Results 71 to 80 of about 212,535 (287)

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Understanding the skin blackening phenomenon in Youzhou Dark goats based on the histological characteristics of melanocytes

Journal of Advanced Veterinary and Animal Research
Objective: The study was conducted to identify the molecular mechanism of the phenotype formation of Youzhou black sheep by histological cytology and transcriptomics.
Cancan Chen, Jie Li, Xiaoyan Sun, Jing Jiang, Shipeng Lv, Liangjia Liu, Gaofu Wang, Hangxing Ren   +7 more
doaj   +1 more source

Design and Characterization of a 52K SNP Chip for Goats

PLoS ONE, 2014
The success of Genome Wide Association Studies in the discovery of sequence variation linked to complex traits in humans has increased interest in high throughput SNP genotyping assays in livestock species.
G. Tosser-Klopp, P. Bardou, O. Bouchez, Cédric Cabau, R. Crooijmans, Yang Dong, Cécile Donnadieu-Tonon, A. Eggen, H. Heuven, Saadiah Jamli, A. J. Jiken, C. Klopp, C. Lawley, J. McEwan, Patrice Martin, Carole R Moreno, P. Mulsant, Ibouniyamine Nabihoudine, E. Pailhoux, I. Palhière, R. Rupp, J. Sarry, B. Sayre, A. Tircazes, Jun Wang, Wen Wang, Wenguang Zhang   +26 more
semanticscholar   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

Screening of Deletion Variants within the Goat PRDM6 Gene and Its Effects on Growth Traits

Animals, 2020
By genome-wide association studies, the PRDM6 gene has been shown to affect multiple, apparently unrelated inherited traits, including bone density and body mass index. Therefore, it is considered a potentially pleiotropic gene.
Zhen Wang, Congliang Wang, Yongni Guo, Shuaishuai She, Baojing Wang, Yuru Jiang, Yangyang Bai, Xiaoyue Song, Longping Li, Lei Shi, Lei Qu, Xianyong Lan, Haijing Zhu   +12 more
doaj   +1 more source

Efficient Gene Knockout in Goats Using CRISPR/Cas9 System

PLoS ONE, 2014
The CRISPR/Cas9 system has been adapted as an efficient genome editing tool in laboratory animals such as mice, rats, zebrafish and pigs. Here, we report that CRISPR/Cas9 mediated approach can efficiently induce monoallelic and biallelic gene knockout in
Wei Ni, J. Qiao, Sheng-Zhou Hu, Xinxia Zhao, M. Regouski, M. Yang, I. Polejaeva, Chuangfu Chen   +7 more
semanticscholar   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

TMC4 localizes to multiple taste cell types in the mouse taste papillae

FEBS Open Bio, EarlyView.
Transmembrane channel‐like 4 (TMC4), a voltage‐dependent chloride channel, plays a critical role in amiloride‐insensitive salty taste transduction. TMC4 is broadly expressed in all mature taste cell types, suggesting a possible involvement of multiple cell types in this pathway.
Momo Murata, Yoshikazu Saito, Yoichi Kasahara, Wataru Fujii, Takumi Misaka, Tomiko Asakura, Masataka Narukawa   +6 more
wiley   +1 more source

Multiplier flock scheme in Barbari goats: An entrepreneurship model for in situ breed conservation and improvement

Indian Journal of Animal Sciences
Barbari is a most preferred breed for commercial goat farming-under intensive management. However, pure-bred Barbari goats; especially buck’s availability are meager due to indiscriminate castration which resulted in stagnation of genetic improvement ...
M K SINGH, R POUROUCHOTTAMANE, AKHILESH KUMAR, S P SINGH, RAVI RANJAN, A K DIXIT, NITIKA SHARMA, RAVINDRA KUMAR   +7 more
doaj   +1 more source