Results 111 to 120 of about 1,076 (281)

DCAF13 Safeguards Hematopoietic Stem Cells via RRS1‐Regulated Ribosome Biogenesis

Advanced Science, EarlyView.
This study establishes DCAF13 as an essential regulator for hematopoietic stem cell (HSC) function. Its deletion in mice causes lethal pancytopenia and HSC depletion. Mechanistically, DCAF13 interacts with RRS1 and mediates its non‐degradative K27‐linked ubiquitination, thereby stabilizing RRS1 to maintain ribosome biogenesis and protein translation ...
Mengke Li, Yuxin Wu, Shuai Zhou, Peipei Tang, Jiaming Wei, Ling Liu, Zhenyi Wang, Deyang Shi, Shengnan Yuan, Qingyu Zhang, Shihui Wang, Qing Zhang, Huan Zhao, Rui Zhang, Yingying Wang, Shiwei Yang, Xiangli Chen, Xiaojing Shi, Guangzhi Liu, Yuwei Zhang, Jinming Li, Xu Dong Zhang, Rick F Thorne, Dongping Wei, Zumin Zhu, Song Chen   +25 more
wiley   +1 more source

A Nanoparticle‐Integrated Complete Manufacturing Pipeline of Chemically Engineered Exosomes

Advanced Science, EarlyView.
We report a novel manufacture technology of chemically engineered exosomes. The four steps of manufacturing, i.e., biogenesis, loading, isolation, and storage, are integrated by the use of a nanoparticle. The manufacture technology incorporates three innovative components, i.e., a new nano‐bio effect, a new composite nanoparticle, and a new isolation ...
Xiaowei Wen, Zixing Xu, Zerun Hao, Yanming Chen, Kai Xie, Haofan Yin, Xueying Wang, Jie Min, Sihan Sun, Baiding Chen, Chengxiu Ling, Mingming Xu, Yizhao Chen, Gang Ruan   +13 more
wiley   +1 more source

GPCRs in CAR‐T Cell Immunotherapy: Expanding the Target Landscape and Enhancing Therapeutic Efficacy

Advanced Science, EarlyView.
Chimeric antigen receptor T cell therapy faces dual challenges of target scarcity and an immunosuppressive microenvironment in solid tumors. This review highlights how G protein‐coupled receptors can serve as both novel targets to expand the therapeutic scope and functional modules to enhance CAR‐T cell efficacy.
Zhuoqun Liu, Yuchen Xiao, Yamin Zhao, Lihe Dai, David J.H. Shih, Shikang Liang, Honglei Tian, Liu Liu, Feng Tian, Bing Liu, Lei Chang, Chao Zhang   +11 more
wiley   +1 more source

A rare case of Good’s syndrome presented with recurrent COVID pneumonia

The Journal of Association of Chest Physicians
A 45-year-old male patient with a history of thymectomy presented to the emergency with a history of cough, breathlessness, and fever for the past 3 days. He had undergone a thymectomy in the year 2017 for a thymoma.
Udvass Kumar Kotokey
doaj   +1 more source

Combination Immunotherapy as a Promising Strategy to Overcome Immunotherapy Resistance: From Emergence to Next‐Generation Approaches

Advanced Science, EarlyView.
This review examines emerging combination immunotherapy strategies tailored to distinct tumor microenvironments and highlights next‐generation biomarkers that guide response prediction and treatment personalization. It integrates lessons from unsuccessful trials, addresses toxicity challenges, and outlines approaches for early biomarker discovery and ...
Asmita Pandey, Sudhir Kumar Rai, Li Ma, Lauren Higa, Vedbar Khadka, Hua Yang, Youping Deng   +6 more
wiley   +1 more source

Significant decreased CXCR3+ phenotype Tfh1 cells in three Good’s syndrome patients

Frontiers in Immunology
BackgroundGood’s syndrome (GS) is a rare acquired immunodeficiency defined by the co-occurrence of thymoma and hypogammaglobulinemia. Follicular helper T (Tfh) cells, a specialized CD4+ T cell subset, play a critical role in supporting B-cell antibody ...
Yanxia Chen, Junwu Zhang, Jinyao Ni, Jing He, Jinlin Liu, Jinlin Liu   +5 more
doaj   +1 more source

Delayed Diagnosis of Good Syndrome

The Journal of Allergy and Clinical Immunology: In Practice, 2020
Jessica D, Gereige, Paul J, Maglione, Miren, Guenechea-Sola   +2 more
openaire   +3 more sources

Montana Kaimin, April 8, 1986 [PDF]

, 1986
Student newspaper of the University of Montana, Missoula.https://scholarworks.umt.edu/studentnewspaper/8872/thumbnail ...
Associated Students of the University of Montana
core   +1 more source

Autoimmune Encephalitis in Acute Care—Pathology, Diagnosis, and Management

Advanced Science, EarlyView.
ABSTRACT Autoimmune encephalitis (AE) is characterized by immune‐mediated inflammation of the brain parenchyma, presenting with various neurological syndromes, including but not limited to seizures, altered consciousness, neuropsychiatric symptoms, and movement disorders.
Suneesh Thilak, David Okoh, William Scotton, Shanika Samarasekera, Vikram Patil, Suresh Renukappa, Andrew Macduff, Subashini Suresh, Rajeev Krishnadas, Tonny Veenith   +9 more
wiley   +1 more source

Immunological Tolerance: One of Biology's Most Intriguing Mysteries [PDF]

, 1999
Bach FH, Barnard CN, Billingham RE, Calne RY, Calne RY, Carrel A, Dausset J, Demirleau, Derom F, Gatti RA, Gibson T, Goodwin WE, Groth CG, Hamburger J, Kuss R, Lillehei RC, Mazariegos GV, Meeker W, Merrill JP, Moore FD, Moore FD, Murray JE, Owen RD, Przepiorka D, Ramos HC, Schwartz R, Schwartz R, Starzl TE, Starzl TE, Starzl TE, Starzl TE, Starzl TE, Starzl TE, Starzl TE, Starzl TE, Starzl TE, Starzl TE, Starzl TE, Starzl TE, Starzl TE, Starzl TE, Starzl TE, Starzl TE, Starzl TE, Thomas ED, Wessman M, Zinkernagel RM, Zinkernagel RM, Zukoski CF   +48 more
core   +1 more source