Results 11 to 20 of about 1,062,874 (251)

Bacteria Isolated From Milk of Dairy Cows With and Without Clinical Mastitis in Different Regions of Australia and Their AMR Profiles

Frontiers in Veterinary Science, 2021
Mastitis is the most common disease in dairy cattle worldwide. The objectives of this study were to estimate the prevalence of different bacterial species associated with mastitis from dairy herds located in geographically and climatically distinct zones
Hulayyil Al-harbi, Hulayyil Al-harbi, Shahab Ranjbar, Robert J. Moore, John I. Alawneh, John I. Alawneh   +5 more
doaj   +1 more source

Good clinical practice: International quality standard for clinical trials [PDF]

Stomatološki glasnik Srbije, 2003
A clinical trial is one of the most important examples of experimental studies. Clinical trials represent an indispensable tool for testing, in a rigorous scientific manner, the efficacy of new therapies.
Radulović Siniša S.
doaj   +1 more source

On the use of probiotics to improve dairy cattle health and productivity [PDF]

Microbiology Australia, 2020
Probiotics are genetically identifiable, live microorganisms that when administered in adequate amounts, confer appropriately sized health benefit (e.g. correcting dysbiosis, immunomodulatory effect) on a target host.
John Alawneh, Timothy Olchowy, Justine Gibson, Hulayyil Al-harbi, Divya Krishnan   +4 more
doaj  

Cross-Border Access to Clinical Trials in the EU: Exploratory Study on Needs and Reality

Frontiers in Medicine, 2020
Objectives: To analyze the current situation of cross-border access to clinical trials in the EU with an overview of stakeholders' real-life experience, and to identify the needs, challenges, and potential for facilitation of cross-border access.Methods:
Teodora Lalova, Teodora Lalova, Cristina Padeanu, Anastassia Negrouk, Denis Lacombe, Jan Geissler, Ingrid Klingmann, Isabelle Huys   +7 more
doaj   +1 more source

Survey and Sequence Characterization of Bovine Mastitis-Associated Escherichia coli in Dairy Herds

Frontiers in Veterinary Science, 2020
Escherichia coli is frequently associated with mastitis in cattle. “Pathogenic” and “commensal” isolates appear to be genetically similar. With a few exceptions, no notable genotypic differences have been found between commensal and mastitis-associated E.
John I. Alawneh, John I. Alawneh, Ben Vezina, Hena R. Ramay, Hulayyil Al-Harbi, Hulayyil Al-Harbi, Ameh S. James, Martin Soust, Robert J. Moore, Timothy W. J. Olchowy, Timothy W. J. Olchowy   +10 more
doaj   +1 more source

Solving the Evidence Interpretability Crisis in Health Technology Assessment: A Role for Mechanistic Models?

Frontiers in Medical Technology, 2022
Health technology assessment (HTA) aims to be a systematic, transparent, unbiased synthesis of clinical efficacy, safety, and value of medical products (MPs) to help policymakers, payers, clinicians, and industry to make informed decisions.
Eulalie Courcelles, Jean-Pierre Boissel, Jacques Massol, Ingrid Klingmann, Riad Kahoul, Marc Hommel, Emmanuel Pham, Alexander Kulesza   +7 more
doaj   +1 more source

The mechanism of RNA methylation writing protein-related prognostic genes in lung adenocarcinoma based on bioinformatics

Frontiers in Genetics
ObjectiveRNA methylation modifications play biological roles in tumorigenicity and immune response, mainly mediated by the “writer” enzyme. Lung adenocarcinoma (LUAD) development is closely related to RNA methylation.
Sha Yin, Guangyan Luo, Lei Luo
doaj   +1 more source

Exosomes in clinical trial and their production in compliance with good manufacturing practice

Tzu Chi Medical Journal, 2020
Exosomes, 60-200-nm extracellular vesicles secreted from cells, have been used as an active pharmaceutical ingredient or drug carrier in disease treatment. Human- and plant-derived exosomes are registered in clinical trials, but more complete reports are
Yu-Shuan Chen, En-Yi Lin, Tzyy-Wen Chiou, Horng-Jyh Harn   +3 more
doaj   +1 more source

Stakeholders’ views on the most and least helpful aspects of the ICH E6 GCP guideline and their aspirations for the revision of ICH E6(R2)

Contemporary Clinical Trials Communications, 2022
Background: The International Council for Harmonisation of Technical Requirements for Pharmaceuticals for Human Use (ICH) has published the ICH E6(R2) Good Clinical Practice (GCP) guideline, which provides standards for the design, conduct, documentation,
Carrie Dombeck, Teresa Swezey, Annemarie Forrest, Pamela Tenaerts, Amy Corneli   +4 more
doaj   +1 more source

Why are clinical trials necessary in India?

Perspectives in Clinical Research, 2014
Clinical trials are emerging as an important activity in India as it is an essential component of the drug discovery and development program to which India is committed.
Subramani Poongothai, Ranjit Unnikrishnan, Jeyakumar Balasubramanian, Mohan Damodaran Nair, Viswanathan Mohan   +4 more
doaj   +1 more source