Results 21 to 30 of about 1,091,889 (296)

Solving the Evidence Interpretability Crisis in Health Technology Assessment: A Role for Mechanistic Models?

Frontiers in Medical Technology, 2022
Health technology assessment (HTA) aims to be a systematic, transparent, unbiased synthesis of clinical efficacy, safety, and value of medical products (MPs) to help policymakers, payers, clinicians, and industry to make informed decisions.
Eulalie Courcelles, Jean-Pierre Boissel, Jacques Massol, Ingrid Klingmann, Riad Kahoul, Marc Hommel, Emmanuel Pham, Alexander Kulesza   +7 more
doaj   +1 more source

Survey and Sequence Characterization of Bovine Mastitis-Associated Escherichia coli in Dairy Herds

Frontiers in Veterinary Science, 2020
Escherichia coli is frequently associated with mastitis in cattle. “Pathogenic” and “commensal” isolates appear to be genetically similar. With a few exceptions, no notable genotypic differences have been found between commensal and mastitis-associated E.
John I. Alawneh, John I. Alawneh, Ben Vezina, Hena R. Ramay, Hulayyil Al-Harbi, Hulayyil Al-Harbi, Ameh S. James, Martin Soust, Robert J. Moore, Timothy W. J. Olchowy, Timothy W. J. Olchowy   +10 more
doaj   +1 more source

The mechanism of RNA methylation writing protein-related prognostic genes in lung adenocarcinoma based on bioinformatics

Frontiers in Genetics
ObjectiveRNA methylation modifications play biological roles in tumorigenicity and immune response, mainly mediated by the “writer” enzyme. Lung adenocarcinoma (LUAD) development is closely related to RNA methylation.
Sha Yin, Guangyan Luo, Lei Luo
doaj   +1 more source

Exosomes in clinical trial and their production in compliance with good manufacturing practice

Tzu Chi Medical Journal, 2020
Exosomes, 60-200-nm extracellular vesicles secreted from cells, have been used as an active pharmaceutical ingredient or drug carrier in disease treatment. Human- and plant-derived exosomes are registered in clinical trials, but more complete reports are
Yu-Shuan Chen, En-Yi Lin, Tzyy-Wen Chiou, Horng-Jyh Harn   +3 more
doaj   +1 more source

Stakeholders’ views on the most and least helpful aspects of the ICH E6 GCP guideline and their aspirations for the revision of ICH E6(R2)

Contemporary Clinical Trials Communications, 2022
Background: The International Council for Harmonisation of Technical Requirements for Pharmaceuticals for Human Use (ICH) has published the ICH E6(R2) Good Clinical Practice (GCP) guideline, which provides standards for the design, conduct, documentation,
Carrie Dombeck, Teresa Swezey, Annemarie Forrest, Pamela Tenaerts, Amy Corneli   +4 more
doaj   +1 more source

Why are clinical trials necessary in India?

Perspectives in Clinical Research, 2014
Clinical trials are emerging as an important activity in India as it is an essential component of the drug discovery and development program to which India is committed.
Subramani Poongothai, Ranjit Unnikrishnan, Jeyakumar Balasubramanian, Mohan Damodaran Nair, Viswanathan Mohan   +4 more
doaj   +1 more source

European Standard Clinical Practice Guideline and EXPeRT Recommendations for the Diagnosis and Management of Gastroenteropancreatic Neuroendocrine Neoplasms in Children and Adolescents

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Pediatric gastroenteropancreatic neuroendocrine neoplasms (GEP‐NENs) are extremely rare and clinically heterogeneous. Management has largely been extrapolated from adult practice. This European Standard Clinical Practice Guideline (ESCP), developed by the EXPeRT network in collaboration with adult NEN experts, provides (adult) evidence ...
Michaela Kuhlen, Calogero Virgone, Antje Redlich, Michael Abele, Ricardo Lopez‐Almaraz, Tal Ben‐Ami, Ewa Bien, Gianni Bisogno, Maja Mazic Cesen, Andrea Ferrari, Malgorzata A. Krawczyk, Yves Reguerre, Dominik T. Schneider, Ines B. Brecht, Charlotte Rigaud, Bilgehan Yalcin, Rainer Claus, Christian Vokuhl, Constantin Lapa, Jörg Fuchs, Segolene Hescot, Thomas Walter, Julien Hadoux, Daniel Orbach   +23 more
wiley   +1 more source

Health‐Related Quality of Life and Symptom Severity Among Patients With PIK3CA‐Related Overgrowth Spectrum: A Mixed‐Methods Study to Understand Real‐World Experience With Alpelisib Treatment

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background PIK3CA‐related overgrowth spectrum (PROS) includes several rare overgrowth disorders resulting from somatic gain‐of‐function mutations in PIK3CA. Despite treatment advances, including the recent approval of alpelisib for PROS in the United States, literature detailing the patient experience with PROS is limited.
Vamsi Bollu, Kaitlin LaGasse, Cory D. Saucier, Kimberly Raymond, Miranda Lauher‐Charest, Lauren Crowder, Beilei Cai, Mary Lisha Paul, Denise Adams   +8 more
wiley   +1 more source

Hospitalization Through Families’ Eyes: Comparing Inpatient Care Quality for Children With Sickle Cell Disease and Cystic Fibrosis in Canada

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Sickle cell disease (SCD) is a chronic, inherited hemoglobinopathy that requires frequent hospitalization for disease‐related complications. Canadian data on inpatient care is limited. This study compared caregiver‐reported hospital experiences of children with SCD to those with cystic fibrosis (CF), a chronic, autosomal recessive ...
Hailey M. Zwicker, Kyle Kemp, Perri Tutelman, Sharon H. J. Hou, Paul Fairie, Maria Santana, Gregory M. T. Guilcher, Taryn Fay‐McClymont, Glenda Bendiak, Wendy Pelletier, Nicola Wright, Fiona Schulte   +11 more
wiley   +1 more source

Management of autism in children and young people : a good clinical practice guideline - Executive summary

, 2014
9 p.ill.,FOREWORD 1 -- TABLE OF CONTENTS 2 -- EXECUTIVE SUMMARY 3 -- 1. INTRODUCTION 3 -- 2. OBJECTIVES AND SCOPE OF THIS GUIDELINE 4 -- 2.1. SCOPE 4 -- 2.2. RESEARCH QUESTIONS 4 -- 3. METHODS 4 -- 3.1.
Veereman, Geneviève
core   +1 more source