Results 91 to 100 of about 1,091,889 (296)

EUPATI and Patients in Medicines Research and Development: Guidance for Patient Involvement in Regulatory Processes

Frontiers in Medicine, 2018
The importance and merits of greater patient involvement in medicines research and development (R&D) are commonly acknowledged and is thought to offer benefits for all involved parties.
David Haerry, Cordula Landgraf, Kay Warner, Amy Hunter, Ingrid Klingmann, Matthew May, Wolf See   +6 more
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Safety Profile of Intravenous Ferulic Acid Nanoparticles: Acute Toxicity and Neurological Effects in Sprague-Dawley Rats

Nanotechnology, Science and Applications
Hao Huang,1,2,* Yan Xuan,3,* Zeng-Chun Ma4 1GCP Institutional Office, The First People’s Hospital of Neijiang, Neijiang, Sichuan, 641000, People’s Republic of China; 2Department of Clinical Pharmacy, Chengdu Qingbaijiang District People’s
Huang H, Xuan Y, Ma ZC
doaj  

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Autonomy versus futility? Barriers to good clinical practice in end-of-life care: A Queensland case

, 2012
Findings from a Queensland coronial inquest highlight the complex clinical, ethical and legal issues that arise in end-of-life care when clinicians and family members disagree about a diagnosis of clinical futility.• The tension between the law and best ...
Miligan, Eleanor, Milligan, Eleanor, White, Benjamin P., White, Ben, Parker, Malcolm, Lawrence, Sean, Winch, Sarah, Willmott, Lindy   +7 more
core   +1 more source

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Clinical trials with Good Clinical Practice

Acta Médica del Centro, 2014
A standard for the conduct of clinical trials and to ensure quality constitute Good Clinical Practice, which are aimed at ensuring publicly protection of subjects participating in the trials and ensure the credibility of the data obtained and based on ...
Nerelys Díaz Lima, Aimeé Hurtado Pérez, María Margarita Ríos Cabrera   +2 more
doaj  

PARK(ing) time–How park deficiency affects the biological clock in a Drosophila model of Parkinson's disease

FEBS Letters, EarlyView.
Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara, Kinga Skoczek, Elzbieta Pyza, Milena Damulewicz   +3 more
wiley   +1 more source

Good clinical practice in dubious head trauma – the problem of retained intracranial foreign bodies

, 2012
Bernhard R Fischer,1 Yousef Yasin,2 Markus Holling,2 Volker Hesselmann31Department of Neurotraumatology, BG-University Hospital Bergmannsheil, Ruhr-University Bochum, Bochum, Germany; 2Department of Neurosurgery, 3Institute for Clinical Radiology ...
Holling M, Hesselmann V, Fischer BR, Yasin Y   +3 more
core  

Good clinical practice for clinical trials

How to show MHRA you're meeting good clinical practice standards and what to expect from an inspection. Read the updated guidance from Medicines and Healthcare products Regulatory Agency published on 22 July ...
lsgilbert
core   +1 more source