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Gonadal tumor development in 46,XX disorders of gonadal development [PDF]
European Journal of Endocrinology, 2022 Background Differences/disorders of sex development (DSD) are congenital conditions in which the development of chromosomal, gonadal, or anatomical sex is atypical. Objective The aim of this study is to report the histological characteristics and immunoexpression patterns of gonadal parenchyma in patients with 46,XX testicular and ovotesticular DSD,
Mariana Costanzo +12 more
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Sex Determination and Gonadal Development in Mammals [PDF]
Physiological Reviews, 2007 Arguably the most defining moment in our lives is fertilization, the point at which we inherit either an X or a Y chromosome from our father. The profoundly different journeys of male and female life are thus decided by a genetic coin toss. These differences begin to unfold during fetal development, when the Y-chromosomal Sry (“sex-determining region Y”
Wilhelm, D., Palmer, S., Koopman, P.
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Sex Determination and Gonadal Development [PDF]
, 2010 In mammals, sex determination is a result of chromosomal constitution determined at fertilization, with females harboring XX and males XY sex chromosomes. The apparent simplicity of this system belies the intricate genetic and cellular interactions that direct differentiation of the bipotential gonadal primordium into either a testis or an ovary. These
Combes, Alexander +2 more
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Disorders of Gonadal Development
Seminars in Reproductive Medicine, 2002The molecular mechanisms of gonadal development are a complex process, which involves the tightly regulated differentiation of a bipotential embryonic gonad into either testes or ovary. Once this has occurred, the phenotypic and gonadal sex of an individual has been genetically determined. This process, however, may not always be so straightforward. By
Phoebe, Dewing +2 more
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Signaling at the crossroads of gonad development
Trends in Endocrinology and Metabolism, 2005In mammals, the gonads arise as bipotential primordia that are capable of developing as either testes or ovaries. Expression of the Y-linked gene Sry in the XY gonad initiates testis differentiation; in the absence of Sry, ovarian pathways prevail. Although the molecular targets of SRY are not known, many of the early cellular and morphological events ...
Andrea J, Ross, Blanche, Capel
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2014
The commitment of the embryonic gonad towards the male or female fate is a sequential and complex developmental process. The sex-independent growth and development of the adrenogonadal primordium into the bipotential gonadal ridge is committed to the formation of testis in the presence of the SRY gene on the Y chromosome. SRY upregulates the expression
Angela K, Lucas-Herald, Anu, Bashamboo
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The commitment of the embryonic gonad towards the male or female fate is a sequential and complex developmental process. The sex-independent growth and development of the adrenogonadal primordium into the bipotential gonadal ridge is committed to the formation of testis in the presence of the SRY gene on the Y chromosome. SRY upregulates the expression
Angela K, Lucas-Herald, Anu, Bashamboo
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GENE INTERACTIONS IN GONADAL DEVELOPMENT
Annual Review of Physiology, 1999▪ Abstract The acquisition of a sexually dimorphic phenotype is a critical event in mammalian development. Although the maturation of sexual function and reproduction occurs after birth, essentially all of the critical developmental steps take place during embryogenesis.
Parker KL, Schedl A, Schimmer BP
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Intrauterine Gonadal Development
Fertility and Sterility, 1976This review article summarizes the intrauterine gonadal development and differentiation of both male and female human embryos and fetuses. It describes in detail (1) the organization of the indifferent gonad and its seeding by the extra-gonadal germ cells, (2) the development of the duct systems before sex differentiation, and (3) the controlling ...
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Gonadal development in hermaphrodite mice
In Vitro, 1979The genetic background and morphology of spontaneous mosaic hermaphrodites of mice have been described.
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