Results 91 to 100 of about 14,696,344 (291)

Good Practice in Action Fact Sheet 120

, 2021
This practitioner factsheet looks at the factors that counsellors and psychotherapists need to keep in mind when working with clients who present at risk.
Reeves, Andrew
core   +1 more source

Clinical trials with Good Clinical Practice

Acta Médica del Centro, 2014
A standard for the conduct of clinical trials and to ensure quality constitute Good Clinical Practice, which are aimed at ensuring publicly protection of subjects participating in the trials and ensure the credibility of the data obtained and based on ...
Nerelys Díaz Lima, Aimeé Hurtado Pérez, María Margarita Ríos Cabrera   +2 more
doaj  

Good Practice Guidelines in Phonetic Transcription: Survey in Clinical Practice.

, 2014
Background: The Royal College of Speech and Language Therapists (2012) have recently published 'Good Practice Guidelines for Transcription of Children's Speech Sample in Clinical Practice and Research'.
Skwarcewicz, Michalina
core  

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

CLINICAL AND PRECLINICAL RESEARCH IN WARTIME CONDITIONS: INSIGHTS FROM A SCIENTIFIC FORUM

Proceedings of the Shevchenko Scientific Society: Medical Sciences
The article presents an overview of current challenges and development prospects in clinical and preclinical research, as discussed at the Forum “Clinical and Preclinical Research in Wartime Conditions: Organization and Development Prospects,” held in ...
Nataliya Matolinets, Mykhailo Babenko, Johan Van Eldere   +2 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Comprehensive overview of antibody drug-related clinical studies in gynecology: insights from ClinicalTrials.gov

Frontiers in Medicine
Antibodies have been widely used globally over the past decade and play an increasingly important role in modern medicine. Notably, significant advancements have been achieved in the realm of gynecology, particularly in gynecological cancers.
Xiaoling Zhou, Li Xiao, Fan Lai, Wei Chen, Congrong Zhou, Yi Deng, Tao Wang, Shasha Xing, Haoyang Diao, Mi Tang, Wenmei Guo, Erdan Luo   +11 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Superficial supervision: Are we placing clinicians and clients at risk?

, 2010
Mental heath nurses recognise the importance of professional boundaries and therapeutic relationships and understand that clinical supervision is an important component to good clinical practice and their ongoing professional development.
Fedoruk, Maria, McCutcheon, Helen Hunter Irving, Gardner, Andrew, Mccutcheon, Helen, Gardner, A., McCutcheon, H., Andrew Gardner, Maria Fedoruk, Fedoruk, M., Helen McCutcheon   +9 more
core   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source