Results 71 to 80 of about 392,022 (297)
Molecular Oncology, EarlyView.Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz +15 more
wiley +1 more source
Journal of Advanced Veterinary and Animal ResearchObjective: The study was conducted to identify the molecular mechanism of the phenotype formation of Youzhou black sheep by histological cytology and transcriptomics.
Cancan Chen +7 more
doaj +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Effects of sainfoin hay on gastrointestinal infection with nematodes in goats [PDF]
, 2003 EFFECTS OF SAINFOIN HAY ON GASTROINTESTINAL INFECTION WITH NEMATODES IN ...
H., HOSTE, Ph., DORCHIES, V., PAOLINI
core
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Screening of Deletion Variants within the Goat PRDM6 Gene and Its Effects on Growth Traits
Animals, 2020 By genome-wide association studies, the PRDM6 gene has been shown to affect multiple, apparently unrelated inherited traits, including bone density and body mass index. Therefore, it is considered a potentially pleiotropic gene.
Zhen Wang +12 more
doaj +1 more source
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Effect of azolla supplementation in feed on semen freezability in bucks
Indian Journal of Animal Sciences, 2019 The present study was conducted to evaluate the effect of azolla supplementation on semen freezability in Barbari bucks. Ten adult Barbari bucks (2–4 years old) were selected, and divided into control and treatment group (5 bucks in each group) as per ...
CHETNA GANGWAR +5 more
doaj +1 more source
Comparative performance of Barbari goats under different rearing system in semi-arid region
Indian Journal of Animal Sciences, 2020 This study was undertaken to compare the performance of Barbari goats under grazing system and stall feeding system. Thirty growing Barbari goats of average body weight 15.20±0.54 kg of about 6 months of age were divided into three equal groups (Gr 1 ...
M K SINGH, RAVINDRA KUMAR, S P SINGH
doaj +1 more source
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source