Progress in Clinical Research on Gonadotropin-Releasing Hormone Receptor Antagonists for the Treatment of Prostate Cancer [PDF]
Drug Design, Development and Therapy, 2021 Yi-Fu Liu, Sheng-Qiang Fu, Yu-Chang Yan, Bin-Bin Gong, Wen-Jie Xie, Xiao-Rong Yang, Ting Sun, Ming Ma Department of Urology, The First Affiliated Hospital of Nanchang University, Nanchang, 330000, Jiangxi Province, People’s Republic of ...
Liu YF +7 more
doaj +4 more sources
AXL receptor tyrosine kinase modulates gonadotropin-releasing hormone receptor signaling [PDF]
Cell Communication and Signaling, 2023 Background Gonadotropin-releasing hormone (GnRH) receptors are essential for reproduction and are expressed in numerous urogenital, reproductive, and non-reproductive cancers.
Pardis Mohammadzadeh +2 more
doaj +2 more sources
Editorial: Gonadotropin-Releasing Hormone Receptor Signaling and Functions [PDF]
Frontiers in Endocrinology, 2018 Ivana Bjelobaba +2 more
doaj +5 more sources
Specific Targeting of Recombinant Human Pancreatic Ribonuclease 1 using Gonadotropin-Releasing Hormone Targeting Peptide toward Gonadotropin-Releasing Hormone Receptor-Positive Cancer Cells [PDF]
Iranian Journal of Medical Sciences, 2021 Background: Targeted drug delivery is a novel method to specifically deliver anticancer therapeutics to tumor sites. Gonadotropin-releasing hormone (GnRH) is a decapeptide, and its target binding property has attracted attention as a means of targeted ...
Amir Maleksabet +4 more
doaj +2 more sources
Gonadotropin-Releasing Hormone Receptor (GnRHR) and Hypogonadotropic Hypogonadism. [PDF]
Int J Mol Sci, 2023 Human sexual and reproductive development is regulated by the hypothalamic-pituitary-gonadal (HPG) axis, which is primarily controlled by the gonadotropin-releasing hormone (GnRH) acting on its receptor (GnRHR). Dysregulation of the axis leads to conditions such as congenital hypogonadotropic hypogonadism (CHH) and delayed puberty.
Fanis P +4 more
europepmc +3 more sources
Gonadotropin-releasing hormone receptor inhibits triple-negative breast cancer proliferation and metastasis [PDF]
Journal of International Medical Research, 2022 Background Gonadotropin-releasing hormone receptor (GnRHR) is expressed in several malignant tumors and inhibits the proliferation and metastasis of cancer cells, but its role in triple-negative breast cancers (TNBCs) is unclear.
Cai-Ping Chen, Xiang Lu
doaj +2 more sources
Natural autoantibodies to the gonadotropin-releasing hormone receptor in polycystic ovarian syndrome. [PDF]
PLoS ONE, 2021 ContextPolycystic ovarian syndrome (PCOS) is a complex disease with different subtypes and unclear etiology. Among the frequent comorbidities are autoimmune diseases, suggesting that autoantibodies (aAb) may be involved in PCOS pathogenesis.ObjectiveAs ...
Lisa-Marie Sattler +9 more
doaj +2 more sources
First in vivo evaluation of a potential SPECT brain radiotracer for the gonadotropin releasing hormone receptor [PDF]
BMC Research Notes, 2018 Objectives In vivo evaluations of a gonadotropin releasing hormone-receptor single photon emission computed tomography radiotracer for non-invasive detection of gonadotropin releasing homone-receptors in brain.
Richard Fjellaksel +7 more
doaj +2 more sources
Intrinsic and Regulated Gonadotropin-Releasing Hormone Receptor Gene Transcription in Mammalian Pituitary Gonadotrophs [PDF]
Frontiers in Endocrinology, 2017 The hypothalamic decapeptide gonadotropin-releasing hormone (GnRH), acting via its receptors (GnRHRs) expressed in pituitary gonadotrophs, represents a critical molecule in control of reproductive functions in all vertebrate species.
Marija M. Janjic +2 more
doaj +2 more sources
Structure of the human gonadotropin-releasing hormone receptor GnRH1R reveals an unusual ligand binding mode [PDF]
Nature Communications, 2020 The human gonadotropin-releasing hormone receptor GnRH1R is a GPCR with an important role in the human reproductive system and of interest as a drug target.
Wei Yan +11 more
doaj +2 more sources