Results 51 to 60 of about 249,130 (199)

Myelotoxicity of gold. [PDF]

BMJ, 1976
Of 55 patients who developed blood dyscrasias attributable to gold treatment 15 with bone marrow hypoplasia died. A few of the dyscrasias, occurring in patients who had taken a low total dose of sodium aurothiomalate, may have resulted from immune hypersensitivity, but most, occurring in patients who had taken a higher total dose, were due to ...
openaire   +3 more sources

On subcellular distribution of the zinc finger 469 protein (ZNF469) and observed discrepancy in the localization of endogenous and overexpressed ZNF469

FEBS Open Bio, EarlyView.
ZNF469 regulates the expression of genes encoding extracellular matrix proteins. Endogenous ZNF469 is predominantly cytoplasmic, while in transfected cells, it forms aggregates reminiscent of biomolecular condensates, located mainly in the nucleus. These condensates exhibit overlapping staining with proteasomes and are also associated with the mitotic ...
Anne Elisabeth Christensen Mellgren, Ileana Cristea, Thomas Stevenson, Endy Spriet, Per Morten Knappskog, Stig Ove Bøe, Harald Kranz, Sushma N. Grellscheid, Eyvind Rødahl   +8 more
wiley   +1 more source

Five‐year evaluation of linear accelerator‐based SRS platform isocentricity

Journal of Applied Clinical Medical Physics, EarlyView.
Abstract Linear accelerator (LINAC)‐based stereotactic radiosurgery (SRS) has become a mainstay in the management of intracranial tumors. However, the high fractional doses and sharp gradients used in SRS place heavy demands on geometric accuracy.
Yohan A. Walter, Anne N. Hubbard, Phillip F. Durham, Hsinshun T. Wu   +3 more
wiley   +1 more source

Online correction of intrafraction motion during volumetric modulated arc therapy for prostate radiotherapy using fiducial‐based kV imaging: A cohort study quantifying the frequency of shifts and analysis of men at highest risk

Journal of Applied Clinical Medical Physics, EarlyView.
Abstract Background Various methods exist to correct for intrafraction motion (IFM) of the prostate during radiotherapy. We sought to characterize setup corrections in our practice informed by the TrueBeam Advanced imaging package, and analyze factors associated with IFM.
Lucas M. Serra, Tianming Wu, Mark C. Korpics, Kamil Yenice, Stanley L. Liauw   +4 more
wiley   +1 more source

Development of an automated CBCT‐based simulation‐free platform for expedited palliative radiotherapy on a conventional linear accelerator

Journal of Applied Clinical Medical Physics, EarlyView.
Abstract Background Conventional approaches for emergent or expedited palliative radiotherapy (RT) involve the application of cumbersome vendor‐provided solutions and/or multiple patient appointments to complete the RT workflow within a compressed timeframe.
Riley C. Tegtmeier, Edward L. Clouser Jr., Quan Chen, Courtney R. Buckey, Suzanne J. Chungbin, Christopher J. Kutyreff, Jose S. Aguilar, Amber L. Labbe, Brooke L. Horning, William G. Rule, Sujay A. Vora, Yi Rong   +11 more
wiley   +1 more source

Improving VMAT dose calculation accuracy and planning quality via a GPU‐accelerated Fourier transform dose calculation algorithm

Journal of Applied Clinical Medical Physics, EarlyView.
Abstract Background Inverse planning typically utilizes fast, less accurate dose calculation algorithms during the iterative optimization process, thus leading to dose calculation errors (DCEs) and suboptimal plans that often require dose normalization and/or plan re‐optimization.
Kenny Guida, Chaoqiong Ma, Joy Patel, Krishna Reddy, H. Harold Li   +4 more
wiley   +1 more source

Effects of cardiac motion on dose distribution during stereotactic arrhythmia radioablation treatment: A simulation and phantom study

Journal of Applied Clinical Medical Physics, EarlyView.
Abstract Purpose Cardiac motion may degrade dose distribution during stereotactic arrhythmia radioablation using the CyberKnife system, a robotic radiosurgery system. This study evaluated the dose distribution changes using a self‐made cardiac dynamic platform that mimics cardiac motion. Methods The cardiac dynamic platform was operated with amplitudes
Takayuki Miyachi, Takeshi Kamomae, Fumitaka Kawabata, Kuniyasu Okudaira, Mariko Kawamura, Shunichi Ishihara, Shinji Naganawa   +6 more
wiley   +1 more source

T2‐weighted imaging of rectal cancer using a 3D fast spin echo sequence with and without deep learning reconstruction: A reader study

Journal of Applied Clinical Medical Physics, EarlyView.
Abstract Purpose To compare image quality and clinical utility of a T2‐weighted (T2W) 3‐dimensional (3D) fast spin echo (FSE) sequence using deep learning reconstruction (DLR) versus conventional reconstruction for rectal magnetic resonance imaging (MRI).
Dan Nguyen, Sarah Palmquist, Ken‐Pin Hwang, Jingfei Ma, Usama Salem, Jia Sun, Xinzeng Wang, Jong Bum Son, Randy Ernst, Peng Wei, Harmeet Kaur, Nir Stanietzky   +11 more
wiley   +1 more source

Modelling of a double‐scattering proton therapy nozzle using the FLUKA Monte Carlo code and analysis of linear energy transfer in patients treated for prostate cancer

Journal of Applied Clinical Medical Physics, EarlyView.
Abstract Background The dose‐averaged linear energy transfer (LETD) in proton therapy (PT) has in pre‐clinical studies been linked to the relative biological effectiveness (RBE) of protons. Until recently, the most common PT delivery method in prostate cancer has been double‐scattered PT, with LETD only available through dedicated Monte Carlo (MC ...
Rasmus Klitgaard, Lars Fredrik Fjæra, Camilla Hanquist Stokkevåg, Perry Johnson, Mark Artz, Nancy Price Mendenhall, Curtis Bryant, Ludvig Paul Muren   +7 more
wiley   +1 more source

A review of artificial intelligence in brachytherapy

Journal of Applied Clinical Medical Physics, EarlyView.
Abstract Artificial intelligence (AI) has the potential to revolutionize brachytherapy's clinical workflow. This review comprehensively examines the application of AI, focusing on machine learning and deep learning, in various aspects of brachytherapy.
Jingchu Chen, Richard L. J. Qiu, Tonghe Wang, Shadab Momin, Xiaofeng Yang   +4 more
wiley   +1 more source