Results 101 to 110 of about 1,091,889 (296)

Comprehensive overview of antibody drug-related clinical studies in gynecology: insights from ClinicalTrials.gov

Frontiers in Medicine
Antibodies have been widely used globally over the past decade and play an increasingly important role in modern medicine. Notably, significant advancements have been achieved in the realm of gynecology, particularly in gynecological cancers.
Xiaoling Zhou, Li Xiao, Fan Lai, Wei Chen, Congrong Zhou, Yi Deng, Tao Wang, Shasha Xing, Haoyang Diao, Mi Tang, Wenmei Guo, Erdan Luo   +11 more
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Good practice in mental health care for socially marginalised groups in Europe: a qualitative study of expert views in 14 countries [PDF]

, 2012
Background Socially marginalised groups tend to have higher rates of mental disorders than the general population and can be difficult to engage in health care. Providing mental health care for these groups represents a particular challenge, and evidence
Greacen, Tim, Macassa, Gloria,, Straßmayr, Christa, Jacek Moskalewicz, Kluge Ulrike, Macassa Gloria, Barry Margaret M, Gloria Macassa, Priebe, Stefan, Schene, AH, Gaddini, Andrea, Petra Holcnerová, Macassa, Gloria, Gaddini Andrea, Barry, Margaret M, Aleksandra Matanov, Margaret M Barry, Barry, Margaret M., Moskalewicz, J,, Barry, Margaret M,, Barros, H, Greacen, T, Schor, Ruth, Greacen Tim, Ruth Schor, Díaz-Olalla José, Matanov, Alexandra,, Moskalewicz, Jasec,, Barros, Henrique, Barry, Margareth M,, Kluge, U, Holcnerová, Petra,, Barros, Henrique,, Moskalewicz, Jacek, Lorant Vincent, Matanov, Alexandra, Aart H Schene, Schor Ruth, Priebe, S, Manuel Diaz-Olalla, J, Matanov, Aleksandra, Holcnerová, Petra, Schene, Aart H., Schene, Aart H,, Henrique Barros, Gaddini, Andrea,, Ulrike Kluge, Díaz-Olalla, José Manuel, Priebe, Stefan,, Strassmayr, C, Lorant, V, Lorant, V,, Barros Henrique, Barry, MM, Vincent Lorant, Tim Greacen, Macassa, G, Greacen, Tim,, Priebe Stefan, Gaddini, A,, Díaz-Olalla, José Manuel,, Gabor Edina, Stefan Priebe, Matanov Aleksandra, Gabor, E, Lorant, Vincent,, José Manuel Díaz-Olalla, Holcnerova, P, Holcnerová Petra, Matanov, A, Straßmayr, Christa,, Schene Aart H, Schor, R, Moskalewicz Jacek, Kluge, Ulrike,, Christa Straßmayr, Andrea Gaddini, Kluge, U,, Schene, Aart H, Gabor, Edina, Kluge, Ulrike, Lorant, Vincent, Edina Gabor, Moskalewicz, J, Straßmayr Christa, Gabor, Edina,, Gaddini, A, Schor, Ruth,, Schene, AH,   +88 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Investigating the core skills of clinical supervision : a qualitative analysis [PDF]

, 1998
This study used self-reports of the experience of Clinical Psychology trainees on the Doctor of Clinical Psychology course at the University of Leeds as the basis for developing a model of effective clinical supervision from the users' perspective ...
Green, David Russell
core  

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Good Practice Guidelines in Phonetic Transcription: Survey in Clinical Practice.

, 2014
Background: The Royal College of Speech and Language Therapists (2012) have recently published 'Good Practice Guidelines for Transcription of Children's Speech Sample in Clinical Practice and Research'.
Skwarcewicz, Michalina
core  

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Management of autism in children and young people : a good clinical practice guideline - Appendix

, 2014
181 p.ill.,1. PARTICIPANTS IN THE DEVELOPMENT OF THE GUIDELINE 5 -- 1.1. COMPOSITION OF THE GUIDELINE DEVELOPMENT GROUP (GDG) 5 -- 1.2. COMPOSITION OF THE STAKEHOLDER PANEL 7 -- 1.3. EXTERNAL EXPERTS 9 -- 1.4.
Veereman, Geneviève
core   +1 more source