Cellular and Molecular Gastroenterology and Hepatology, 2021 Background & Aims: Cell differentiation in the colonic crypt is driven by a metabolic switch from glycolysis to mitochondrial oxidation. Mitochondrial and goblet cell dysfunction have been attributed to the pathology of ulcerative colitis (UC).
Annika Sünderhauf +16 more
doaj +1 more source
Disease-specific transcriptional programs govern airway goblet cell metaplasia
HeliyonHypersecretion of airway mucus caused by goblet cell metaplasia is a characteristic of chronic pulmonary inflammatory diseases including asthma, cystic fibrosis (CF), and chronic obstructive pulmonary disease (COPD).
Kuan Li +6 more
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ISOLATION OF STEM CELLS FROM THE MID GUT EPITHELIUM OF CULEX PIPIENS MOSQUITOES (DIPTERA: CULICIDAE) [PDF]
Journal of the Egyptian Society of Parasitology, 2014 Stem cells are undifferentiated cells that remarkable ability to self-renew and produce differentiated cells that support normal development and tissue homeostasis.
H. METWALY +3 more
doaj +1 more source
Morphology of Intestinal Goblet Cells of The Dromedary (Camelus dromedarius)
, 2019 Morphology of the goblet cells in the intestine of the dromedary (Camelus dromedarius ) was carried out by light and electron microscopes. Histologically, the goblet cells appeared as globular or ovoidshaped with basally located flat nuclei.
Mohamed, AMA, Ali, AM, Taha, AAM
core +2 more sources
Epithelial GPR35 protects from Citrobacter rodentium infection by preserving goblet cells and mucosal barrier integrity [PDF]
, 2022 Goblet cells secrete mucin to create a protective mucus layer against invasive bacterial infection and are therefore essential for maintaining intestinal health.
Flint, Emilio +14 more
core +1 more source
Epidermal Growth Factor Removal or Tyrphostin AG1478 Treatment Reduces Goblet Cells & Mucus Secretion of Epithelial Cells from Asthmatic Children Using the Air-Liquid Interface Model. [PDF]
PLoS ONE, 2015 Epithelial remodelling in asthma is characterised by goblet cell hyperplasia and mucus hypersecretion for which no therapies exist. Differentiated bronchial air-liquid interface cultures from asthmatic children display high goblet cell numbers. Epidermal
Jeremy C Parker +7 more
doaj +1 more source
Is the Intestinal Goblet Cell a Major Immune Cell? [PDF]
Cell Host & Microbe, 2014 Recent reports indicate that both the inflammasome (Wlodarska et al., 2014) and autophagy (Patel et al., 2013) pathways in goblet cells control mucin secretion, defects in which are linked to difficulties in clearing pathogenic bacteria and maintaining intestinal homeostasis and control colitis.
Johansson, Malin E.V. +1 more
openaire +2 more sources
PLoS ONE, 2019 To use human limbal explants as an alternative source for generating conjunctival epithelium and to determine the effect of interleukin-13 (IL-13) on goblet cell number, mucin expression, and stemness. Human limbal explants prepared from 17 corneoscleral
Andrea Stadnikova +4 more
doaj +1 more source
Staphylococcus aureus activates the NLRP3 inflammasome in human and rat conjunctival goblet cells.
PLoS ONE, 2013 The conjunctiva is a moist mucosal membrane that is constantly exposed to an array of potential pathogens and triggers of inflammation. The NACHT, leucine rich repeat (LRR), and pyrin domain-containing protein 3 (NLRP3) is a Nod-like receptor that can ...
Victoria E McGilligan +7 more
doaj +1 more source
IFNγ reduces viability in human conjunctival goblet cells in vitro
, 2022 PurposeConjunctival goblets cells play an important role in the homeostasis of the ocular surface and are known to be affected by inflammatory cytokines in diseases of the ocular surface.
Miriam Kolko +9 more
core +1 more source