Results 61 to 70 of about 62,853 (255)

Gold-catalyzed propargylic substitutions: Scope and synthetic developments

Beilstein Journal of Organic Chemistry, 2011
This personal account summarizes our recent developments in gold-catalyzed direct substitutions on propargylic (allylic, benzylic) alcohols, with various nucleophiles (and bi-nucleophiles) based on the σ- and/or π-acidity of gold(III) complexes ...
Olivier Debleds, Eric Gayon, Emmanuel Vrancken, Jean-Marc Campagne   +3 more
doaj   +1 more source

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source

SPECTRAL AND THERMAL STUDIES ON SOME SACCHARINATO COMPLEXES

Zagazig Journal of Pharmaceutical Sciences, 2003
The saccharinato complexes of Au(III). ZrO(II), VO (I) and UO2(II) metal ions have been prepared and the mode of coordination of saccharin in these complexes has been investigated through their 1HNMR and IR spectra as well as by thermal analysis.
Said Teleb
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Computational Study of the Photophysical Properties and Electronic Structure of Gold (III) Complexes with Different Groups

ChemistryOpen
A series of novel delayed phosphorescent gold(III) complexes, Au(EDG)(EAG) (where EDG = electron‐donating group and EAG = electron‐accepting group), have been reported, exhibiting stable and high‐performance luminescence. The thermally stimulated delayed
Caijie Bu, Tao Yuan, Han Xiao, Jing Wei, Minyi Zhang   +4 more
doaj   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Anticancer and Antibacterial Activity Studies of Gold(I)-Alkynyl Chromones

Molecules, 2015
Three gold(I) complexes of alkynyl chromones were synthesized and characterized. The single-crystal X-ray structure analysis of a dinuclear compound and of a flavone derivative exhibit a typical d10 gold(I)-alkynyl linear arrangement.
Paweł Hikisz, Łukasz Szczupak, Aneta Koceva-Chyła, Adam Gu´spiel, Luciano Oehninger, Ingo Ott, Bruno Therrien, Jolanta Solecka, Konrad Kowalski   +8 more
doaj   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Investigation of the Complexation Activity of 2,4-Dithiouracil with Au(III) and Cu(II) and Biological Activity of the Newly Formed Complexes

Applied Sciences
The goal of this study is to synthesize, determine the structure, and examine the antimicrobial properties of novel Cu(II) and Au(III) complexes of 2,4-dithiouracil and its derivatives.
Petya Marinova, Dimitar Stoitsov, Nikola Burdzhiev, Slava Tsoneva, Denica Blazheva, Aleksandar Slavchev, Evelina Varbanova, Plamen Penchev   +7 more
doaj   +1 more source