Results 31 to 40 of about 1,091,889 (296)

Clinical research on RSV prevention in children and pregnant women: progress and perspectives

Frontiers in Immunology
Respiratory syncytial virus (RSV) is a significant causative agent of bronchitis and pneumonia in infants and children. The identification and structural analysis of the surface fusion glycoprotein of RSV represents a pivotal advancement in the ...
Xuejia Gong, Erdan Luo, Li Fan, Wanggang Zhang, Yan Yang, Yuhua Du, Xiao Yang, Shasha Xing   +7 more
doaj   +1 more source

Serological Benefit of SARS‐CoV‐2 Vaccination Relative to Infection in Children With Acute Lymphoblastic Leukemia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Children with acute lymphoblastic leukemia (ALL) are at risk of severe outcomes from SARS‐CoV‐2 (SCV2). In the post‐pandemic context, where most children have been infected with SCV2, there are limited data on whether vaccination remains beneficial in children with ALL.
Janna R. Shapiro, Freda Qi, Karen Colwill, Alina D. Dorogy, Ying Liu, Michelle Science, Anne‐Claude Gingras, James M. Rini, Sumit Gupta, Sarah Alexander, Shelly Bolotin, Tania H. Watts   +11 more
wiley   +1 more source

Cost‐effectiveness of the utilization of “good practice” or the lack thereof according to a bronchiolitis evidence‐based clinical practice guideline

, 2019
Rationale, aims, and objectives: The aim of the present study was to determine the cost-effectiveness of the utilization of “good practice” according to a bronchiolitis clinical practice guideline (CPG) in a population of infants hospitalized for acute ...
Sossa-Briceño, Mónica P., Carlos E. Rodriguez‐Martinez, Monica P. Sossa‐Briceño, Rodríguez Martínez, Carlos E., Castro-Rodriguez, Jose A., Jose A. Castro‐Rodriguez, Rodríguez-Martínez, Carlos E., Castro Rodríguez, José Antonio, Sossa Briceño, Mónica P.   +8 more
core   +1 more source

Induction of cytochrome P450 via upregulation of CAR and PXR: a potential mechanism for altered florfenicol metabolism by macranthoidin B in vivo

Frontiers in Pharmacology
IntroductionMacranthoidin B (MB) is a primary active component of Flos Lonicerae. In Chinese veterinary clinics, Flos Lonicerae is frequently used in combination with florfenicol to prevent and treat infections in livestock and poultry.
Si-cong Li, Si-cong Li, Bin Wang, Bin Wang, Min Zhang, Min Zhang, Qin Yin, Zi-yi Yang, Zi-yi Yang, Xu-ting Li, Xu-ting Li, Ge Liang, Ge Liang   +12 more
doaj   +1 more source

EUPATI Guidance for Patient Involvement in Medicines Research and Development (R&D); Guidance for Pharmaceutical Industry-Led Medicines R&D

Frontiers in Medicine, 2018
The importance and merits of greater patient involvement in medicines research and development (R&D) are commonly acknowledged and are thought to offer benefits for all involved parties.
Kay Warner, Wolf See, David Haerry, Ingrid Klingmann, Amy Hunter, Matthew May   +5 more
doaj   +1 more source

More than a box to check: Research sponsor and clinical investigator perspectives on making GCP training relevant

Contemporary Clinical Trials Communications, 2020
Background: Good clinical practice (GCP) training is the industry expectation for ensuring quality conduct of registrational clinical trials. However, concerns exist about whether the current structure and delivery of GCP training sufficiently prepares ...
Teresa Swezey, F. Hunter McGuire, Patricia Hurley, Janette Panhuis, Kathy Goldstein, Tina Chuck, Carrie Dombeck, Brian Perry, Christina Brennan, Natasha Phrsai, Amy Corneli   +10 more
doaj   +1 more source

Claudin‐6 Protein Expression in Atypical Teratoid/Rhabdoid Tumors Is Strongly Enriched in the Molecular Subgroup AT/RT‐TYR

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Claudin‐6 has emerged as a promising immunotherapeutic target, yet protein‐level data in atypical teratoid/rhabdoid tumors (AT/RTs) have been inconsistent. We analyzed 36 well‐characterized AT/RT samples and found membranous claudin‐6 protein expression in 58% of cases, with striking enrichment in the molecular subgroup AT/RT‐TYR (100%) and ...
Victoria E. Fincke, Christian Thomas, Michael C. Frühwald, Pascal D. Johann, Martin Hasselblatt   +4 more
wiley   +1 more source

Good Clinical Practices

International Journal of Advanced Research in Science, Communication and Technology, 2023
Good Clinical Practice (GCP) is an international ethical and scientific quality standard for the design, conduct, performance, monitoring, auditing, recording, analyses and reporting of clinical trials. It also serves to protect the rights, integrity and confidentiality of trial subjects.
openaire   +1 more source

Time Toxicity in Wilms Tumor: Quantifying the Burden of Healthcare Interaction in the First Year After Diagnosis

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Wilms tumor (WT) treatment imposes a significant time burden on patients and their families. Time toxicity is a patient‐centered metric that quantifies the burden of healthcare interaction. We sought to define time toxicity in the first year after diagnosis of WT and hypothesized that it would increase as tumor stage and treatment ...
Caleb Q. Ashbrook, Veerain Gupta, Nicholas J. Clark, Vijay Rings, Lauren E. Corona, Douglass B. Clayton, Daniel J. Benedetti   +6 more
wiley   +1 more source

Guide to good clinical practice.

, 2022
The complete text of the Guide to good clinical practice, as published by the Thompson Publishing Group Inc., authored by Gary Yingling and Mary Bernadette ...
Yingling, Gary,, Ott, Mary Bernadette,
core