Results 51 to 60 of about 74,557 (274)

Growth Hormone Treatment in Patients With KBG Syndrome: Novel Insights, Challenges and Recommendations From Six New Patients and Literature Review

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT KBG syndrome is one of the most frequent neurodevelopmental disorders and is caused by ANKRD11 variants. Postnatal short stature is observed in ~50% of patients. Recombinant human growth hormone (rhGH) has become a valuable treatment for patients with growth hormone deficiency (GHD) along with Prader–Willi and Turner syndrome. Limited evidence
Sietse M. Aukema, Kim Vandenput, Emanuela Scarano, Himanshu Goel, Lily Guo, Michiel Vanneste, Koen Devriendt, Nitash Zwaveling‐Soonawala, Cordula Kiewert, Alma Kuechler, Ilaria Parenti, Eleonora Orlandini, Elke de Boer, Siddharth Banka, Elizabeth Wall, Gholson J. Lyon, Karen J. Low, Joyce M. Geelen, Yvonne G. van der Zwan, Charlotte W. Ockeloen   +19 more
wiley   +1 more source

Emerging Perspectives on Gonadotropin Regulation in Vertebrates Revealed by the Discovery of FSH‐RH in Teleosts

BioEssays, EarlyView.
Regarding pituitary gonadotropin regulation, recent studies have shown that in mammals, FSH and LH are regulated by a single GnRH (solo GnRH model), whereas in teleosts, they are regulated by CCK (FSH‐RH) and GnRH (LH‐RH), respectively (dual GnRH model).
Daichi Kayo, Shun Kenny Uehara, Muhammad Rahmad Royan, Shinji Kanda   +3 more
wiley   +1 more source

Postmenopausal Hyperandrogenism in a Patient With an Adrenal Adenoma: How Should We Approach It?

AACE Clinical Case Reports, 2016
: Objective: To report the case of a postmenopausal woman with adrenal adenoma and severe hyperandrogenism due to bilateral ovarian hyperthecosis.Methods: We describe the clinical findings and diagnostic tests used to determine the source of excess ...
Lilian C. Mendoza-Mathison, MD, M. Fernanda Rabasa, MD, Cintia González, MD, PhD, Antonio Pérez, MD, PhD   +3 more
doaj   +1 more source

Addition of a carboxy-terminal tail to the normally tailless gonadotropin-releasing hormone receptor impairs fertility in female mice

eLife, 2021
Gonadotropin-releasing hormone (GnRH) is the primary neuropeptide controlling reproduction in vertebrates. GnRH stimulates follicle-stimulating hormone (FSH) and luteinizing hormone (LH) synthesis via a G-protein-coupled receptor, GnRHR, in the pituitary
Chirine Toufaily, Jérôme Fortin, Carlos AI Alonso, Evelyne Lapointe, Xiang Zhou, Yorgui Santiago-Andres, Yeu-Farn Lin, Yiming Cui, Ying Wang, Dominic Devost, Ferdinand Roelfsema, Frederik Steyn, Aylin C Hanyaloglu, Terence E Hébert, Tatiana Fiordelisio, Derek Boerboom, Daniel J Bernard   +16 more
doaj   +1 more source

Microtranscriptome regulation by gonadotropin-releasing hormone [PDF]

Molecular and Cellular Endocrinology, 2009
Gonadotropin-releasing hormone (GnRH) regulates biosynthesis in the pituitary gonadotrope via a complex signaling and gene network. Small non-coding microRNAs (miRNA) can play important roles in gene expression. We investigated the microtranscriptome in the mouse L?T2 gonadotrope cell line using microarray, single molecule coincidence detection assays,
Tony Yuen, Tearina Chu, Stuart C. Sealfon, Frederique Ruf   +3 more
openaire   +3 more sources

Interspecific comparisons of anuran embryonic epidermal landscapes and energetic trade‐offs in response to changes in salinity

Developmental Dynamics, EarlyView.
Abstract Background Freshwater salinization is an emerging stressor in amphibian populations, and embryonic stages are most vulnerable. To better understand the variation in embryonic osmoregulation, we challenged embryos of two phylogenetically diverse anuran species, Xenopus laevis and Lithobates (Rana) sylvaticus, along a gradient of non‐lethal ...
Kourtnie Whitfield, Erica J. Crespi
wiley   +1 more source

Heart failure with preserved ejection fraction in cancer patients and survivors. A scientific statement of the Heart Failure Association of the ESC and the ESC Council of Cardio‐Oncology

European Journal of Heart Failure, EarlyView.
Specific characteristics of HFpEF universal definition in cancer patients. Abstract Heart failure with preserved ejection fraction (HFpEF) is increasingly recognized in cancer patients and survivors, yet it remains underdiagnosed and its epidemiology largely unknown.
Kalliopi Keramida, Teresa Lopez‐Fernandez, Markus S. Anker, Mark C. Petrie, Pietro Ameri, Lisa J. Anderson, Jutta Bergler‐Klein, Anita Deswal, Dimitrios Farmakis, Borja Ibañez, Carolyn S.P. Lam, Ninian N. Lang, Alexander R. Lyon, Mariana Mirabel, Brenda Moura, Walter J. Paulus, Amina Rakisheva, Gianluigi Savarese, Michele Senni, Carlo Gabriele Tocchetti, Marco Metra, Gerasimos Filippatos   +21 more
wiley   +1 more source

Uterine “twisting sign”: A new potential ultrasonographic soft marker for deep endometriosis

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract Objective The objective of the current study was to evaluate the “twisting sign,” defined as uterine fundus rotation observed on transvaginal sonography (TVS), as a potential soft marker for deep endometriosis (DE) and its association with specific DE localizations and indirect signs.
Fabio Barra, Simone Ferrero, Umberto Perrone, Giulio Evangelisti, Alessandra Pulliero, Alberto Izzotti, Umberto Leone Roberti Maggiore, Stefano Bogliolo   +7 more
wiley   +1 more source

Final oocyte maturation with a dual trigger compared to human chorionic gonadotropin trigger in antagonist co-treated cycles: A randomized clinical trial

Middle East Fertility Society Journal, 2018
Objective: This clinical trial compared the effect of a dual trigger treatment (combination of gonadotropin-releasing hormone (GnRH) agonist and human chorionic gonadotropin (hCG) and hCG alone on oocyte quality and metaphase II oocytes’ number. Methods:
Ashraf Alleyassin, Marzieh Ghasemi, Marzieh Aghahosseini, Leila Safdarian, Fatemeh Sarvi, Amir Almasi-Hashiani, Sedigheh Hosseinimousa, Aida Najafian, Arezoo Esmailzadeh   +8 more
doaj   +1 more source

Urinary tract endometriosis: Revisiting the definition of ureterolysis

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract Objectives To report the incidence of urinary tract endometriosis (UTE) among patients with deep endometriosis, and to analyze surgical procedures, the rate of complications, and the recurrence rate in patients with UTE managed in a French expert center.
Constance Durant Des Aulnois, Léo Razakamanantsoa, Adrien Crestani, Ylan Abrahami, Steeve Doizi, Florie Gomez, Cyril Touboul, Isabelle Thomassin Naggara, Emile Daraï, Yohann Dabi   +9 more
wiley   +1 more source