in ...
Xiaoyue Song +5 more
doaj +1 more source
EMT‐associated bias in the Parsortix® system observed with pancreatic cancer cell lines
Molecular Oncology, EarlyView.The Parsortix® system was tested for CTC enrichment using pancreatic cancer cell lines with different EMT phenotypes. Spike‐in experiments showed lower recovery of mesenchymal‐like cells. This was confirmed with an EMT‐inducible breast cancer cell line.
Nele Vandenbussche +8 more
wiley +1 more source
Influence of floor type on production performance and worm load in lactating Jakhrana goats
Indian Journal of Animal Sciences, 2019 The aim of this study was to investigate the effect of slatted floor (SLF) over soil floor (SOF) on performance of lactating goats reared under group feeding conditions up to 120 days postpartum. Fortnightly live weight and weekly test day milk yield was
N RAMACHANDRAN +6 more
doaj +1 more source
In silico to In vivo development of a polyherbal against Haemonchus contortus
Heliyon, 2022 Haemonchus contortus is a major constraint in the development of small ruminant subsector due to significant production losses incurred by it. The present study explores the antiparasitic potential of three anthelmintic plants (Butea monosperma, Vitex ...
Anu Rahal +4 more
doaj +1 more source
Molecular Oncology, EarlyView.Cotargeting EGFR and STAT3 with Erlotinib and TTI‐101 impairs both 2D and 3D growth of ETV1‐overexpressing prostate cancer cells by disrupting a self‐sustaining ETV1–EGFR positive feedback loop that promotes EGFR and STAT3 expression and phosphorylation (activation).
Elsa Gomes Paiva +5 more
wiley +1 more source
Molecular Oncology, EarlyView.Human cytomegalovirus infection is common in normal prostate epithelium, prostate tumor tissue, and prostate cancer cell lines. CMV promotes cell survival, proliferation, and androgen receptor signaling. Anti‐CMV pharmaceutical compounds in clinical use inhibited cell expansion in prostate cancer models in vitro and in vivo, motivating investigation ...
Johanna Classon +13 more
wiley +1 more source