Results 91 to 100 of about 956,222 (367)
Quantitative analysis of intra-Golgi transport reveals inter-cisternal exchange for all cargo [PDF]
, 2013 The mechanisms controlling the transport of proteins across the Golgi stack of mammalian and plant cells is the subject of intense debate, with two models, cisternal progression and inter-cisternal exchange, emerging as major contenders. A variety of transport experiments have claimed support for each of these models.
arxiv +1 more source
Stacks on tracks: the plant Golgi apparatus traffics on an actin/ER network.
The Plant Journal, 1998 We have visualized the relationship between the endoplasmic reticulum (ER) and Golgi in leaf cells of Nicotiana clevelandii by expression of two Golgi proteins fused to green fluorescent protein (GFP).
P. Boevink +5 more
semanticscholar +1 more source
Advanced Science, EarlyView.NRAS mutations are widespread in hematologic malignancies. Our study shows that GOLGA7 serves as a safe and effective therapeutic target for NRAS‐driven leukemia. Loss of Golga7 in adult mice effectively suppresses NrasG12D‐driven myeloproliferative neoplasm by disrupting its PM localization and impairing subsequent MAPK signaling, without affecting ...
Bo Jiao +18 more
wiley +1 more source
Brain Pathology, Volume 33, Issue 1, January 2023., 2023 Schematic depicting mechanism by which HPC protects neurons against tGCI in CA1 through Piwil2‐mediated epigenetics. Abstract Epigenetic modification contributes to the pathogenesis of cerebral ischemia. Piwil2 belongs to the PIWI proteins subfamily and has a key role in the regulation of gene transcription through epigenetics.
Lixuan Zhan +8 more
wiley +1 more source
Bio-Protocol, 2015 The plant Golgi apparatus is composed of numerous stacks of cisterna, designated as cis, medial, and trans Golgi cisternae; these stacks move within the cytoplasm along the actin cytoskeleton.
Satoshi Naramoto +2 more
doaj +1 more source
Structural organization of the Golgi apparatus [PDF]
Current Opinion in Cell Biology, 2011 The Golgi apparatus is a universal feature of eukaryotes, carrying out the key functions of processing, sorting and trafficking of newly synthesized membrane and secretory proteins. The Golgi apparatus has a clearly defined structure, comprising stacks of flattened cisternal membranes that in vertebrates are connected to form a ribbon.
openaire +3 more sources
Advanced Science, EarlyView.TRIM25‐mediated ubiquitination of INSIG1 serves as a key driver of lipid metabolism dysregulation in MASH progression. It identifies a novel small‐molecule inhibitor, C27H26N2O4S, which effectively inhibits TRIM25 activity, reducing lipid accumulation and inflammation.
Hao Zhang +8 more
wiley +1 more source
Urothelial plaque formation in post-Golgi compartments. [PDF]
PLoS ONE, 2011 Urothelial plaques are specialized membrane domains in urothelial superficial (umbrella) cells, composed of highly ordered uroplakin particles. We investigated membrane compartments involved in the formation of urothelial plaques in mouse umbrella cells.
Samo Hudoklin +4 more
doaj +1 more source
Vessel‐On‐A‐Chip Coupled Proteomics Reveal Pressure‐Overload‐Induced Vascular Remodeling
Advanced Science, EarlyView.A vessel‐on‐a‐chip system is developed to replicate both physiological and pathological vessel cyclic stretches. Proteomic analysis reveals pressure‐overload‐induced vascular remodeling, including cellular response to mechanical cues, cellular oxidative stresses, ER stress, and ceramide biosynthesis activation in the vessel‐on‐a‐chip system, well ...
Yanjun Liu +11 more
wiley +1 more source
The Golgin Family of Coiled-Coil Tethering Proteins
Frontiers in Cell and Developmental Biology, 2016 The golgins are a family of predominantly coiled-coil proteins that are localized to the Golgi apparatus. Golgins are present in all eukaryotes, suggesting an evolutionary conserved function.
Tomasz M Witkos, Martin eLowe
doaj +1 more source