Results 251 to 260 of about 70,106 (300)

Sexual dimorphism of gonadal development

Best Practice & Research Clinical Endocrinology & Metabolism, 2007
Sexual dimorphism is a term describing morphological differences between the sexes, but is often extended to include all differences observed between females and males. Sex differentiation in vertebrates is by definition sexually dimorphic and starts at the level of the sex chromosomes. In this review the sexual dimorphism of gonadal differentiation is
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WNT4 Signaling in Female Gonadal Development

Endocrine, Metabolic & Immune Disorders - Drug Targets, 2010
WNT4 signaling pathways represent an important step in the multi-faceted process of mammalian gonadal differentiation and the development of internal genitalia. WNT4 protein controls the cytoplasmatic stability of specific transcriptional coactivator beta catenin during both embriogenesis and adult homeostasis.
Miriam, Pellegrino, Raffaella, Maiorino, Sergio, Schonauer   +2 more
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Methods for the Study of Gonadal Development

2016
Current knowledge on gonadal development and sex determination is the product of many decades of research involving a variety of scientific methods from different biological disciplines such as histology, genetics, biochemistry, and molecular biology.
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Development of the Male Gonad

2017
Normal sexual development Gonads and sex differentiation Testicular descent Stages of errors in ...
Shilpa Sharma, Anand Kumar, Devendra K. Gupta   +2 more
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Role of Ahch in gonadal development and gametogenesis

Nature Genetics, 1998
Ahch (also known as Dax1) encodes a transcription factor that has been implicated in sex determination and gonadal differentiation. Mutations in human AHC cause X-linked, adrenal hypoplasia congenita (AHC) and hypogonadotropic hypogonadism (HH). Duplication of the Xp21 dosage-sensitive sex reversal (DSS) region, which contains the Ahch locus, and ...
R N, Yu, M, Ito, T L, Saunders, S A, Camper, J L, Jameson   +4 more
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Sphingolipid signaling in gonadal development and function

Chemistry and Physics of Lipids, 1999
Sphingolipid second messengers, such as ceramide and sphingosine-1-phosphate, signal proliferation, differentiation and death in mammalian cells. The object of this article is to highlight the potential impact of this new information on the study of female and male gonadal development and function.
J L, Tilly, R N, Kolesnick
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Gonadal Hormones and the Developing Brain

1974
Research during the past 15 years has revealed that the developing brain has a sensitivity and response to gonadal hormones which differs from that of the fully mature brain. This age-dependent sensitivity of brain to hormones has been shown in studies of the ontogeny of gonadal function as well as in studies of the development of behavior. Research in
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E-cadherin in the developing mouse gonad

Anatomy and Embryology, 1999
Expression of the cell adhesion molecule E-cadherin in the developing mouse has been investigated by immunocytochemistry and disaggregated organ culture. The principal aims were firstly, to determine whether E-cadherin is expressed in the indifferent gonad and if so with which cell population(s) it is associated. Secondly, to investigate the pattern of
S, Mackay, C L, Nicholson, S P, Lewis, M, Brittan   +3 more
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Genetic regulation of mammalian gonad development

Nature Reviews Endocrinology, 2014
Sex-specific gonadal development starts with formation of the bipotential gonad, which then differentiates into either a mature testis or an ovary. This process is dependent on activation of either the testis-specific or the ovary-specific pathway while the opposite pathway is continuously repressed. A network of transcription factors tightly regulates
Stefanie, Eggers, Thomas, Ohnesorg, Andrew, Sinclair   +2 more
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DISORDERS OF GONADAL DEVELOPMENT

Pediatrics, 1973
In 1947, Professor Alfred Jost completed a series of classical experiments with the fetal rabbit from which it was shown that early castration in utero resulted in phenotypic femaleness, regardless of genetic sex.1 These observations indicated that masculine differentiation of the internal ducts and of the primordia from which the external genitalia ...
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