Results 21 to 30 of about 1,099,253 (266)

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Ligamentous Injuries in Stable Ankle Fractures: An MRI-Based Study

Foot & Ankle Orthopaedics
Background: Ankle fractures are common orthopaedic injuries, and their management is primarily determined by fracture stability. The Lauge-Hansen classification system categorizes fractures according to mechanism of injury and ligaments involved ...
Alex N. Karanja MBChB, Albert Ho-Huynh MBBS, Tom Walsh PhD, Simon R. Platt MBChB, FRCS, FRACS, FAOrthoA   +3 more
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Altered JS‐2 expression in colorectal cancers and its clinical pathological relevance

Molecular Oncology, 2011
JS‐2 is a novel gene located at 5p15.2 and originally detected in primary oesophageal cancer. There is no study on the role of JS‐2 in colorectal cancer.
Alfred King-Yin Lam, Vinod Gopalan, Mohammad Reza Nassiri, Kais Kasim, Jayampathy Dissanayake, Johnny Chuek-On Tang, Robert Anthony Smith   +6 more
doaj   +1 more source

Layout and Parameter Analysis of the Cooling System with Mine Water as Cold Source in Linglong Gold Mine

Geofluids, 2023
As the heat hazard problem in the deep mine becomes more prominent, it is difficult to alleviate the high-temperature problem by increasing the air supply and adjusting the ventilation mode alone.
Chunlong Wang, Hongkai Zhao, Li Cheng, Guilin Li, Yuyun Fan, Mingwei Jiang, Yingjie Hao, Kun Shao   +7 more
doaj   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Overcoming barriers and enabling artificial intelligence adoption in allied health clinical practice: A qualitative study

Digital Health
Background Artificial intelligence (AI) has the potential to revolutionise healthcare. If the implementation is successful it has the potential to improve healthcare outcomes for patients and organisations. Little is known about the perceptions of allied
Jane Hoffman, Rachel Wenke, Rebecca L Angus, Lucy Shinners, Brent Richards, Laetitia Hattingh   +5 more
doaj   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Long term outcomes of open reduction internal fixation versus external fixation of distal radius fractures: A meta-analysis

Orthopedic Reviews, 2019
Distal radius fractures are among the most common fractures encountered in the clinical setting. Of these common fractures, it has been said that up to 60% are intraarticular in nature.
Conor Gouk, Shu-Kay Ng, Matthew Knight, Randy Bindra, Michael Thomas   +4 more
doaj   +1 more source